Not listed SPACEFLIGHT EXPOSES CREWS TO UNUSUAL LIGHT-DARK AND WORK SCHEDULES THAT LEAD TO MISALIGNMENT OF THE CIRCADIAN PACEMAKER RESULTING IN POOR SLEEP IMPAIRED NESS AND INCREASED RISK OF FATIGUE-RELATED ACCIDENTS. SPACEFLIGHT IS ALSO ASSOCIATED WITH SHORT SLEEP (ONLY 6H/NIGHT) AND SO EVEN IN NON-SHIFTED SETTINGS SUCH CHRONIC SLEEP DEFICIENCY WILL LEAD TO IMPAIRED PERFORMANCE. RECENTLY WE AND OTHERS HAVE SHOWN THAT SHORT-WAVELENGTH (BLUE) LIGHT IS THE MOST EFFECTIVE WAVELENGTH FOR ENHANCING NESS AND PERFORMANCE DIRECTLY AND FOR PHASE-SHIFTING THE CIRCADIAN PACEMAKER. LIGHT THEREFORE HAS THE POTENTIAL TO BE A SAFE NON-PHARMACOLOGICAL COUNTERMEASURE TO REDUCE THE RISK OF PERFORMANCE DEFICITS AND CIRCADIAN MISALIGNMENT DURING SPACE FLIGHT. USING BLUE LIGHT ALONE HOWEVER IS UNDESIRABLE AS IT IMPAIRS VISUAL FUNCTION BUT MANIPULATION OF THE BLUE LIGHT CONTENT OF WHITE LIGHT HAS SIMILAR BENEFITS AND CAN OPTIMIZE VISUAL AND NON-VISUAL LIGHT RESPONSES SIMULTANEOUSLY. NASA IS REPLACING THE CURRENT LIGHTING ABOARD THE INTERNATIONAL SPACE STATION WITH A NEW SOLID STATE LIGHTING ASSEMBLY (SSLA) INCORPORATING THREE PRE-DETERMINED SETTINGS TO ADDRESS DIFFERENT OPERATIONAL NEEDS: 1) WHITE LIGHT FOR GENERAL VISION 2) BLUE-ENRICHED HIGH INTENSITY WHITE LIGHT TO ENHANCE NESS AND CIRCADIAN ADAPTATION 3) BLUE-DEPLETED LOW INTENSITY WHITE LIGHT TO MINIMIZE NESS PRIOR TO SLEEP. WE HAVE DEVELOPED A DYNAMIC LIGHTING SCHEDULE (DLS) WHICH DETERMINES WHEN EACH OF THESE THREE SETTINGS WILL BE USED TO OPTIMIZE LIGHTING TO IMPROVE NESS AND PERFORMANCE RESET CIRCADIAN RHYTHMS AND ENHANCE SLEEP WHILE MAINTAINING VISION. LABORATORY-BASED ANALOG STUDIES OF THE DLS ARE ONGOING. THE CURRENT PROPOSAL WILL EXTEND THIS WORK TO APPLY THE DLS IN THE HUMAN EXPLORATION RESEARCH ANALOG(HERA) AS THE NEXT STEP IN EXAMINING THE FEASIBILITY AND EFFICACY OF THE SSLA SYSTEM AND TO PROVIDE THE TESTING NECESSARY TO FINALIZE THE OPERATIONAL PROCEDURES FOR IN-FLIGHT TESTING OF THE NEW LIGHT ABOARD ISS IN 2016. $0 6/26/20 12 SPACEFLIGHT EXPOSES CREWS TO UNUSUAL LIGHT-DARK AND WORK SCHEDULES THAT LEAD TO MISALIGNMENT OF THE CIRCADIAN PACEMAKER, RESULTING IN POOR SLEEP, IMPAIRED NESS AND INCREASED RISK OF FATIGUE-RELATED ACCIDENTS. SPACEFLIGHT IS ALSO ASSOCIATED WITH SHORT SLEEP (ONLY 6H/NIGHT) AND SO EVEN IN NON-SHIFTED SETTINGS, SUCH CHRONIC SLEEP DEFICIENCY WILL LEAD TO IMPAIRED PERFORMANCE. RECENTLY, WE AND OTHERS HAVE SHOWN THAT SHORT-WAVELENGTH (BLUE) LIGHT IS THE MOST EFFECTIVE WAVELENGTH FOR ENHANCING NESS AND PERFORMANCE DIRECTLY, AND FOR PHASE-SHIFTING