Cooperative Agreement R41DE026083

This Project Grant awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program focuses on advancing 3D printing techniques for zirconia dental restorations. The $550,000 grant, with a period of performance from February 1, 2025 to January 31, 2027, is awarded to the University of Texas at Dallas (UTD). The project aims to enhance the adhesion properties of 3D printed zirconia, a durable and biocompatible material, for use in dental...

This $27,030 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to understand how biofilm formation and adhesion is affected by 3D-printed titanium surfaces used in dental implants. The key objectives are to develop experimental tools for measuring structural, deformation, and diffusive properties of single and multi-species oral biofilms on 3D-printed titanium...

This SBIR Phase I Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $275,000 to T33 Dental, Inc. to validate a novel device and approach for enhancing the delivery of pharmaceuticals and cosmetics into whole human teeth. The project aims to develop a system to improve the permeability of drugs and cosmetic treatments for addressing tooth decay and enabling more effective dental procedures. Key focus areas...

This Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) provides $249,999 to The Trustees of the University of Pennsylvania for the development of a smart dental implant system. The award will support research and educational activities from September 2022 through August 2025. Specifically, the grantee will build a strategy to prevent peri-implant disease through enhancing soft tissue immunity near dental implants. They will develop an ambulatory care platform...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $270,594 Project Grant to Greenmark Biomedical Inc. on Sep 1, 2025. The grant supports the development of nano-fluorapatite particles to directly fill subsurface enamel pores, with the goal of halting the progression of non-cavitated carious lesions without requiring multiple remineralization treatments. Preliminary data demonstrates the ability of...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded Rytek Medical Inc. a $220,000 Project Grant on August 1, 2025. The grant supports research to evaluate CT/X-ray imaging-correlated impedance-based metrics for predicting surgical osseointegration and injury prevention in dental implant procedures. The project aims to develop innovative diagnostic technologies, such as an impedance-based...

This $349,996 federal Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program aims to develop a new dental technology to improve oral health through microbial transplantation. The project will test the use of beneficial oral microbes from healthy donor dental plaque to treat conditions like dental decay and gum disease in recipients. The effort will employ a 3D printed system to grow and propagate the transplanted microbes, with the...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...

The $296,171 Project Grant awarded on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to design and evaluate an impedance-based bone assessment technology for characterizing trabecular bone microarchitecture. This technology is intended to address the limitations of current imaging techniques, like cone beam CT, in accurately quantifying bone quality, particularly in the trabecular...