Cooperative Agreement 2533727
- The National Science Foundation (NSF) awarded a $979,298 Cooperative Agreement under its Technology, Innovation, and Partnerships (CFDA 47.084) program to Asante Bio LLC, a small disadvantaged business, to develop a Multi-Axial Filament Winding Process (3DMF) for biomanufacturing high-performance orthobiologic implants for rotator cuff repair. This two-year project aims to optimize the manufacturing, surgical delivery, biomechanical performance, and biocompatibility of the 3DMF implants, which...
- The National Science Foundation awarded Modular Matter, Inc. $305,000 on October 1, 2026, under NSF Technology, Innovation, and Partnerships (CFDA 47.084) to develop a universally adjustable, modular prosthesis socket system. The recipient will design and prototype expandable, modular components fabricated using selective laser sintering that can be assembled, configured, and reconfigured to accommodate individual limb shapes and volume fluctuations. The system targets both upper and lower...
- Biosapien Inc. received a $256,000 Project Grant award from the National Science Foundation on May 1, 2021 to develop a novel 3D printed biodegradable mesh delivering active pharmaceutical ingredients in a sustained and localized manner under the Small Business Innovation Research Phase I program. The SBIR Phase I grant supports the proof-of-concept stage of developing Biosapien's technology, with the work expected to be completed by June 30, 2022. The NSF Technology, Innovation, and...
- The National Science Foundation awarded Mechano Therapeutics LLC a $1.240 million cooperative agreement on August 1, 2026, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a force-stimulated delivery platform for controlled therapeutic release in joint environments. The project focuses on mechanically activated microcapsules that harness natural joint forces to deliver therapeutics with improved bioavailability and reduced systemic toxicity. Work includes...
- This National Science Foundation (NSF) Cooperative Agreement award under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $1,000,000 in funding to Amphix Bio Inc. to develop scalable manufacturing methods for a novel supramolecular polymer-based spinal implant. The project aims to enable safer, simpler, and lower-cost spinal fusion surgery by advancing this regenerative medicine technology. The key deliverables include scaling up the production of the...
- The National Science Foundation awarded Stemora Inc. $305,000 in project grant funding on July 1, 2026, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a therapeutic strategy for in vivo hyaline cartilage regeneration through biochemical modulation of resident skeletal stem cells. Stemora will optimize a combination of clinically established microfracture surgery with a controlled-release formulation containing biochemical signals to direct skeletal stem...
- This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $304,906 to Seabird Lifesciences LLC for the development of a novel bioprinting approach to create vascular grafts. The project aims to produce a next-generation vascular graft that improves outcomes for patients undergoing vascular surgeries by enhancing tissue integration, improving long-term performance, and reducing the need for repeat...
- This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
- This $256,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of additive manufacturing techniques for soft tissue repair. Asante Bio LLC will receive funding to design and engineer a novel 3D microfiber printer capable of assembling synthetic biopolymer filaments into fibrous, flexible implants that promote soft tissue healing. Through this six-month award ending November 2022, Asante Bio will optimize...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award to Reselute, Inc. provides $998,921 to develop a novel implantable orthopedic medical device and procedure to reduce recovery duration and infection risks associated with severe traumatic fractures of the long bones. The project aims to advance a 3D-printed, antibiotic-releasing intramedullary nail to improve upon current standard-of-care implants that are prone to...
The National Science Foundation awarded Genassist Inc. a $1.248 million cooperative agreement on August 1, 2026, to develop and validate a clinic-ready acellular biomimetic scaffold (MyoSponge) for treating volumetric muscle loss. This SBIR Phase II project, funded under NSF Technology, Innovation, and Partnerships (CFDA 47.084), will optimize manufacturing processes to ensure consistency and scalability, perform comprehensive preclinical safety and efficacy studies aligned with regulatory guidance, and refine the material's properties to maximize functional recovery. The engineered biomimetic scaffold previously demonstrated the ability to increase muscle function and improve muscle architecture in earlier work. Genassist will deliver a regenerative scaffold intended to serve as the foundation for future innovations in musculoskeletal and soft tissue repair, with potential to significantly improve health outcomes and reduce long-term rehabilitation costs for patients with volumetric muscle loss. Performance occurs in Cape Girardeau, Missouri, with a period of performance extending through July 31, 2028. No sub-recipients are planned for this award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/24/26 |