Cooperative Agreement 2452693
- This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...
- The National Science Foundation (NSF) awarded Pearl Bio, Inc., a biotechnology company, a $274,462 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The grant funded the development of a next-generation biomanufacturing platform to engineer new microbial organisms and cellular machinery. This platform enables the incorporation of diverse, non-native components into proteins, creating a new class of biological materials for therapeutic development,...
- This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program is focused on developing a modular, standardized platform for cell-free bioprocessing. The $3,091,750 project, awarded to Georgia Tech Research Corporation, aims to create eight reusable modules covering essential cell-free functions like energy generation and protein expression. These "ready-to-use" modules will enable faster and more efficient...
- This Cooperative Agreement award of $2,375,361 from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop user-friendly computational tools that allow researchers to design improved protein "transporters" to enhance the efficiency of biomanufacturing processes. The project will leverage advancements in artificial intelligence and machine learning to identify and optimize transporter proteins that control the...
- This Cooperative Agreement award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) provides $2,996,108.00 to the University of California, Irvine to develop more efficient cell-free biomanufacturing processes. The project aims to upgrade cell-free cascades by using membraneless compartmentalization techniques to improve the organization and efficiency of chemical reactions without the constraints of living cells. This approach leverages...
- The National Science Foundation (NSF) awarded a Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Femtofluidics Incorporated for $294,932 on January 1, 2025. The purpose of this SBIR Phase I award is to develop hardware that enables the rapid and inexpensive synthesis of DNA-encoded libraries (DELs). This technology aims to accelerate drug discovery by expediting the identification of drug candidates for challenging diseases and generating data to...
- This Project Grant award of $275,000.00 from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development of a novel platform to accelerate strain development for precision fermentation. The goal is to create an alternative means of food protein production to reduce the environmental impact of traditional livestock farming. The platform leverages machine learning and experimental biology to enable high-yield production of a...
- The National Science Foundation (NSF) awarded a $1,180,313 Cooperative Agreement to Bluestem Biosciences Inc., a for-profit company based in Omaha, Nebraska, under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The funding will support a 24-month project focused on developing an optimized yeast strain capable of efficiently producing the chemical intermediate 3-hydroxypropionic acid (3-HP) under anaerobic conditions. The broader impact of this project is to establish a...
- This Cooperative Agreement award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $2,686,207 to the University of California, Santa Barbara to transform abundant plant materials into high-value products like fuels, oils, and surfactants. The project aims to enhance the activity of key enzymes needed to convert waste biomass through AI-guided protein design and directed evolution. Key technical approaches include using machine learning...
- This $2,233,515 Cooperative Agreement awarded by the National Science Foundation (CFDA 47.084 - Technology, Innovation, and Partnerships) to Arzeda Corp. aims to transform the production of acrylates, which are key components in paints, plexiglass, and super-absorbent materials. The project will leverage artificial intelligence and advanced protein engineering to develop a scalable, cost-effective, and cell-free biocatalytic process for producing methylene butyrolactone (MBL), a bio-based...
The National Science Foundation (NSF) awarded a $2,808,001 Cooperative Agreement under the Technology, Innovation, and Partnerships (CFDA 47.084) program to Caravel Bio, Inc. in Portland, OR. The project aims to develop an advanced platform combining computational protein design, shelf-stable cell-free systems, and genetic code expansion to enable the cost-effective production of useful proteins and biomolecules without relying on living cells. Key focus areas include reducing DNA synthesis costs, creating affordable livestock/pet vaccines, and designing a powerful industrial enzyme. By integrating these innovative technologies, the project seeks to establish a universal workflow for protein engineering and application, while increasing throughput and resilience of cell-free biosynthesis systems. The goal is to spark biotechnology innovation and reinforce U.S. leadership in this critical domain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 8/26/25 |