K3 Direct Detection Camera with K3 Software Suite

INTRODUCTION
THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Office of Acquisitions (OA) on behalf of the National Institute of Digestive, Diabetes & Kidney Diseases intends to award a purchase order without providing for full and open competition (Including brand-name) to GATAN INC for a 1-year maintenance contract for a K3 Direct Detection Camera with K3 Software Suite (64-bit).

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE
The intended procurement is classified under NAICS code 333314 with a Size Standard of 500.

REGULATORY AUTHORITY
The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-99.

This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000).

STATUTORY AUTHORITY
This acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- FAR 6.302-1-Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1).

PERIOD OF PERFORMANCE
Within 30 Days of Award

Place of Performance
National Institutes of Health
National Institute of Digestive, Diabetes & Kidney Diseases
8 Center Drive
Bethesda MD 20892
 

DESCRIPTION OF REQUIREMENT
CryoEM promises high resolution 3D protein structure solution (sub 3 Angstrom) without the need of crystallization. In recent 5-6 years the field has witnessed a boom with its application to protein structure problems. The CryoEM core currently possesses one Cryo TEM (Tecnai TF20) for Cryo specimen screening purposes that serves about 45 users from MICEF, a surge from less than 10 users 3-4 years ago. Among which ~30 are from within NIDDK. With 1 day of turnover ratio, it takes more than a month for an average user to get his/her turn for screening purposes. This severely hampered the research activities of the NIDDK and associated institutions. On the other hand, the nature of the CryoEM projects typically require ~1 million protein particles or a few thousands of 4Kx4K images for Single Particle reconstructions. All these have exerted tremendous burden on the NIDDK and MICEF CryoEM core facilities.

Glacios from Thermo Scientific is an established Cryo TEM that meets this demand. It offers improved specimen loading efficiency and compatibility with other existing high end Cryo TEM platforms. The high efficiency of Glacios platform calls for a high throughput and high quality Cryo EM camera.

The latest generation Direct Detection camera K3 from Gatan has a frame rate of 1500 frames/second (fps) vs 400 fps for the earlier generation K2 camera, a 3.6X improvement. The total pixels of the imaging area are 23.6 megapixles (5,760 x 4,092) vs 14.4 megapixels (3,838 x 3,710) for K2, a 1.6X improvement. This results in a total of 6.2X improvement over the previous generation K2 camera. This is a perfect match for Glacios Cryo TEM and allows for high throughput screening and data collection. The purchase of the Glacios Cryo TEM together with the K3 camera is expected to help the CryoEM research projects in NIDDK greatly.

K3 - TFS Glacios with TFS housing (Ceta)
Qty Part # Product Name List Price Net Total
1 1025 K3 Direct Detection Camera
Highest performance, 23.6-megapixel, electron-counting direct detection camera for cryo-electron microscopy and other low-dose imaging applications. The camera includes a 94-megapixel super-resolution mode, host computer with dual advanced 8-core processors, 10 TB SSD hard drive, 256 GB RAM, 32" UHD 4k monitor, and 20 m high-speed fiber optic data interface. Gatan installation plus the K3 Camera Housing and Flange (1025.U2) are required. Capabilities and performance specifications are available at www.gatan.com/K3/datasheet.

1 700.LS.1025.00.64.1 K3 Software Suite (64-bit)
Acquisition and analysis software for the K3 camera (64-bit, 1 license). Includes one copy for online use, and one for offline use.
1 1025.U2 K3 Camera Housing and Flange
Camera housing assembly and flange that are compatible with a K3 camera (required for K3 installation).
1 1025.FEI Works with Thermo Fisher Scientific (K3 Cameras)
Required when retrofitting a K3 camera onto an existing Thermo Fisher Scientific TEM, only if no previous Gatan camera is installed. Includes system check and confirmation by Thermo Fisher Scientific engineer to ensure proper preparation of the TEM and performance of this Gatan product during installation. Includes required software and hardware, as necessary, but does not include optional upgrades or system enhancements not covered by the WWF program.
1 1025.T K3 Installation
Includes installation and basic product training performed at the time of install.
 
CLOSING STATEMENT
This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses to this notice shall be submitted electronically by 9:00 am Eastern Standard Time, on Tuesday, July 16, 2019 to the Contract Specialist, Amber Harris, at amber.harris@nih.gov .

Assessment of Capability
Lowest Price Technically Acceptable

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