Project Grant R43CA236167

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $383,482 to Electronic Biosciences, Inc. to develop SPINSEQ, an innovative RNA sequencing platform. The goal is to create a highly precise and accurate technology that can detect critical RNA modifications, overcoming limitations of existing RNA sequencing methods. During this Phase I project, the company will focus on developing and optimizing the...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....

The National Institute of General Medical Sciences (NIGMS) awarded Attogene Corporation, a biotechnology company based in Austin, Texas, a $229,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a rapid, portable, and sensitive test for detecting ribonucleases (RNases). The grant supports the company's efforts to create a novel lateral flow assay prototype that can quickly identify RNase contamination, which is critical for ensuring quality...

This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859, the Biomedical Research and Research Training program, provides $350,000 in funding to Electronic Biosciences, Inc. to develop a novel technology for high-accuracy, simultaneous sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A). The project aims to merge innovative bisulfite adduct sequencing methodology with Electronic Biosciences' enzyme-free, multi-pass...

This Project Grant award of $383,748 from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports the development of a CRISPR-based depletion technology by Jumpcode Genomics Inc. to resolve pseudogene contamination in next-generation sequencing (NGS)-based genetic testing, with a focus on improving newborn screening (NBS) clinical tests. The key objectives of this award are to computationally design CRISPR guide RNAs, optimize depletion...

This Project Grant from the National Science Foundation's $287,403 Engineering program will fund research at Southern Methodist University from March 2021 through February 2024. The University will develop ultrasensitive nucleic acid sensing tools based on Cas assays and solid-state nanopores. The Engineering program aims to improve quality of life and economic strength through innovative engineering research and education. This award supports those goals by advancing technologies for rapid,...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a novel high-throughput screening (HTS) assay platform that can directly monitor drug-induced changes in RNA levels of dengue and influenza viruses. The $300,000 award to Lucerna Inc., a minority-owned small disadvantaged business, will fund the creation of this HTS-compatible cell-based reporter system to...

This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...