Centralized Omic REsource (CORE) for TOPMed

Added: Mar 29, 2016 3:01 pm Modified: Apr 28, 2016 4:03 pmTrack Changes IGF::OT::IGF B599 OTHER SPECIAL STUDIES & ANALYSES - Sequencing and Profiling services

Added: Mar 29, 2016 3:01 pm Modified: Apr 12, 2016 9:52 pmTrack Changes  

Pre-Solicitation Notice

NHLBI Centralized Omics REsource (CORE) 

The National Heart, Lung, and Blood Institute (NHLBI) is seeking sequencing centers for the five-year Centralized Omics REsource (CORE) program.  The purpose of this announcement is to provide a Presolicitation Notice for the release of Solicitation NHLBI-CSB-HV-2016-36-JS.  THIS IS A SYNOPSIS.  THIS IS NOT A SOLICITATION.

NHLBI's Trans-Omics for Precision Medicine (TOPMed) program seeks to discover factors that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. In addition to providing a comprehensive view of the genetic architecture, an unprecedented rich and multilayered data resource will be available to the scientific community stimulating innovative approaches to examine novel questions and generate cutting-edge methodologies to address heart, lung, blood, and sleep (HLBS) disorders. The program couples Whole Genome Sequencing (WGS) with additional phenotype data using Trans-Omic approaches by generating and incorporating Omics technologies such as DNA methylation, RNA expression patterns, and metabolic profiling with other extant phenotype and clinical outcome data from studies focused on HLBS disorders. The resulting data will be made available to approved investigators.

NHLBI's CORE contract program provides whole genome sequencing and other Omics measures including DNA methylation, RNA expression patterns and metabolic profiling for use with other phenotype and clinical outcome data from studies focused on HLBS disorders. Thus the program in conjunction with NHLBI's TOPMed Program, seeks to discover factors that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. In addition to providing a comprehensive view of genetic, molecular, and cellular architecture, the unprecedented rich data resource generated by CORE will be available to the scientific community stimulating innovative approaches to examine novel questions to address HLBS disorders. 

The objective of this Indefinite Delivery, Indefinite Quantity (IDIQ) contract is to generate Omics data for studies selected by NHLBI for participation in TOPMed. Omics technologies include Large Scale WGS, DNA Methylation, RNA Sequencing, Metabolic Profiling, and Novel Omics Technologies.

This requirement has a goal for 20% of the contracts to be set-aside for small businesses. All interested offerors, both small and large, may submit a proposal. The associated NAICS code for this requirement is 541380, with a small business size standard of $15M

NHLBI plans to establish a multiple award IDIQ as a result of the anticipated solicitation and will issue task orders to the established IDIQ holders. The majority of task orders are anticipated to be Cost Reimbursement.  The IDIQ will be for a five (5) year period of performance and a four and a half (4.5) year ordering period.  Source selection will be based on a best value trade-off evaluation. 

This is not a Request for Proposal (RFP) and the Government is not committed to award a contract pursuant to this announcement.  This advertisement does not commit the Government to award a contract.  The RFP will be available on the FedBizOpps Web page at http://www.fedbizopps.gov. Prospective offerors are responsible for downloading the RFP and all attachments. The offeror is responsible for monitoring the FedBizOpps Web page for the release of the solicitation and any amendments. The RFP will be available from the FedBizOpps on or about April 15, 2016.

Added: Mar 29, 2016 3:01 pm  

Pre-Solicitation Notice

NHLBI Centralized Omics REsource (CORE) 

The National Heart, Lung, and Blood Institute (NHLBI) is seeking sequencing centers for the five-year Centralized Omics REsource (CORE) program.  The purpose of this announcement is to provide a Presolicitation Notice for the release of Solicitation NHLBI-CSB-HV-2016-36-JS.  THIS IS A SYNOPSIS.  THIS IS NOT A SOLICITATION.

NHLBI's Trans-Omics for Precision Medicine (TOPMed) program seeks to discover factors that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. In addition to providing a comprehensive view of the genetic architecture, an unprecedented rich and multilayered data resource will be available to the scientific community stimulating innovative approaches to examine novel questions and generate cutting-edge methodologies to address heart, lung, blood, and sleep (HLBS) disorders. The program couples Whole Genome Sequencing (WGS) with additional phenotype data using Trans-Omic approaches by generating and incorporating Omics technologies such as DNA methylation, RNA expression patterns, and metabolic profiling with other extant phenotype and clinical outcome data from studies focused on HLBS disorders. The resulting data will be made available to approved investigators.

NHLBI's CORE contract program provides whole genome sequencing and other Omics measures including DNA methylation, RNA expression patterns and metabolic profiling for use with other phenotype and clinical outcome data from studies focused on HLBS disorders. Thus the program in conjunction with NHLBI's TOPMed Program, seeks to discover factors that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. In addition to providing a comprehensive view of genetic, molecular, and cellular architecture, the unprecedented rich data resource generated by CORE will be available to the scientific community stimulating innovative approaches to examine novel questions to address HLBS disorders. 

The objective of this Indefinite Delivery, Indefinite Quantity (IDIQ) contract is to generate Omics data for studies selected by NHLBI for participation in TOPMed. Omics technologies include Large Scale WGS, DNA Methylation, RNA Sequencing, Metabolic Profiling, and Novel Omics Technologies.

This requirement is a partial small business set-aside. All interested offerors, both small and large, may submit a proposal. The associated NAICS code for this requirement is 541380, with a small business size standard of $15M

NHLBI plans to establish a multiple award IDIQ as a result of the anticipated solicitation and will issue task orders to the established IDIQ holders. The majority of task orders are anticipated to be Cost Reimbursement.  The IDIQ will be for a five (5) year period of performance and a four and a half (4.5) year ordering period.  Source selection will be based on a best value trade-off evaluation. 

This is not a Request for Proposal (RFP) and the Government is not committed to award a contract pursuant to this announcement.  This advertisement does not commit the Government to award a contract.  The RFP will be available on the FedBizOpps Web page at http://www.fedbizopps.gov. Prospective offerors are responsible for downloading the RFP and all attachments. The offeror is responsible for monitoring the FedBizOpps Web page for the release of the solicitation and any amendments. The RFP will be available from the FedBizOpps on or about April 15, 2016.