This is a $56,000.00 firm-fixed-price purchase order awarded by the National Institute of Environmental Health Sciences (NIEHS), part of the U.S. Department of Health and Human Services (HHS), to Schrodinger LLC for a PyMOL and AXPyMOL software site license renewal. PyMOL and AXPyMOL are molecular visualization and analysis software packages used to support drug review, research efforts, and computational capabilities across various government agencies. Schrodinger LLC, a subsidiary of Schrodinger, Inc., is a leading provider of advanced chemical simulation software for pharmaceutical, biotechnology, and materials research applications. This award does not have a set-aside designation, reflecting Schrodinger's specialized expertise in providing scientific software solutions to federal customers, including civilian agencies within HHS like the Food and Drug Administration (FDA), National Institutes of Health (NIH), and National Cancer Institute (NCI), as well as defense agencies.