THE CIRCADIAN PACEMAKER. LIGHT THEREFORE HAS THE POTENTIAL TO BE A SAFE, NON-PHARMACOLOGICAL COUNTERMEASURE TO REDUCE THE RISK OF PERFORMANCE DEFICITS AND CIRCADIAN MISALIGNMENT DURING SPACE FLIGHT. USING BLUE LIGHT ALONE, HOWEVER, IS UNDESIRABLE AS IT IMPAIRS VISUAL FUNCTION BUT MANIPULATION OF THE BLUE LIGHT CONTENT OF WHITE LIGHT HAS SIMILAR BENEFITS, AND CAN OPTIMIZE VISUAL AND NON-VISUAL LIGHT RESPONSES SIMULTANEOUSLY. NASA IS REPLACING THE CURRENT LIGHTING ABOARD THE INTERNATIONAL SPACE STATION WITH A NEW SOLID STATE LIGHTING ASSEMBLY (SSLA), INCORPORATING THREE PRE-DETERMINED SETTINGS TO ADDRESS DIFFERENT OPERATIONAL NEEDS: 1) WHITE LIGHT FOR GENERAL VISION 2) BLUE-ENRICHED HIGH INTENSITY WHITE LIGHT TO ENHANCE NESS AND CIRCADIAN ADAPTATION 3) BLUE-DEPLETED LOW INTENSITY WHITE LIGHT TO MINIMIZE NESS PRIOR TO SLEEP. WE HAVE DEVELOPED A DYNAMIC LIGHTING SCHEDULE (DLS) WHICH DETERMINES WHEN EACH OF THESE THREE SETTINGS WILL BE USED TO OPTIMIZE LIGHTING TO IMPROVE NESS AND PERFORMANCE, RESET CIRCADIAN RHYTHMS AND ENHANCE SLEEP, WHILE MAINTAINING VISION. LABORATORY-BASED ANALOG STUDIES OF THE DLS ARE ONGOING. THE CURRENT PROPOSAL WILL EXTEND THIS WORK TO APPLY THE DLS IN THE HUMAN EXPLORATION RESEARCH ANALOG(HERA) AS THE NEXT STEP IN EXAMINING THE FEASIBILITY AND EFFICACY OF THE SSLA SYSTEM, AND TO PROVIDE THE TESTING NECESSARY TO FINALIZE THE OPERATIONAL PROCEDURES FOR IN-FLIGHT TESTING OF THE NEW LIGHT ABOARD ISS IN 2016. Other Administrative Action $0 6/26/20 Not listed SPACEFLIGHT EXPOSES CREWS TO UNUSUAL LIGHT-DARK AND WORK SCHEDULES THAT LEAD TO MISALIGNMENT OF THE CIRCADIAN PACEMAKER RESULTING IN POOR SLEEP IMPAIRED ALERTNESS AND INCREASED RISK OF FATIGUE-RELATED ACCIDENTS. SPACEFLIGHT IS ALSO ASSOCIATED WITH SHORT SLEEP (ONLY 6H/NIGHT) AND SO EVEN IN NON-SHIFTED SETTINGS SUCH CHRONIC SLEEP DEFICIENCY WILL LEAD TO IMPAIRED PERFORMANCE. RECENTLY WE AND OTHERS HAVE SHOWN THAT SHORT-WAVELENGTH (BLUE) LIGHT IS THE MOST EFFECTIVE WAVELENGTH FOR ENHANCING ALERTNESS AND PERFORMANCE DIRECTLY AND FOR PHASE-SHIFTING THE CIRCADIAN PACEMAKER. LIGHT THEREFORE HAS THE POTENTIAL TO BE A SAFE NON-PHARMACOLOGICAL COUNTERMEASURE TO REDUCE THE RISK OF PERFORMANCE DEFICITS AND CIRCADIAN MISALIGNMENT DURING SPACE FLIGHT. USING BLUE LIGHT ALONE HOWEVER IS UNDESIRABLE AS IT IMPAIRS VISUAL FUNCTION BUT MANIPULATION OF THE BLUE LIGHT CONTENT OF WHITE LIGHT HAS SIMILAR BENEFITS AND CAN OPTIMIZE VISUAL AND NON-VISUAL LIGHT RESPONSES SIMULTANEOUSLY. NASA IS REPLACING THE CURRENT LIGHTING ABOARD THE INTERNATIONAL SPACE