Purchase Order 36C26021P1091

This firm fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health within the Department of Health and Human Services, to Pharmaron, Inc. for $64,090. The contract is for Pharmaron to conduct a 14-day dose range-finding toxicity study in male and female rats to determine the maximally tolerated dose of an investigational molecule under development by NCATS. Specifically, Pharmaron will test the...

On September 18, 2024, the National Center for Advancing Translational Sciences (NCATS) awarded a $512,266 delivery order to IIT Research Institute (IITRI), a non-profit contract research organization and subsidiary of the Illinois Institute of Technology. The contract, which carries no set-aside designation, supports preclinical development of NCGC72, a first-in-class small molecule CD206 agonist candidate intended for treatment of immunologically cold solid organ cancers. Work will be...

The Environmental Protection Agency Office of Research and Development awarded a $238,223.06 firm fixed price delivery order to Integrated Laboratory Systems, LLC for mammalian oral exposure studies for two chemicals. Per the task order, Integrated Laboratory Systems will conduct two tolerability studies and two five-day repeat dose studies outlined in Attachment 1. The period of performance is through February 24, 2024 at the place of performance in Cincinnati, Ohio. Integrated Laboratory...

This contract award to Gempharmatech LLC, a foreign-owned biotechnology company in San Diego, California, is for a $58,936 fixed-price purchase order to evaluate the safety of the compound YC1 in mice with humanized SULT1A1 proteins versus standard mouse SULT1A1 proteins. The contract was awarded by the National Center for Advancing Translational Sciences (NCATS), which operates under the National Institutes of Health within the Department of Health and Human Services. The objective is to...

This is a cost-plus-fixed-fee delivery order contract awarded by the National Institute on Drug Abuse (NIDA), a civilian agency, to Southern Research Institute, a non-profit organization. The $1,593,565.26 contract is under the Pharmacology and Toxicology for Neurotherapeutics Program (PTNP) indefinite delivery/indefinite quantity (IDIQ) contract vehicle. The contract is for the 28-day oral toxicity study in monkeys with a 33-day recovery period. Southern Research Institute has subcontracted a...

This delivery order was awarded by the National Institutes of Health's National Center for Advancing Translational Sciences to IIT Research Institute under the CRO Support for NCATS In Vitro and In Vivo Toxicology Studies contract vehicle. IIT Research Institute will perform a single-dose cardiovascular and pulmonary safety pharmacology study of Metarrestin in telemetered beagle dogs using a Latin square crossover study design. The $130,092.52 cost-plus-fixed-fee contract is funded by...

This is a cost-plus-fixed-fee delivery order contract awarded by the National Cancer Institute (NCI), a civilian agency, to the University of Illinois. The contract is valued at $761,043.02 and is part of the larger "Toxicology of Drugs Developed for Cancer Patients" indefinite delivery/indefinite quantity (IDIQ) contract vehicle. The purpose of this award is to conduct pre-clinical toxicology studies of a drug candidate, specifically DNA methyltransferase-TdCyd, for potential use in...

This is a $983,066 firm fixed price delivery order awarded by the Food and Drug Administration (FDA) to Altasciences Clinical Kansas Inc., a contract research organization, to conduct a bioequivalence study of lamotrigine extended release tablets. The delivery order was issued against an existing $21 million single-award indefinite delivery contract with the National Institute on Drug Abuse (NIDA) for pharmacokinetic and pharmacodynamic trials to develop medications for substance use...

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences awarded a $268,799.00 delivery order contract to Sri International for non-clinical safety assessment of ORC-13661 to support aminoglycoside induced hearing loss indication. Sri International will perform the work as the prime contractor in West Menlo Park, California from September 14, 2022 through November 13, 2023. Bioivt, LLC will serve as a subcontractor providing a...

The National Institutes of Health's National Center for Advancing Translational Sciences awarded a $913,177 delivery order against its CRO Support for NCATS In Vitro and In Vivo Toxicology Studies master IDIQ contract to IIT Research Institute. IIT Research Institute, operating as the research and programs division of the Illinois Institute of Technology, will conduct three-month subcutaneous toxicity studies in dogs and mice to support the Center's drug development programs. Performance will...