Not listed SYNVITROBIO, INC. PROJECT TITLE: ''HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS'' WITH THIS ACTION, ARPA-E IS RENEWING A NON-COMPETITIVE AWARD TO SYNVITROBIO, INC. UNDER THE AWARD NUMBER DE-AR0001457 TITLED "HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS." THIS NON-COMPETITIVE AWARD ALLOWS ARPA-E AND SYNVITROBIO, INC. (DBA TIERRA BIOSCIENCES) TO WORK TOGETHER TO BRING THEIR HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS PROJECT TO THE NEXT LEVEL OF MATURITY, WITH THE GOAL OF GENERATING MORE THAN 500 UNIQUE PROTEINS PER WEEK AT SCALES APPROPRIATE FOR HIGH THROUGHPUT SCREENING AT A COMPETITIVE PRICE POINT. THESE QUANTITIES ARE SUFFICIENT FOR DOWNSTREAM SCREENING OPERATIONS CRITICAL TO THE ESTABLISHMENT OF A CELL-FREE BIOMANUFACTURING INDUSTRY THAT CAN DISRUPT TRADITIONAL FERMENTATIVE PRODUCTION OF BIOFUELS AND RELATED PRODUCTS AND IMPROVE THEIR CARBON AND ENERGY EFFICIENCY. THE OBJECTIVES OF THIS FINANCIAL ASSISTANCE WILL ASSIST ARPA-E IN MEETING THE PROVISIONS IN 42 U.S.C. 16538 (AMERICA COMPETES ACT), INCLUDING ITS TWIN GOALS OF (A) ENHANCING THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES; AND (B) ENSURING THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES. AMENDMENT 0001 PROVIDED AUTHORIZATION FOR THE PRIME RECIPIENT TO PROCEED WITH WORK IN BUDGET PERIOD 2. AMENDMENT 0002 REVISED THE ARPA-E PROGRAM DIRECTOR TO KIRK LIU AND EXTENDED THE PERIOD OF PERFORMANCE UNTIL 05/07/2023. AMENDMENT 0003 EXTENDED THE PERIOD OF PERFORMANCE UNTIL 11/07/2023. AMENDMENT 0004 EXTENDED THE PERIOD OF PERFORMANCE UNTIL 05/07/2024 AND REVISED THE ARPA-E PROGRAM DIRECTOR TO STEVEN SINGER. AMENDMENT 0005 PROVIDED ADDITIONAL FUNDS ($1,750,000.00 FEDERAL AND $350,084.00 NON-FEDERAL), EXTENDED THE PERIOD OF PERFORMANCE UNTIL 11/07/2025, AND REVISED ATTACHMENTS 1-5. AMENDMENT 0006: NO COST EXTENSION $0 6/17/26 Not listed SYNVITROBIO, INC. PROJECT TITLE: ''HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS'' WITH THIS ACTION, ARPA-E IS RENEWING A NON-COMPETITIVE AWARD TO SYNVITROBIO, INC. UNDER THE AWARD NUMBER DE-AR0001457 TITLED "HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS." THIS NON-COMPETITIVE AWARD ALLOWS ARPA-E AND SYNVITROBIO, INC. (DBA TIERRA BIOSCIENCES) TO WORK TOGETHER TO BRING THEIR HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS PROJECT TO THE NEXT LEVEL OF MATURITY, WITH THE GOAL OF GENERATING MORE THAN 500 UNIQUE PROTEINS PER WEEK AT SCALES APPROPRIATE FOR HIGH THROUGHPUT SCREENING AT A COMPETITIVE PRICE POINT. THESE QUANTITIES ARE SUFFICIENT FOR DOWNSTREAM SCREENING OPERATIONS CRITICAL TO THE ESTABLISHMENT OF A CELL-FREE BIOMANUFACTURING INDUSTRY THAT CAN DISRUPT TRADITIONAL FERMENTATIVE PRODUCTION OF BIOFUELS AND RELATED PRODUCTS AND IMPROVE THEIR CARBON AND ENERGY EFFICIENCY. THE