nVoke Integrated Imaging and Optogenetics System

This is a Notice of Intent, not a request for proposal.  The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with Inscopix Inc. at 1212 Terra Bella Ave, Mountain View, California 94043, for the following:

1. 1x Qty; Part#1000-004339; Part Name: nVoke 2.0 Integrated Imaging and Optogenetics System for In Vivo Research; Description:

• 1 x nVoke Integrated Imaging and Optogenetics System for In Vivo Research A platform for simultaneous or sequential visualization of large-scale neural circuit dynamics and optogenetic manipulation in the same FOV. Includes miniature microscope with optogenetic capability, data acquisition box, and nVoke acquisition software.
• 1 x Standard Warranty One (1) year standard manufacturing warranty.
• 3 x Inscopix Data Processing Software (IDPS) License Software for identifying cells and their individual dynamics from Inscopix data with a validated processing pipeline and an intuitive user interface.
• 1 x ProView™ Implant Kit - ProView Implant Kit stabilizes and streamlines the lens implant procedure. Includes a lens holding device, stereotax rod, screw, adjustment tool, and instructions.
• Technical Support - Prompt, knowledgeable responses to product hardware, software and technical questions.
• iQ Access-  Central location for learning resources, self-serve support, webstore and more.
• Standard Scientific - Scientific support via email, phone, and video conference for critical stages of your experiments, such as reagent strategy, lens implantation, and data extraction with Inscopix Data Processing software.

2. 1x Qty; Part#1000-004377; Part Name: Application Module; Description: 5 baseplate covers and 1 dummy scope.

3. 1x Qty; Part#1000-002390; Part Name: Field Scientific Consultant On-Site Training; Description: On-site multiple day training with follow-on availability for consultation by Inscopix Field Scientific Consultant.

4. 1x Qty; Part#1050-004415; Part Name: ProView Integrated Lens 0.5mm x 6.1mm; Description: Set of 5 Baseplates with attached GRIN Lenses 0.5mm diameter, 6.1mm length (Jin Lab Free Pack of Lenses)

5. 1x Qty; Part#1050-002917; Part Name: ProView™ Practice Probes 0.5mm diameter, ~6.1mm length; Description: Set of 5 ProView Practice Probes, 0.5mm diameter, ~6.1mm length (Jin Lab Free Pack of Practice Probes)

6. 1x Qty; Part#000-005088; Part Name: Inscopix Commutator System; Description: A commutator system to transfer high-speed video and signal and to minimize cable entanglement. Includes: active commutator system compatible with nVista 3.0,nVoke 2.0 and nVue systems, and commutator cable.

1x Wire Perch

1x Cable Sheath Kit

Optional item

7. 1x Qty; Part#1000-002897; Part Name: Inscopix Care (1-year subscription); Description: Includes: - Free repairs and/or replacements for ANY hardware damage, whether caused by user, animal, or unknown - Complimentary overnight shipping to and from Inscopix

The National Institute of Allergy and Infectious Diseases (NIAID)’s Laboratory of Host Immunity and Microbiome (LHIM), Neuro-immune Crosstalk Unit (collectively “Program”) is engaged in research to understand how neuro-immune interactions contribute to the modulation of immune responses and body physiology. The current project is to decipher how the brain monitors and processes information related to immune responses evoked by different immune challenges at the circuit level. This requires functional imaging of real-time immune-evoked neural activities in selected brain areas with single-neuron resolution in awake mice while simultaneously manipulating the relevant circuit optogenetically. Thus, an integrated imaging and optogenetics system, specifically the nVoke system, is needed for Program’s research.

Very importantly, Program has used the nVista system with Inscopix Inc., to image neural activity.  Members are familiar with the operation of Inscopix Inc., hardware and software, making it easier to transition into the nVoke system. Using the same platform from the same brand that uses the same software will streamline the integration of new data with the existing data obtained from the nVista system. Using a different brand with a different software will not only require additional time & costs for training but may also introduce new variables and result in incompatibilities due to different software. This may prevent Program’s existing data from being used and compared, which may jeopardize Program’s research.

Delivery: NIH-NIAID, Bethesda, Maryland 20814

The statutory authority for this sole source requirement is 41 U.S.C.1901 (e) (2) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL.  All responsible sources that could provide equipment may submit a capability statement that will be considered by email (subject line to reference NOI-NIAID-23-2182064) to Lu Chang

lu-chang.lu@nih.gov by 4:00 PM eastern standard time, on August 31, 2023.  All responses received by the closing date of this synopsis will be considered by the Government.  A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.