Chromatography Mass Spectrometer system

The purpose of amendment 1 is to revise the part number for the Mass Spec "S" unit requirement. Therefore, Line Item #3 part number is changed from 685237084 to 685237083. All other terms and conditions remain unchanged.
(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
(ii) The solicitation number is 75N95019Q00077 and the solicitation is issued as a Request for Quotation (RFQ) on a Full and Open competitive basis.

This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items and is expected to exceed the simplified acquisition threshold of $250,000.00. A Fixed-Price type of contract is contemplated for any resulting contract entered into as a result of this solicitation.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Regulation (FAR) Federal Acquisition Circular (FAC) Number/Effective Date: 2019-01 / 01-22-2019.

(iv) The North American Industry Classification System (NAICS) code for this procurement is 334516 Analytical Laboratory Instrument Manufacturing with size standard 1,000 employees.

(v) Background
The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Center for Advancing Translational Sciences (NCATS) is a translational science center whose mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

At the NCATS Chemical Genomics Center (NCGC), there is a significant effort towards automation in chemistry to minimize repetitive manual steps, particularly in preparative purification. Chemists currently utilize flash silica gel chromatography systems. However, medicinal chemists at NCATS do not have access to mass directed purification in either normal or reverse phase purification systems; this forces a tedious manual LCMS analysis of fractions. Bench chemists also do not have access to automated sequential reverse phase purification of multiple samples. In order to prepare for the ramp up in automation, NCATS has a requirement for two (2) Chromatography System Mass Spectrometer systems, integrated to the mass spectrometer which can collect fractions simultaneously using PDA, ELSD and MS, on a Brand-Name-or-Equal basis, meeting or exceeding the performance characteristics, of the subject Mass Spec system described in this notice. Enabling the automated purification of samples with a wide range of polarity and analytical properties will significantly impact the work flow of all chemists within the NCGC chemistry labs at NCATS.

Purpose and Objective: The purpose of this requirement is to obtain to obtain two (2) Chromatography System Mass Spectrometer systems on a BRAND-NAME-OR-EQUAL basis to the Teledyne ISCO CombiFlash EZ Prep chromatography systems and accessories manufactured by Teledyne ISCO, Inc located at 4700 Superior Street, Lincoln, NE 68504. Each CombiFlash EZ Prep Chromatography System Mass Spectrometer needs to be integrated to mass directed purification system and includes an autosampler module for EZPrep, a Mass Spectrometer "S" and ESI Ion Source for Base, S and L Mass Spec options, with onsite installation and training included.

Product Description: Products offered must include those salient physical, functional, or other characteristics that are deemed essential in meeting the government's needs. Specifically, the following must be contained in the requirement and are considered essential features:
1. Purification with active solvent monitoring system that monitors solvent quantity and quality; with an automated detection system that turns off automatically after a solvent spill.
2. Remote software with ability to monitor and control gradients and solvents during purification remotely from their office desks or remotely from home through VPN connection.
3. Purification that detects columns automatically when loaded and automatically load the flow rate, pressure limits and gradient for the run.
4. Purification system with capability to go up to 200psi for Flash separations and 3500psi for HPLC separations and automatically switch between Flash and HPLC runs with automatic purge and switch when going from normal to reverse phase or reverse to normal phase.
5. Internal ELSD, a Mass Spec, for fraction collections via PDA, ELSD and MS simultaneously; ability to collect up four masses between 10-1200 Daltons at 1 Dalton resolution.
6. Mass spec needs to be integrated to the Teledyne ISCO CombiFlash system.

Products offered must be essentially equal to the specified supply described in this solicitation, which specifically includes the following product code, product description and quantity:
1. 685230028; CombiFlash EZ Prep Chromatography System Mass Spec; 2
2. 685237092; AutoSampler Module for EZPrep; 2
3. 685237083; Mass Spectrometer ''S"; 2
4. 250000129; ESI Ion Source for Base, S and L Mass Spec options; 2
5. CHROMINSTALSALES Onsite Installation and Training per segment; 4.

Option years to extend the factory maintenance plan are being requested. Maintenance plan coverage include parts, travel and labor costs for service calls to repair a unit, and one service call to install the preventative maintenance parts kit. Damages determined to be caused by repeated clogs, misuse or neglect are not covered. Consumable parts not included. Service plans must be performed by a manufacturer-authorized, OEM-certified field service engineer possessing the requisite manufacturer-authorized training to ensure proper manufacturer's proprietary software and hardware functioning.

Offerors must clearly indicate if the line item or items being offered in their quote is a brand-name item to the brand name item described in this solicitation, or if the item or items being offered is an "or-equal" item. Shipping and handling cost must be included in any quotation submitted in response to this solicitation.

Offerors must indicate if items being quoted are warrantied in accordance with their standard commercial warranty practices, and the length of time of such warranty. Offerors shall indicate if any applicable extended warranty coverage is only offered at time of purchase in accordance with the Offeror's standard commercial practice, or if warranty is quoted on an optional year basis, priced on a per annum basis, for a total contract warranty period term not to exceed a maximum of five (5) years. If any warranty quoted, in accordance with the Offeror's standard commercial warranty practice, is less than five years, offeror shall also include pricing for extended warranty coverage for a total period not exceeding five (5) years.

Delivery, Inspection and Acceptance: Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or factory warranty schedules in accordance with standard commercial practice, or as applicable. Shipping shall include FOB-DESTINATION terms. Inspection and acceptance will be performed at a Government facility located at 9800 Medical Center Drive, Rockville, MD 20850. The Government expected build time and delivery is 30-60 days after contractor receipt of any contract resulting from this solicitation.

