This $252,906 National Science Foundation project grant supports the development of scalable manufacturing methods for peptide amphiphile molecules by Amphix Bio Inc. The goal is to advance a safer and more affordable alternative to recombinant proteins currently used in spinal fusion surgeries. Over 500,000 such surgeries are performed annually in the U.S. to treat back and neck pain. While peptide amphiphiles show promise for reducing biological dose needs and offering consistent outcomes,...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award to Reselute, Inc. provides $998,921 to develop a novel implantable orthopedic medical device and procedure to reduce recovery duration and infection risks associated with severe traumatic fractures of the long bones. The project aims to advance a 3D-printed, antibiotic-releasing intramedullary nail to improve upon current standard-of-care implants that are prone to...
This Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Orthomechanica, Inc., a small minority-owned business located in Corvallis, OR. The funding supports the design, engineering, and preclinical validation of a novel implantable medical device that aims to improve functional outcomes for over 100,000 patients annually undergoing reconstructive surgery. The device integrates a...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $305,000 to Novaurum Biosciences Incorporated to develop a novel mammalian cell-based nano-biological coating for implantable medical devices. The project aims to address the critical issue of implant-related infections, which cost the U.S. healthcare system over $8.6 billion annually. The proposed nano-biological coating is designed to inhibit biofilm formation and...
The National Science Foundation (NSF) awarded a $1,000,000 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Impressio Inc., a for-profit manufacturer headquartered in Thornton, Colorado. The award supports the development, verification, validation, and commercialization of a liquid-crystal elastomer (LCE)-based cartilage replacement device to treat hallux rigidus, a joint disorder affecting the base of the big toe. The project aims to...
The National Science Foundation (NSF) awarded a $1,016,000 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Nostopharma LLC, a woman-owned small disadvantaged business, to develop an innovative sustained-release, biodegradable drug delivery system for treating post-traumatic injuries. The project aims to create a localized and targeted drug delivery platform using anti-inflammatory nanoparticles and Hedgehog pathway antagonists, with the...
The National Science Foundation (NSF) awarded a $979,298 Cooperative Agreement under its Technology, Innovation, and Partnerships (CFDA 47.084) program to Asante Bio LLC, a small disadvantaged business, to develop a Multi-Axial Filament Winding Process (3DMF) for biomanufacturing high-performance orthobiologic implants for rotator cuff repair. This two-year project aims to optimize the manufacturing, surgical delivery, biomechanical performance, and biocompatibility of the 3DMF implants, which...
This Cooperative Agreement award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) provides $1,000,000 in funding to Winter Innovations, Inc. to develop a novel suturing device for orthopedic ligament and tendon surgical procedures. The innovation utilizes a two-part needle technology to improve surgical consistency, reduce procedure times by one-third, and decrease revision rates by nearly two-thirds compared to current...
This NSF Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award to President and Fellows of Harvard College (Harvard University) provides $550,000 in funding from August 1, 2024 to July 31, 2026 to develop a minimally-invasive, catheter-based additive manufacturing platform capable of creating customized medical implants directly inside the human body. The project aims to transform the field of medical implants by enabling on-demand fabrication of personalized 3D-printed...
This Cooperative Agreement award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $1,250,000 in funding to Biodevek Inc., a small business located in Boston, MA, to advance the development of a novel sprayable hydrogel sealant for gastrointestinal wound protection. The project aims to create the first minimally invasive, bio-adhesive hydrogel solution to manage gastrointestinal lesions and bleeding, with the...