Grant For Research 80NSSC17K0425
- Not listed
- The University of Arkansas for Medical Sciences (UAMS) was awarded a $965,940 research grant by a civilian federal agency to investigate gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects. The project, designated 17-BPBA_2-0092, will utilize 366 genetically modified TRP53ΔP/ΔP mice obtained from an in-house breeding colony at UAMS, with breeders provided by collaborators at the University...
- This $179,871.47 federal grant award to Texas A&M University was issued by the National Aeronautics and Space Administration (NASA) to study the effects of space radiation and microgravity on the cardiovascular system. The research aims to understand how space flight imposes unique stressors on astronauts, particularly the damage and fibrosis that can occur in the heart and vasculature due to radiation exposure. The grant will fund a series of mouse studies using X-ray, heavy ion, and...
- This is a $2,478,052.00 grant award from the National Aeronautics and Space Administration (NASA) to the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, Texas. The grant is part of NASA's "MOUSE MODELS OF CANCER RISK AND PREVENTION FROM SPACE RADIATION" program and supports research on the molecular effects of low-dose space radiation exposure. The objective is to use mouse models to understand how different types and doses of radiation impact the...
- The National Aeronautics and Space Administration (NASA) awarded a $150,000 grant to the University of Arizona (doing business as the Arizona Board of Regents) to conduct research on the effects of simulated microgravity on the anti-tumor activity of human natural killer (NK) cells and gamma-delta T (GD-T) cells in a humanized mouse model. The goal is to determine if impaired immune system function during long-duration spaceflight could increase cancer and viral infection risks for exploration...
- This is a $300,000.00 grant awarded by the National Aeronautics and Space Administration (NASA) to The Ohio State University to conduct research on reducing the uncertainty in estimates of cancer and cardiovascular risks from space radiation. The study will evaluate changes in molecular biomarkers in rodents and rabbits exposed to radiation relevant to astronaut exposures. Archived tissue samples will be analyzed using modern analytical technologies and rigorous statistical methods to examine...
- This is a $947,315.00 grant awarded by the National Aeronautics and Space Administration (NASA) to The Research Foundation for the State University of New York (Stony Brook University) to test the efficacy of the dietary supplement apigenin (AP) for preventing and mitigating cancer due to space radiation exposure. The primary goal is to investigate whether AP can suppress radiation-induced inflammation and oxidative stress during the initiation and promotion stages of carcinogenesis. The study...
- This is a $821,751 grant award from the National Aeronautics and Space Administration (NASA) to the University of Texas Health Science Center at San Antonio (UTHSCSA) to conduct research on cancer risks from galactic cosmic rays and solar particle events for astronauts on prolonged space missions. UTHSCSA, a state-controlled institution of higher learning within the University of Texas System, will utilize transgenic mouse models to study the genetic and molecular mechanisms underlying...
- Duke University's Office of Research Administration has been awarded an $800,000 research grant by the NASA Shared Services Center, with a completion date of November 30, 2026. This non-set-aside grant supports a multi-disciplinary investigation into the cardiovascular effects of environmental stressors encountered during space exploration, specifically examining the individual and combined impacts of galactic cosmic radiation and weightlessness on cardiac biology. The research leverages two...
- This $174,992.99 grant was awarded by the National Aeronautics and Space Administration (NASA) to The Children's Hospital of Philadelphia Research Institute to conduct research on the effects of galactic cosmic radiation (GCR) on cognitive function in mice and evaluate the potential mitigating effects of the anti-inflammatory compound CDDO-EA. The research aims to better understand the acute and long-term central nervous system risks for astronauts exposed to GCR, which is an unavoidable...
- This is a $2,399,358.99 grant awarded by the National Aeronautics and Space Administration (NASA) to Emory University in Atlanta, Georgia to conduct research on the health effects of exposure to galactic cosmic radiation (GCR). The research aims to better understand the mechanisms by which GCR, particularly its high charge and energy (HZE) particle components, can lead to chronic DNA damage and impairment of DNA repair machinery, which may contribute to increased cancer risk for astronauts on...
This is a grant awarded by the National Aeronautics and Space Administration (NASA) Shared Services Center to the University of Arkansas for Medical Sciences (UAMS) to conduct research on the effects of aspirin on tumor formation, cardiac function, and cardiac tissue remodeling in mice exposed to simulated space radiation. The grant has a total potential value of $213,984.00. The research study involves exposing male C3H mice to either a single dose of silicon-28 (28Si) radiation at Brookhaven National Laboratory and administering aspirin, or chronic low-dose neutron radiation at Colorado State University and administering aspirin. The primary endpoint is tumor formation, and the researchers will also assess cardiac function and tissue remodeling in these mice. There is no set-aside designation for this grant, and it was awarded directly to UAMS as the prime recipient on August 7, 2017, with a completion date of January 6, 2020.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| P00003 | Other Administrative Action | $0 | 7/15/19 | |
| Not listed | $0 | 7/15/19 | ||
| Not listed | $63.1k | 3/15/19 | ||
| P00002 | Funding Only Action | $63.1k | 3/15/19 | |
| P00001 | Funding Only Action | $50.0k | 9/19/18 |