(vi) The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. The following is provided as an addendum to FAR clause 52.212-1, Instructions to Offerors: Installation and any onsite training shall be quoted on separate line items. Shipping and handling cost must be included in any quotation submitted in response to this solicitation. Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or warranty schedules applicable.

(vii) The provision at FAR clause 52.212-2, Evaluation - Commercial Items, applies to this acquisition. The following is an addendum to 52.212-2. Responses received to this RFQ will be evaluated on the basis of Lowest Price Technically Acceptable (LPTA). Offeror's submitting a response must provide a completed Price Quote to be evaluated and considered for award. Price quotes must indicate fixed unit pricing and total cost, including shipping cost and estimated time of delivery after receipt of order, and warranty and training considerations. Responses will be evaluated based on contractor's ability to meet the government's SALIENT CHARACTERISTICS stated in this notice and on ability to deliver required supplies. Responses to this solicitation must include clear and convincing evidence of the Offeror's capability of fulfilling the requirement as it relates to the essential government requirements stated in this solicitation. Under the lowest-price technically acceptable (LPTA) process, Offerors' will be determined to be "technically acceptable" or "technically unacceptable" based on an evaluation of responses against the following factor to determine if, as submitted, the proposal is technically acceptable.

(1) Technical Capability: Offerors shall clearly indicate they possess the technical capability to achieve the essential salient characteristic features of this requirement. The Offeror must indicate in its quotation the ability to provide all of the requirements. The Offeror must indicate in its quotation the ability to meet the delivery requirements. Offerors submitting a response with documented technical specifications and evidence of possessing the technical knowledge, qualifications and capability and management structure needed in successfully achieving this requirement will be determined to be technically acceptable.

Respondents that believe that they are manufacturers or authorized resellers of any BRAND-NAME product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order.

(viii) The provision at FAR Clause 52.212-3, Offeror Representations and Certifications Commercial Items, applies to this acquisition.

(ix) The provision at FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items, applies to this acquisition. An addendum to FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items, Offeror Representations and Certifications Commercial Items, applies to this acquisition. The addendum includes the following FAR Clauses, provisions, terms and conditions: (a) 52.211-6 Brand Name or Equal (Aug 1999), (b) 52.217-7 Option for Increased Quantity-Separately Priced Line Item (Mar 1989)-the Contracting Officer may exercise the option by written notice to the Contractor at any time during the period of performance of the contract.

(x) The provision of FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items applies to this acquisition and the clause at 52.222‐51, Exemption from Application of the Service Contract Act to Contracts for Maintenance, Calibration, or Repair of Certain Equipment‐‐Requirements (Nov 2007) (41 U.S.C. 351, et seq.) applies to this acquisition. The following clauses listed in FAR clause 52.212-5 are applicable to this solicitation:

52.203-6 Restrictions on Subcontractor Sales to the Government (Sept 2006), with Alternate I (Oct
1995)
52.204-10 Reporting Executive Compensation and First-Tier Subcontract Awards (Oct 2016)
52.209-6 Protecting the Government's Interest When Subcontracting with Contractors Debarred,
Suspended, or Proposed for Debarment. (Oct 2015)
52.219-8 Utilization of Small Business Concerns (Nov 2016)
52.219-28 Post Award Small Business Program Rerepresentation (Jul 2013)
52.222-3 Convict Labor (June 2003)
52.222-19 Child Labor-Cooperation With Authorities and Remedies (Jan 2018)
52.222-21 Prohibition of Segregated Facilities (Apr 2015)
52.222-26 Equal Opportunity (Sep 2016)
52.222-35 Equal Opportunity for Veterans (Oct 2015)
52.222-36 Equal Opportunity for Workers With Disabilities (Jul 2014)
52.222-37 Employment Reports on Veterans (FEB 2016)
52.222-40 Notification of Employee Rights Under the National Labor Relations Act (Dec 2010)
52.222-50 Combating Trafficking in Persons (Mar 2015)
52.222-54 Employment Eligibility Verification (OCT 2015)
52.223-18 Encouraging Contractor Policies to Ban Text Messaging While Driving (Aug 2011)
52.225-1 Buy American - Supplies (May 2014)
52.225-13 Restriction on Certain Foreign Purchases (Jun 2008)
52.232-33 Payment by Electronic Funds Transfer-- System for Award Management (Jul. 2013)

In addition, the following FAR provisions are applicable to this solicitation and incorporated by reference: 52.204-7 System for Award Management (Oct 2018), 52.204-13 System for Award Management Maintenance (Oct 2018), 52.204-16 Commercial and Government Entity Code Reporting (Jul 2016), 52.204-18 Commercial and Government Entity Code Maintenance (Jul 2016).

(xi) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition.

(xii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.

(xiii) Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The PRICE QUOTE shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria and a price proposal.

Offerors must include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications Commercial Items, with their offer, or provide a copy of the valid certifications registrations and Representation and Certifications from the System of Award Management (SAM) applications at www.SAM.gov, which may be indicated on the Offeror's cover sheet.

In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

All responses must be received no later than the date specified in this announcement. Late responses will not be accepted. All responses must reference the subject solicitation number. Responses must be submitted electronically to hunter.tjugum@nih.gov. Facsimile responses will not be accepted. For information regarding this solicitation, contact Hunter Tjugum by email at hunter.tjugum@nih.gov or by phone at 301-827-5304.

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