STATION WITH A NEW SOLID STATE LIGHTING ASSEMBLY (SSLA) INCORPORATING THREE PRE-DETERMINED SETTINGS TO ADDRESS DIFFERENT OPERATIONAL NEEDS: 1) WHITE LIGHT FOR GENERAL VISION; 2) BLUE-ENRICHED HIGH INTENSITY WHITE LIGHT TO ENHANCE ALERTNESS AND CIRCADIAN ADAPTATION; 3) BLUE-DEPLETED LOW INTENSITY WHITE LIGHT TO MINIMIZE ALERTNESS PRIOR TO SLEEP. WE HAVE DEVELOPED A DYNAMIC LIGHTING SCHEDULE (DLS) WHICH DETERMINES WHEN EACH OF THESE THREE SETTINGS WILL BE USED TO OPTIMIZE LIGHTING TO IMPROVE ALERTNESS AND PERFORMANCE RESET CIRCADIAN RHYTHMS AND ENHANCE SLEEP WHILE MAINTAINING VISION. LABORATORY-BASED ANALOG STUDIES OF THE DLS ARE ONGOING. THE CURRENT PROPOSAL WILL EXTEND THIS WORK TO APPLY THE DLS IN THE HUMAN EXPLORATION RESEARCH ANALOG(HERA) AS THE NEXT STEP IN EXAMINING THE FEASIBILITY AND EFFICACY OF THE SSLA SYSTEM AND TO PROVIDE THE TESTING NECESSARY TO FINALIZE THE OPERATIONAL PROCEDURES FOR IN-FLIGHT TESTING OF THE NEW LIGHT ABOARD ISS IN 2016. $0 6/8/19 11 SPACEFLIGHT EXPOSES CREWS TO UNUSUAL LIGHT-DARK AND WORK SCHEDULES THAT LEAD TO MISALIGNMENT OF THE CIRCADIAN PACEMAKER, RESULTING IN POOR SLEEP, IMPAIRED ALERTNESS AND INCREASED RISK OF FATIGUE-RELATED ACCIDENTS. SPACEFLIGHT IS ALSO ASSOCIATED WITH SHORT SLEEP (ONLY 6H/NIGHT) AND SO EVEN IN NON-SHIFTED SETTINGS, SUCH CHRONIC SLEEP DEFICIENCY WILL LEAD TO IMPAIRED PERFORMANCE. RECENTLY, WE AND OTHERS HAVE SHOWN THAT SHORT-WAVELENGTH (BLUE) LIGHT IS THE MOST EFFECTIVE WAVELENGTH FOR ENHANCING ALERTNESS AND PERFORMANCE DIRECTLY, AND FOR PHASE-SHIFTING THE CIRCADIAN PACEMAKER. LIGHT THEREFORE HAS THE POTENTIAL TO BE A SAFE, NON-PHARMACOLOGICAL COUNTERMEASURE TO REDUCE THE RISK OF PERFORMANCE DEFICITS AND CIRCADIAN MISALIGNMENT DURING SPACE FLIGHT. USING BLUE LIGHT ALONE, HOWEVER, IS UNDESIRABLE AS IT IMPAIRS VISUAL FUNCTION BUT MANIPULATION OF THE BLUE LIGHT CONTENT OF WHITE LIGHT HAS SIMILAR BENEFITS, AND CAN OPTIMIZE VISUAL AND NON-VISUAL LIGHT RESPONSES SIMULTANEOUSLY. NASA IS REPLACING THE CURRENT LIGHTING ABOARD THE INTERNATIONAL SPACE STATION WITH A NEW SOLID STATE LIGHTING ASSEMBLY (SSLA), INCORPORATING THREE PRE-DETERMINED SETTINGS TO ADDRESS DIFFERENT OPERATIONAL NEEDS: 1) WHITE LIGHT FOR GENERAL VISION; 2) BLUE-ENRICHED HIGH INTENSITY WHITE LIGHT TO ENHANCE ALERTNESS AND CIRCADIAN ADAPTATION; 3) BLUE-DEPLETED LOW INTENSITY WHITE LIGHT TO MINIMIZE ALERTNESS PRIOR TO SLEEP. WE HAVE DEVELOPED A DYNAMIC LIGHTING SCHEDULE (DLS) WHICH DETERMINES WHEN EACH OF THESE THREE SETTINGS WILL BE USED TO OPTIMIZE LIGHTING TO IMPROVE ALERTNESS AND