To procure synthetic guide RNA

This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with Synthego of Redwood City, CA. To procure synthetic guide RNA.

# Description
Bioburden testing
Endotoxin testing
Identity by mass spec
Purity determined by analytical HPLC
All synthetic gRNAs are animal origin free.

The Laboratory of Clinical Immunology and Microbiology (LCIM) requires this synthetic guide RNA that is specific to the clinical grade material that is specific to the disease targeted in this project, and is custom made fromm synthego for the specific projectto permit CRISPR-mediated gene editing for targeted correction of CGD in a clinical trial.. To maintain research integrity, with patient studies, it is critical that new variables are NOT introduced to the study. Support of the Division of Intramural Research, NIAID, NIH. Place of delivery is Bethesda, MD 20892.

The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide comparable services may submit a capability statement that will be considered by email (subject line to reference NOI-RML-D-1925946) to Calvin Robinson at calvin.robinson@nih.gov, by 5:00 pm eastern standard time Saturday, Sept, 172018 . All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.

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