Purchase Order 75N95021P00580
- Not listed
- This is a cost-plus-fixed-fee delivery order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), to the Lovelace Biomedical Research Institute, a not-for-profit preclinical contract research organization. The $520,896.73 contract is for the evaluation of drug efficacy in a rat model of neuropathic pain. Lovelace Biomedical Research Institute has experience conducting animal studies, including for federal...
- This is a $249,167.58 firm fixed price purchase order awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency under the National Institutes of Health (NIH), to Gempharmatech LLC, a foreign-owned for-profit biotech company. The contract is for the development of humanized mouse models for nicotinamide N-methyltransferase (NNMT) and sulfotransferase (SULT1A1) using CRISPR knock-in technology. The contractor will conduct biochemical testing of inhibitors and...
- This is a firm-fixed price purchase order awarded by the Department of Health and Human Services' National Institutes of Health (NIH) National Institute on Drug Abuse to PGI Holding Corporation, a for-profit subchapter S corporation. The contract, valued at $139,400.00, is for the engraftment of human induced pluripotent stem cell (iPSC) derived astrocytes into the forebrain of adult and neonatal wild type mice. The contract was awarded on a non-competitive basis under simplified acquisition...
- This is a federal contract award from the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse to Pharmaron, Inc., a global contract research organization. The $281,751.22 purchase order contract is for a firm fixed price and does not have a set-aside designation. Under this contract, Pharmaron is conducting a variety of drug development activities to support the work of the NIH's National Center for Advancing Translational Sciences...
- This is a $3,893,053.00 cost-plus-fixed-fee delivery order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency, to the Lovelace Biomedical Research Institute, a not-for-profit organization. The contract is for the characterization of a non-addictive small molecule therapeutic for the management of non-cancer pain, with a period of performance from September 18, 2020 to September 17, 2022, and an ultimate completion date of April 28, 2025....
- This is a cost-plus-fixed-fee delivery order awarded by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences (NCATS) to Sri International, a non-profit research institute. The $464,908.00 contract is for non-clinical safety assessment of the drug candidate NES100 to support its development for an analgesia (pain relief) indication. The period of performance is from September 17, 2020 to March 16, 2021. This delivery order...
- This is a $20,973.00 firm fixed price purchase order awarded by the National Institute on Drug Abuse (NIDA), a component of the U.S. Department of Health and Human Services, to PGI Holding Corporation, a for-profit subchapter S corporation. The contract is for binding assessment of 3H-PHNO and 3H-7-OH-DPAT in rat brain sections using autoradiography. PGI Holding Corporation provides scientific research and testing services to the federal government through contracts and grants, including...
- The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences (NCATS) awarded a $142,843.00 firm-fixed-price purchase order to Hesperos, Inc., a leading company in organ-on-a-chip technology, to provide scientific testing services. The contract is for the target validation and therapeutic evaluation of drug compound TRND00601748-01 in NGLY1 deficient cell-based models, including motoneurons and neuromuscular junction models. This...
- This is a $35,600 firm fixed price purchase order contract awarded by the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Pharmaron, Inc., a minority-owned for-profit organization, to conduct a mouse study evaluating NNMT inhibitors in high grade serous ovarian cancer. The work, which has a 12-month period of performance, involves formulating compounds, developing a mouse model, conducting efficacy studies, and analyzing samples. No set-aside...
- This is a $249,500 firm fixed-price purchase order awarded by the Department of Health and Human Services' National Institutes of Health National Institute on Drug Abuse to Chemogenics Biopharma, LLC, a small business. The contract is for synthesis and bioanalytical analysis support services related to the therapeutic areas of the microbiome, neurodegeneration, and addiction. The services will augment existing medicinal chemistry campaigns within the National Center for Advancing Translational...
This is a firm fixed-price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to PGI Holding Corporation, a for-profit subchapter S corporation, to evaluate the efficacy of a nanoparticle formulation containing the drug aprepitant in a rodent model of neuropathic pain. The contract, valued at $216,900.00, has a period of performance from September 20, 2021 to March 31, 2023. The work involves conducting a mouse spinal nerve spared (SNS) model of neuropathic pain, administering the nanoparticle and free drug formulations intrathecally, and evaluating mechanical allodynia using von Frey hairs. This contract is not designated as a small business set-aside.
Name | Description | Solicitation Number | FederalAgency | Type | PostedDate |
|---|---|---|---|---|---|
Evaluation of Drug Efficacy in a Rat Model of Neuropathic Pain | 75N95021Q00118 | Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse | Pre-Solicitation 1/2 | 4/6/21, 11:21 AM | |
Evaluation of Drug Efficacy in a Rodent Model of Neuropathic Pain | 75N95021Q00118 | Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse | Solicitation 2/2 | 7/27/21, 6:26 AM |
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| P00004 | Supplemental Agreement for work within scope | $0 | 12/1/22 | |
| P00003 | Supplemental Agreement for work within scope | $35.8k | 9/19/22 | |
| P00002 | Supplemental Agreement for work within scope | $0 | 1/10/22 | |
| P00001 | Supplemental Agreement for work within scope | $0 | 10/14/21 | |
| Not listed | Not listed | $181.1k | 9/17/21 |