Cooperative Agreement 2233656
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Connecticut $8,044,252 on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop implantable, degradable drug delivery devices for non-opioid post-surgical pain management. The three-year project, scheduled for completion by August 31, 2028, addresses a critical clinical need, as approximately one in nine Americans undergoes...
- This National Science Foundation (NSF) Small Business Technology Transfer (STTR) Phase I project aims to develop a novel, minimally invasive, bioabsorbable, steroid-eluting suture and surgical implant procedure to improve outcomes for 6 million patients suffering from rhinitis under the care of otolaryngologists. The $255,045 award, granted on September 15, 2023 under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, will fund the formulation of dissolvable polymers,...
- Federal Grant Award Summary Award: SBIR Phase I: Percutaneous Spinal Cord Stimulation Paddle Lead Using Shape Memory Polymer Funding Agency: National Science Foundation (NSF), Technology, Innovation, and Partnerships Program (CFDA 47.084) Awardee: Backstop Neural, Inc. (Dallas, TX) Award Amount: $304,259 | Award Date: October 1, 2025 | Performance Period: October 1, 2025 – June 30, 2026 Backstop Neural, Inc. will develop a minimally invasive spinal cord stimulation (SCS) lead utilizing shape...
- This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...
- Nostopharma LLC was awarded a $256,000 Small Business Technology Transfer Phase I Project Grant from the National Science Foundation to develop a sustained-release, biodegradable nanoparticle drug delivery system for treatment of soft tissue trauma complications. Funded under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the 12-month project beginning March 1, 2022 aims to demonstrate in vitro and in vivo feasibility of modulating the ectopic bone microenvironment...
- This $252,906 National Science Foundation project grant supports the development of scalable manufacturing methods for peptide amphiphile molecules by Amphix Bio Inc. The goal is to advance a safer and more affordable alternative to recombinant proteins currently used in spinal fusion surgeries. Over 500,000 such surgeries are performed annually in the U.S. to treat back and neck pain. While peptide amphiphiles show promise for reducing biological dose needs and offering consistent outcomes,...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $2,505,537 to The Leland Stanford Junior University to develop a focused ultrasound (FUS) device for noninvasive, peripheral nerve blockade to manage acute pain. The goal is to provide an alternative to opioids and current peripheral nerve block techniques, which have significant limitations in acute pain management. The...
- Federal Project Grant Award Summary Aventusoft LLC received a $699,710 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with an award date of September 5, 2025 and completion date of February 28, 2027. Under this Small Business Innovation Research (SBIR) Phase I project, Aventusoft is developing PainVitals, an artificial intelligence-powered, non-invasive wearable biosensor system...
- Federal Grant Award Summary Tactorum Inc. received a $305,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships program (CFDA 47.084) on January 15, 2026, for a twelve-month performance period concluding December 31, 2026. The company is developing an automated pain behavior testing system designed to enhance preclinical pain research in rodents. The system addresses significant limitations in current...
- This SBIR Phase I Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $275,000 to T33 Dental, Inc. to validate a novel device and approach for enhancing the delivery of pharmaceuticals and cosmetics into whole human teeth. The project aims to develop a system to improve the permeability of drugs and cosmetic treatments for addressing tooth decay and enabling more effective dental procedures. Key focus areas...
SBIR PHASE II: NOVEL, INJECTABLE, LONG-ACTING, LOCAL ANESTHETIC FOR POSTOPERATIVE PAIN MANAGEMENT -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT IS A NOVEL THERAPEUTIC FOR SURGICAL PAIN THAT CAN ELIMINATE THE NEED FOR OPIOIDS AFTER SURGERY. THIS PROJECT WILL YIELD A NOVEL, LONG-ACTING LOCAL ANESTHETIC DRUG PRODUCT THAT CAN PROVIDE SUBSTANTIAL VALUE TO CUSTOMERS AS AN AFFORDABLE, SAFE, AND EFFECTIVE, NON-OPIOID, ACUTE PAIN MANAGEMENT SOLUTION. THE TECHNOLOGY CAN PROVIDE SIGNIFICANT VALUE TO HOSPITAL SYSTEMS, PHYSICIANS, AND PATIENTS ALIKE BY REDUCING HEALTHCARE COSTS ASSOCIATED WITH OPIOID-RELATED ADVERSE EVENTS AND PREVENTING OPIOID ADDICTION BY ELIMINATING THEIR USE AFTER SURGERY. IN 2021, THERE WAS A HISTORIC RISE IN OPIOID OVERDOSE DEATHS TO OVER 80,000 INDIVIDUALS. OPIOID USE DISORDER-RELATED MEDICAID SPENDING HAS MORE THAN TRIPLED IN THE LAST 15 YEARS AND THE OPIOID CRISIS HAS BEEN ESTIMATED TO COST $72.4 BILLION DURING THAT TIME PERIOD. PREVENTING OPIOID ADDICTION BY REDUCING EXPOSURE OF OPIOIDS TO SURGICAL PATIENTS CAN HAVE A SIGNIFICANT IMPACT ON REDUCING FINANCIAL COSTS TO SOCIETY AS A WHOLE. IN 2017, THERE WERE AN ESTIMATED 48 MILLION MAJOR SURGICAL PROCEDURES REQUIRING POSTOPERATIVE PAIN MANAGEMENT IN THE UNITED STATES, REPRESENTING A $17 BILLION TOTAL ADDRESSABLE US MARKET. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT SEEKS TO PERFORM FOOD AND DRUG ADMINISTRATION (FDA) REQUIRED MANUFACTURING CHARACTERIZATION AND ANIMAL STUDIES TO DEMONSTRATE THE NOVEL, INJECTABLE, LONG-ACTING LOCAL ANESTHETIC TECHNOLOGY IS SAFE FOR INITIAL HUMAN USE. THE SOLUTION INVOLVES A NOVEL OLEOGEL-BASED INJECTABLE DRUG DELIVERY SYSTEM THAT CAN PROVIDE LOCAL SUSTAINED DELIVERY OF LIPOPHILIC SMALL MOLECULE DRUGS. IN PHASE I, THE TEAM OPTIMIZED THE TECHNOLOGY FOR RHEOLOGICAL PROPERTIES, DRUG RELEASE KINETICS, AND STABILITY TO CREATE AN INJECTABLE GEL THAT PROVIDES 96 HOURS OF SUSTAINED BUPIVACAINE DELIVERY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/29/25 | ||
| Not listed | $500.0k | 9/10/24 | ||
| Not listed | $1.0m | 3/23/23 |