LC/MS - qtof mass spectrometer workstation

Added: Jun 15, 2017 3:17 pm This is a SOURCES SOUGHT NOTICE of a proposed requirement to award one (1) Liquid Chromatography-Mass Spectrometry (LC/MS) Quad Time of Flight (QTof) Mass Spectrometer Workstation, or a system equal to or better than the salient characteristics. This notice is issued solely for informational and planning purposes and no offers will be accepted. This action also requires warranties, packaging and shipping.





SALIENT CHARACTERISTICS



The VA Healthcare System Medical Research Service intends to acquire a full-scan mass spectrometer system coupled with chromatographic separation is required to identify, characterize, and quantify lipids in the complex biological samples that are generated by researchers involved in the projects incorporated herein. The workstation shall have the ability to discover and quantify moderately polar metabolites, specifically lipids and closely related compounds. The system shall directly and specifically measure a wide range of lipids and related metabolites providing a unique window into cell and organism state, with applications ranging from identification of novel metabolic pathways, discovery of drug targets, and characterization of diagnostic and prognostic markers of disease. The requirement is for an Agilent Technologies Inc. based system or an equal (or better) system in accordance with the specifications outlined in the solicitation.



#

Item/Stock#

Description

Est. Qty.

Unit

1

G6545AA



Q-TOF LC/MS System includes Q-TOF mass spectrometer, MassHunter Workstation, Monitor, SW, training, installation & familiarization. (or equal)



With the following configuration: Monitor, Printer.



One Year Update/Phone Assist and PC Repair Recovery Service.

1

EA

2

G7120A



1290 Infinity II High Speed Pump. Power range 1300 bar and 5ml/min flow, binary high pressure mixing, lowest delay, highest precision and accuracy. Includes Active Seal Wash, Tool Kit, Solvent Cabinet, bottles

and ISET. With the following configuration:

High speed UCT Safe cap, Agilent Lab Advisor Advanced Software, Ultra Clean Tubing Kit, A-Line Stay Safe Cap Starter Kit, Delete ISET, Installation (44K)

(or equal)

1

EA

3

01018-60025



Solvent inlet filter, stainless steel (or equal)

5

EA

4

G7167B



1290 Infinity Multi-sampler up to 1300 bar

for well plates and individual sample containers. Include 1 sample drawer, 2x 54-vial containers, a needle flush

port, 40 uL metering device, 20 uL loop. (Dual-needle instruments metering is100 ul and loop size is 100 ul).

With the following configuration:

Dual-height drawer kit: 4

Sample Loop-Flex 40 uL : Sample Loop-Flex 40 uL right

Sample cooler

Dual-height drawer

Sample Loop-Flex (or equal)



1

EA

5

G7116B



1290 Infinity II Multicolumn Thermostat. Capacity up to 8 columns, temperature range 4 deg C. to 110 deg C. Includes 1.6uL Quick-Connect Heat Exchanger, Quick-Connect fitting and two Quick-Turn fittings.

With the following configuration:

Valve drive for 1290 MCT

Quick-Connect HE Standard Flow

Installation (or equal)

1

EA

6

G1170A

1290 Infinity Valve Drive Supporting QuickChange valve heads, built-in power supply. (or equal)

1

EA

7

G4232D

2 Pos/10 Port valve head cap kit, 1300 bar With the following configuration: Kap kit QCHE (005) : 0.12 mm ID, incl. QC-HE, Installation (or equal)

1

EA

8

G4234A

Multi-column selection valve head 600bar.

Includes 600 bar QuickChange valve head for up to 6-column selection. Capillary kit optional. (or equal)

1

EA

9

G4301A

1260 Infinity II SFC Control Module. Includes CO2 booster pump and back-pressure regulator for solvent

pre- and post-conditioning. (or equal)

1

EA

10

5190-0584

(or equal)

1

EA

11

G4782A

1260 Infinity II SFC Binary Pump. Maximum pressure 600 bar. Includes SFC Binary Pump with integrated 2-channel

degassing unit, SSV, Seal-wash, Solvent Cabinet, Solvent Bottles and CAN cable. With the following configuration: Tool Kit, Max uptime kit.