OBJECTIVES OF THIS FINANCIAL ASSISTANCE WILL ASSIST ARPA-E IN MEETING THE PROVISIONS IN 42 U.S.C. 16538 (AMERICA COMPETES ACT), INCLUDING ITS TWIN GOALS OF (A) ENHANCING THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES; AND (B) ENSURING THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES. AMENDMENT 0001 PROVIDED AUTHORIZATION FOR THE PRIME RECIPIENT TO PROCEED WITH WORK IN BUDGET PERIOD 2. AMENDMENT 0002 REVISED THE ARPA-E PROGRAM DIRECTOR TO KIRK LIU AND EXTENDED THE PERIOD OF PERFORMANCE UNTIL 05/07/2023. AMENDMENT 0003 EXTENDED THE PERIOD OF PERFORMANCE UNTIL 11/07/2023. AMENDMENT 0004 EXTENDED THE PERIOD OF PERFORMANCE UNTIL 05/07/2024 AND REVISED THE ARPA-E PROGRAM DIRECTOR TO STEVEN SINGER. AMENDMENT 0005 PROVIDED ADDITIONAL FUNDS ($1,750,000.00 FEDERAL AND $350,084.00 NON-FEDERAL), EXTENDED THE PERIOD OF PERFORMANCE UNTIL 11/07/2025, AND REVISED ATTACHMENTS 1-5. AMENDMENT 0006: NO COST EXTENSION $0 1/16/26 Not listed SYNVITROBIO, INC., AMENDMENT 0005: THE PURPOSE OF THIS AMENDMENT IS TO PROVIDE ADDITIONAL FUNDS, EXTEND THE POP, AND REVISE ATTACHMENTS 1, 3, 4 AND 5. PROJECT TITLE: ''HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS'' WITH THIS ACTION, ARPA-E IS RENEWING A NON-COMPETITIVE AWARD TO SYNVITROBIO, INC. UNDER THE AWARD NUMBER DE-AR0001457 TITLED "HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS." THIS NON-COMPETITIVE AWARD ALLOWS ARPA-E AND SYNVITROBIO, INC. (DBA TIERRA BIOSCIENCES) TO WORK TOGETHER TO BRING THEIR HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS PROJECT TO THE NEXT LEVEL OF MATURITY, WITH THE GOAL OF GENERATING MORE THAN 500 UNIQUE PROTEINS PER WEEK AT SCALES APPROPRIATE FOR HIGH THROUGHPUT SCREENING AT A COMPETITIVE PRICE POINT. THESE QUANTITIES ARE SUFFICIENT FOR DOWNSTREAM SCREENING OPERATIONS CRITICAL TO THE ESTABLISHMENT OF A CELL-FREE BIOMANUFACTURING INDUSTRY THAT CAN DISRUPT TRADITIONAL FERMENTATIVE PRODUCTION OF BIOFUELS AND RELATED PRODUCTS AND IMPROVE THEIR CARBON AND ENERGY EFFICIENCY. THE OBJECTIVES OF THIS FINANCIAL ASSISTANCE WILL ASSIST ARPA-E IN MEETING THE PROVISIONS IN 42 U.S.C. 16538 (AMERICA COMPETES ACT), INCLUDING ITS TWIN GOALS OF (A) ENHANCING THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES; AND (B) ENSURING THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES. $1.8m 9/30/24 Not listed NON-COMPETITIVE AWARD TO SYNVITROBIO, INC. PROJECT TITLE: ''HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS'' THE PURPOSE OF THIS AMENDMENT NUMBER 0004 IS TO PROVIDE A NCE UNTIL 5/7/24 AND REVISE THE PD $0 11/1/23 Not listed NON-COMPETITIVE AWARD TO SYNVITROBIO, INC. PROJECT TITLE: ''HIGH-THROUGHPUT CELL-FREE PROTEIN SYNTHESIS FOR RAPID BIOENERGY PATHWAY IMPROVEMENTS'' THE PURPOSE OF THIS AMENDMENT NUMBER 0003 IS TO PROVIDE A NCE UNTIL 11/7/23 $0 5/31/23