H&e stained slides

This Small Business Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation or commitment by the Government. This notice is intended strictly for Market Research. The National Institutes of Health (NIH) Eunice Kennedy Shriver, National Institute of Child Health and Human Development is conducting a market survey to determine the availability and technical capability of qualified small business, veteran-owned small business, service-disabled veteran-owned small business or HUBZone small businesses capable of providing H & E-stained slides of mouse brain sections.

Alzheimer's disease (AD) is a common neurodegenerative disease, caused by pathogenic aggregation of amyloid-β (Aβ) peptides and tau proteins in brain tissue. Aβ aggregation is believed to precede and cause tau aggregation. No effective preventions or cures for AD have been demonstrated to date.

The overall objective of this work is to test a possible prevention of AD through experiments on transgenic AD model mice. The specific objective is to obtain slides of immunohistochemically stained brain sections from 3xTg-AD mice that have received intra-ventricular injections of fibril-seeded polyacrylamide microspheres, as well as mice that have received injections of unseeded microspheres and mice that have not received injections (as experimental controls). These slides will be used by NIDDK and collaborators to quantify the effects of treatment on Aβ and tau aggregation in brain tissue.

The intended procurement will be classified under North American Industrial Classification (NAICS) code 541380 with a size standard of $15.0M All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Capability statement must be received at the email address identified in this synopsis by 11:00 A.M. local time on July 30, 2019. Any questions regarding this announcement must be sent via email to verne.griffin@.nih.gov and must include solicitation NICHD-19-141 in the subject line of email.

This synopsis is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation.

Responses to this notice shall contain enough information to establish the interested parties bona-fide capabilities for fulfilling the requirement and include: certification by the OEM that you are authorized to provide services.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation. Confidentiality - No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)." PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System for Award Management (SAM) http://www.sam.gov

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