Project Grant R43MH109212

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $343,203 to Cyion Technologies LLC to develop a novel in vitro electrophysiology system for high-throughput measurement of intracellular action potential (IAP) in human-derived cardiomyocytes. The system leverages a 3D nanoelectrode array (NEA) technology to enable scalable recordings of IAP signals from many individual cardiomyocytes. This...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $170,678 Project Grant (R21EB036615) to the University of Cincinnati for the project "Aptamer Tagging with Redox Quenchers: A Critical Breakthrough in the Sensitivity of Continuous Electrochemical Protein Monitoring". The objective is to develop and test the first continuous in-vivo sensors capable of monitoring large analytes (e.g., insulin, cardiac markers, inflammatory proteins) with unprecedented...

This Project Grant award for $447,304.00 was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The goal of the project is to develop a compact, integrated circuit-based single-molecule assay (SIMOA) system that can electronically detect and count individual protein biomarkers related to neurodegenerative diseases, such as α-synuclein,...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $349,566 supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The grant was awarded on April 2, 2025 and is set to be completed by March 31, 2026. The SFNOA...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $671,072 to the University of Washington to develop a novel "picoliter thin-layer chromatography (PTLC)" device. This miniaturized lab-on-chip technology aims to improve the sensitivity and throughput of thin-layer chromatography, enabling single-cell analysis of lipid-modifying enzyme activity in cancer patient samples. The project will...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is supporting the development and commercialization of the Acoustodrop platform - an acoustic-based, contactless liquid-handling technology. The $1,965,880 award to Ascent Bio-Nano Technologies, Inc. will be used to improve the performance of the Acoustodrop chips, develop self-contained prototypes, and validate the technology's...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will enable the development of a high-throughput microfluidic platform to systematically study enzyme function and catalytic mechanisms. Specifically, the $148,568 award will fund the use of noncanonical amino acids to precisely perturb the active site of the enzyme alanine racemase, a model system for understanding the catalytic mechanisms of...