Instrument & Laboratory Equipment - Fermenter / Bioreactor
This notice is a combined synopsis/solicitation Request for Quote NIAID-RFQ-19-1968057 for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The incorporated provisions and clauses are those in effect with the Federal Acquisition Circular 2019-03 dated July 12, 2019. The National Institute of Allergy and Infectious Diseases (NIAID), is requesting to procure one (1) Biostat B-DCU 2-fold MO 120v fermenter / bioreactor - #BIOSTATBDCUII, Installation in USA for 1-Biostat B-DCU MO (2016) - #S8762INSTP, Service Level Agreement: ESSENTIAL for year 2 and 3 incl.1st Year Maintenance (option period to be exercised 30 days before one (1) year warranty expires) - #S8762SLAE, BioPAT MFCS/win 3.1 - #BIOPATMFCS, and Installation in USA for 1 BioPAT MFCS/win 3.1 - #S8774INSTLP. This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and award will be made pursuant to the authority in FAR Part 13.501(a)(1). Only one award will be made as a result of this solicitation. This acquisition will be processed under Simplified Acquisition Procedures as a firm-fixed price type of contract, and is not a small business set-aside. The associated North American Industry Classification System (NAICS) Code is 333999, with the size standard of 500. Delivery to Gaithersburg, Maryland 20878 approximately 16 weeks after receipt and acceptance of award. The following apply to this acquisition: FAR Part 52.212-1 Instructions to Offerors - Commercial Items, FAR Part 52.212-4 Contract Terms and Conditions - Commercial Items, and FAR Part 52.212-5 - Contract Terms and Conditions Required to Implement Status or Executive Orders - Commercial Items (see attached), and by reference the Department of Health and Human Services Acquisition Regulation HHSAR 352.203-70 Anti-lobbying, HHSAR 352.222-70 Contractor Cooperation in Equal Employment Opportunity Investigations, and HHSAR 352.239-74 Electronic and Information Technology Accessibility. The Vaccine Production Program (VPP) has a requirement for a Sartorius Stedim Biostat B-DCU 2-fold MO 120v fermenter / bioreactor system consisting of 2 x 10L glass bioreactor vessels to expand microbial capabilities at VPP for making vaccine components for process development and generation of toxicology materials. The system is specially configured for cultivation of microorganisms such as bacteria, yeast, and fungi and can control two bioreactors at up to 10L working volume. This will allow the VPP to work with the Vaccine Clinical Materials Program (VCMP) that uses a similar system for their 100L good manufacturing practice (GMP) microbial production tank. In addition, there are Sartorius Stedim 6 x 1L microbial bioreactors currently in place at the VPP. This new requirement will allow for easier transfer and scalability of developed processes from the 1L to 10L all the way to 100L GMP production. The twin system allows two (2) 10L microbial reactors to be dually controlled by one control box, which saves lab bench real estate. The Biostat B system can cultivate bacteria, yeast, and fungi with control of temperature, pH, dissolved oxygen, and foam levels, which should serve future needs for generation of development and toxicology materials in microbes at VPP. The two (2) 10L bioreactor vessels are also autoclavable, which simplifies the need for utilities to sterilize the vessels in place. A turbidity sensor is also included, which can be used to automatically control feeding based on cell densities, and the MFCS/win software, process trends and alarms can also be tracked on the Biostat B twin system. There are no fermenter / bioreactors compatible with the existing Sartorius Stedim models; as such the formats down to great detail need to be the same. The flow rates, the tubing lengths, the pitch of the impellors, the heat transfer rates of the glass/steel, the reactor to be cleaned, the number of ports for both sampling and additions, and even the gas transfer/infusion methods all need to be accounted for and match current equipment existing and in operation of the VCMP. The fermenter / bioreactor must have the following ability to perform the following capabilities: run up to two 10L glass bioreactors independently using one control system, cultivate microorganisms such as bacteria, yeast, and fungi, cultivate anaerobic organisms by connecting N2 to the system, heat and cool bioreactors with actively growing cells up to 50C and down to 4C, track bioreactor process parameters and record process data and alarms continuously and write bioreactor processes using included software, display up to 8 process parameters on the control box screen at the same time in 1 h steps between 1 and 72 h, track and control pH and DO as well as to re-calibrate these probes over the course of the experiment, control foam and level and substrate additions in the bioreactor, to password protect for all controller outputs as well as available manual control for all controller outputs, mix air and O2 providing delivery tough a gas sparger to cells and maintain dissolve oxygen levels. Air and O2 flow rate ranges between 0.4-20 lpm tough mass flow controllers, control pH tough automated addition of acid and base, add substrate and totalize amounts added tough an addition pump, mix vessel contents tough a 200W motor, autoclave bioreactor vessels, and inclusion of pH, DO, foam and turbidity sensors. The following factors shall be used to evaluate offers: 1) capability to meet required specifications, 2) price, 3) warranty, and 4) delivery (approximately 16 weeks after receipt and acceptance of award). All responsible sources who can provide the equipment meeting the requirements of this solicitation may submit a response that could be considered by email (subject line to reference NIAID-RFQ-19-1968057) to Tonia Alexander at talexander@niaid.nih.gov, by 1:00 pm eastern standard time Monday, July 29, 2019. All information furnished must be in writing and must contain sufficient detail to allow NIAID to determine if it can meet the above specifications described herein. By submission of an offer, the Offeror confirms the requirement that a prospective Awardee shall be registered in the System for Award Management (www.sam.gov) database prior to award, during performance, and tough final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation. [Note: Lack of registration in SAM will make an Offeror ineligible for award.]. NIAID-RFQ-19-1968057 Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases
7/19/19, 5:56 PM