HPLC system tool kit 1260 Infinity II

Agilent Lab Advisor Advance Software

1260 Infinity II Max Uptime (or equal)

1

EA

12

G4767A

1260 Infinity II SFC Multisampler 600 bar. Includes 2 sample drawers (2H) and 2x 54-vial containers.

With the following configuration: Dual-height drawer kit (132) : 4

Agilent Infinity II Sample Cooler

Dual-height drawer (2H) kit. (or equal)

1

EA

13

G7116A

1260 Infinity II Multicolumn Thermostat MCT

With the following configuration: Quick-Connect HE 3ul,

Column upgrade kit. (or equal)

1

EA

14

G7116-60006

Divider Assembly-MCT (or equal)

1

EA

15

G7110B

1260 Infinity II Isocratic Pump, max pressure 600bar. Include isocratic pump, column, connecting

capillaries, solvent cabinet, solvent bottles and CAN cable.

With the following configuration:

Bundled column : Poroshell 120 EC-C18 3.0x50mm

Poroshell 120 EC-C18 3.0x50mm, 2.7 m



2

EA

16

G4309-68715

SFC/MS Splitter Kit

1



17

G3835AA

Mass Profiler Professional (MPP) (or equal) With the following configuration:

1 Year SW Update/Phone Assist

Training





18



Installation and Training.









Product Specifications



As a minimum, the proposed system shall maintain a unique combination of chromatographic separation and mass spectrometric detection such as:



Electron Spray Ionization (ESI) with the ability to interchange and use existing atmospheric pressure chemical ionization (APCI) source at the Northport VA

High data acquisition rate (> 25hz) while maintaining accurate mass (resolving power > 20,000 at 300m/z) and in-scan dynamic range of > 3 log10.

1. Essential to generate sufficient information across narrow chromatographic peaks in complex biological samples while providing necessary resolution and dynamic range for identification of isotopologues

Tandem mass spectrometry (MS*MS) for precursor isolation and fragmentation

Ultra high pressure liquid chromatography (UHPLC) system integrated to mass spectrometry data acquisition system with the following, at minimum:

Binary pump capable of 1200bar or greater backpressure

AutoSampler capable using 2mL vials and SBS standard well plates

Temperature controlled column compartment with integrated modular switching valve

Supercritical fluid chromatography (SFC) system that can be integrated to the mass spectrometer control software

Autosampler capable of using standard vials or well plates

Temperature controlled column compartment

SFC pressure module, backpressure regulator, and full integration to atmospheric pressure ESI and APCI mass spectrometer interfaces

HPLC pump (single channel minimum) of sufficient pressure and flow to introduce makeup solvent to improve APCI and ESI ionization



Other unique Requirements and Considerations



The mass spectrometer system may require 2 x 30A 208V outlets. The instrument may also require bottle gasses (helium or argon) and high-purity, high-flow nitrogen (up to 60slpm). Instrument exhaust gas, including output from mechanical rough vacuum pump and waste from ionization source, shall be exhausted into fume hood or equivalent non-recirculated air handling system. Instrument will be housed in a space that has a less than 15 F absolute temperature swing, with less than 10 F within a 24h period.



The Veteran s Health Administration Service Area Office - East estimates a posting date of solicitation VA240-17-Q-0168 on June 21, 2017 and distributed solely through the Federal Business Opportunities (FBO) Website (www.fedbizopps.gov). This notice does not constitute a Request for Proposal (RFP) and should not be construed to as a commitment of any kind by the Government to issue a formal solicitation or ultimately award a contract. Responses to this notice are not offers and cannot be accepted by the Government to form a binding contract. Any costs incurred by interested parties will NOT be reimbursed. It is the responsibility of any interested party to monitor this site for additional information pertaining to this notice.

The agency is contemplating single award of a firm fixed price (FFP) contract to the contractor whose submission represents best value to the Government. The intention of this notice is to seek sources that could potentially provide these items under a Service Disabled Veteran Owned Small Business Set-aside, or a Veteran Owned Small Business Set-Aside. Firms with interest and capability to respond to this requirement should develop short (1 page or less) narrative capability statement by email including relevant information indicating and evidencing capability to successfully meet the aforementioned requirements. Responding to this not does not guarantee any opportunity for the contract, and is only used for VA planning purposes. Capability responses will be accepted until 10:00 AM (est) on June 21, 2017.



The North American Industry Classification System code is 334516 Analytical Laboratory Instrument Manufacturing. Interested parties shall be registered in the System for Award Management at (www.sam.gov).



Contracting Office Address:

323 North Shore Dr.

Pittsburgh PA, 15212

United States



Primary Point of Contact:

Michael Haydo

Contracting Officer

Email: michael.haydo@va.gov

Phone: 412-822-3158