PERFORMANCE, RESET CIRCADIAN RHYTHMS AND ENHANCE SLEEP, WHILE MAINTAINING VISION. LABORATORY-BASED ANALOG STUDIES OF THE DLS ARE ONGOING. THE CURRENT PROPOSAL WILL EXTEND THIS WORK TO APPLY THE DLS IN THE HUMAN EXPLORATION RESEARCH ANALOG(HERA) AS THE NEXT STEP IN EXAMINING THE FEASIBILITY AND EFFICACY OF THE SSLA SYSTEM, AND TO PROVIDE THE TESTING NECESSARY TO FINALIZE THE OPERATIONAL PROCEDURES FOR IN-FLIGHT TESTING OF THE NEW LIGHT ABOARD ISS IN 2016. Other Administrative Action $0 6/8/19 10 SPACEFLIGHT EXPOSES CREWS TO UNUSUAL LIGHT-DARK AND WORK SCHEDULES THAT LEAD TO MISALIGNMENT OF THE CIRCADIAN PACEMAKER, RESULTING IN POOR SLEEP, IMPAIRED ALERTNESS AND INCREASED RISK OF FATIGUE-RELATED ACCIDENTS. SPACEFLIGHT IS ALSO ASSOCIATED WITH SHORT SLEEP (ONLY 6H/NIGHT) AND SO EVEN IN NON-SHIFTED SETTINGS, SUCH CHRONIC SLEEP DEFICIENCY WILL LEAD TO IMPAIRED PERFORMANCE. RECENTLY, WE AND OTHERS HAVE SHOWN THAT SHORT-WAVELENGTH (BLUE) LIGHT IS THE MOST EFFECTIVE WAVELENGTH FOR ENHANCING ALERTNESS AND PERFORMANCE DIRECTLY, AND FOR PHASE-SHIFTING THE CIRCADIAN PACEMAKER. LIGHT THEREFORE HAS THE POTENTIAL TO BE A SAFE, NON-PHARMACOLOGICAL COUNTERMEASURE TO REDUCE THE RISK OF PERFORMANCE DEFICITS AND CIRCADIAN MISALIGNMENT DURING SPACE FLIGHT. USING BLUE LIGHT ALONE, HOWEVER, IS UNDESIRABLE AS IT IMPAIRS VISUAL FUNCTION BUT MANIPULATION OF THE BLUE LIGHT CONTENT OF WHITE LIGHT HAS SIMILAR BENEFITS, AND CAN OPTIMIZE VISUAL AND NON-VISUAL LIGHT RESPONSES SIMULTANEOUSLY. NASA IS REPLACING THE CURRENT LIGHTING ABOARD THE INTERNATIONAL SPACE STATION WITH A NEW SOLID STATE LIGHTING ASSEMBLY (SSLA), INCORPORATING THREE PRE-DETERMINED SETTINGS TO ADDRESS DIFFERENT OPERATIONAL NEEDS: 1) WHITE LIGHT FOR GENERAL VISION; 2) BLUE-ENRICHED HIGH INTENSITY WHITE LIGHT TO ENHANCE ALERTNESS AND CIRCADIAN ADAPTATION; 3) BLUE-DEPLETED LOW INTENSITY WHITE LIGHT TO MINIMIZE ALERTNESS PRIOR TO SLEEP. WE HAVE DEVELOPED A DYNAMIC LIGHTING SCHEDULE (DLS) WHICH DETERMINES WHEN EACH OF THESE THREE SETTINGS WILL BE USED TO OPTIMIZE LIGHTING TO IMPROVE ALERTNESS AND PERFORMANCE, RESET CIRCADIAN RHYTHMS AND ENHANCE SLEEP, WHILE MAINTAINING VISION. LABORATORY-BASED ANALOG STUDIES OF THE DLS ARE ONGOING. THE CURRENT PROPOSAL WILL EXTEND THIS WORK TO APPLY THE DLS IN THE HUMAN EXPLORATION RESEARCH ANALOG(HERA) AS THE NEXT STEP IN EXAMINING THE FEASIBILITY AND EFFICACY OF THE SSLA SYSTEM, AND TO PROVIDE THE TESTING NECESSARY TO FINALIZE THE OPERATIONAL PROCEDURES FOR IN-FLIGHT TESTING OF THE NEW LIGHT ABOARD ISS IN 2016. Funding Only Action $20.9k 2/27/19