This federal contract award was granted by the National Aeronautics and Space Administration (NASA) to the Salk Institute for Biological Studies, a non-profit research institute in La Jolla, California. The $151,465.00 grant is for research aimed at understanding the origin of life on Earth and using that knowledge to guide the search for life elsewhere in the universe. The proposed work involves constructing RNA-based life forms in the laboratory that can replicate and evolve, providing a...
This is a grant award from the National Aeronautics and Space Administration (NASA) Shared Services Center to The Salk Institute for Biological Studies, a non-profit research organization in San Diego, California. The $1,000,379.00 grant is for a project titled "EVOLUTION OF CATALYTIC RNA AND THE ORIGINS OF LIFE" with a period of performance through May 10, 2025. The grant supports fundamental biological research to investigate the molecular origins of life, particularly the role of...
This is a research grant awarded by the National Aeronautics and Space Administration (NASA) to the Foundation For Applied Molecular Evolution, Inc., a non-profit research organization, to support work related to understanding the origins of life. The $585,961 grant supports experimental research on the "RNA First" model for the prebiotic formation of RNA, building on the "Discontinuous Synthesis Model" (DSM) and exploring challenges that must be resolved for the DSM to be...
This is a $579,621.99 grant awarded by the National Aeronautics and Space Administration (NASA) to the University of California, San Diego (UCSD) to conduct research on the emergence of an RNA world. The grant supports two specific aims: 1) studying how prebiotically formed peptides may have influenced the rise and function of catalytic RNA ribozymes, and 2) investigating how nucleoside triphosphates could have been generated from free nucleosides and trimetaphosphate in an early RNA world...
The University of California, San Diego (UCSD), represented by its Office of Contract & Grant Administration, was awarded a $514,057 grant from the National Aeronautics and Space Administration (NASA) to investigate the conditions that could have led to the emergence of an early life form on Earth or other planets. The research will focus on the "RNA world hypothesis," which proposes that organisms using RNA as their genome and catalyst preceded today's DNA/RNA/protein-based life...
This is a $2,000,000.00 grant award to the Scripps Research Institute, a renowned nonprofit biomedical research organization in La Jolla, California. The award, from the National Aeronautics and Space Administration (NASA), is for a research project titled "Comprehending Why RNA by Investigating the Primitive Contemporaries of RNA." The contract is a non-set-aside grant for research with an ultimate completion date of March 10, 2028. Scripps Research Institute, which frequently...
This is a $437,506 grant award to Rensselaer Polytechnic Institute (RPI) by the National Aeronautics and Space Administration (NASA) for research on abiotic RNA polymerization in early Earth environments. The research aims to investigate plausible pathways for the emergence of life on Earth and potential implications for extraterrestrial life, focusing on the challenge of achieving prebiotically feasible RNA polymerization. The project will explore alternative, more general and robust...
This is a $150,000.00 grant awarded by the National Aeronautics and Space Administration (NASA) to The Salk Institute for Biological Studies, a non-profit research organization located in La Jolla, California. The grant will fund research to develop automated deep learning algorithms for quantifying rodent behavior and health phenotypes during spaceflight missions. This research supports NASA's efforts to monitor the effects of spaceflight on animal physiology and is not associated with any...
This is a research grant awarded by the National Aeronautics and Space Administration (NASA) to the University of California, Santa Barbara (UCSB) for the study of ribozymes and their evolvability. The $593,517.90 grant, part of NASA's Exobiology program, aims to map the fitness landscape of aminoacylation ribozymes to gain quantitative insights into their de novo emergence, optimization, and ability to evolve new functions. The research focuses on the potential role of ribozymes in the...
This is a $911,716 grant award from the National Aeronautics and Space Administration (NASA) to the Scripps Research Institute, a nonprofit biomedical research organization based in La Jolla, California. The grant is focused on investigating the role of cyanide and aldehydes in prebiotic chemistry and the development of proto-metabolic pathways, which are key objectives under NASA's Exobiology research emphasis. Specifically, the research aims to systematically explore cyanide-mediated systems...
This is a $924,030.00 grant awarded by the National Aeronautics and Space Administration (NASA) to the Salk Institute for Biological Studies, a non-profit research institution located in La Jolla, California. The grant is part of NASA's effort to understand the origin of life on Earth, which will guide the search for life elsewhere in the universe. The research aims to construct RNA-based life in the laboratory, represented by populations of RNA enzymes that can catalyze their own replication and undergo Darwinian evolution. Key objectives include enhancing the rate, fidelity, and sequence generality of an RNA polymerase ribozyme, as well as exploring a "divide-and-conquer" approach to synthesize larger and more complex RNA enzymes. This research could provide insights into the transition from RNA to DNA-based genomes during the early history of life on Earth. The grant does not have a set-aside designation and was awarded on March 19, 2019, with a completion date of March 18, 2022.