AJ15--Nemocell Pala Automated Single Cell Dispenser Analysis System
Closed Special Notice Posted
- Solicitation number
- 36C24E24Q0011
- Agency
- Veterans Integrated Service Network 4 Veterans Health Administration, Department of Veterans Affairs
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 334516 Analytical Laboratory Instrument Manufacturing
Notice details come from SAM.gov. Updated .
About this opportunity
This Special Notice was published by the Department of Veterans Affairs Veterans Health Administration Veterans Integrated Service Network 4. The agency intends to negotiate on a sole source basis with ProteinSimple for the purchase of a Namocell Pala Single Cell Dispenser to support a study assessing candidate molecular mechanisms in traumatic brain injury, neuroinflammatory, and neurodegenerative disorders being conducted by the VA New Jersey Health Care System.
The dispenser will provide dissociated cells as input to a 10X Genomics Chromium Connect system recently acquired under a separate contract to enable single cell RNA sequencing and gene expression analysis for the study. Responses from contractors are due by December 15, 2023 at 11:59 AM Eastern Time. The dispenser must be able to dispense single cells into 96-well or 384-well plates within one or six minutes respectively using low sorting pressure. ProteinSimple is identified as the sole manufacturer and distributor eligible to participate as Namocell, which produces the required dispenser equipment, operates under ProteinSimple.
Notice text
Regional Procurement Office (RPO) - East intends to negotiate on a sole source basis with ProteinSimple to purchase the Namocell Pala Single Cell Dispenser for the VA New Jersey Health Care System (VANJHCS - East Orange). This equipment, in conjunction with the 10X Genomics Chromium Connect, is required for VA-funded study of genetic molecular-based hypotheses testing to assess candidate molecular mechanisms and pursue targets in traumatic brain injury, neuroinflammatory, and neurodegenerative disorders.
STATEMENT OF NEED
Background and Scope
VANJHCS has conducted preclinical research in traumatic brain injury, neuroinflammatory and neurodegenerative disorders. One outcome of VANJHCS preclinical efforts is that a Phase I trial is scheduled to evaluate a VANJHCS candidate molecule, JM4, for neuroinflammation, pending FDA-IND clearance. A single cell sorter is required for genetic molecular-based hypotheses testing to assess candidate molecular mechanisms and pursue targets. A single-cell sorter is needed to test hypotheses on a genomic level and to characterize current and developing potential therapeutic strategies in CRISPR-edited cells. A single-cell sorter would enable VANJHCS to assess current and prospective candidate targets on a genomic and mechanistic level, especially in RNAseq transcriptomics. The combined system required comprises of a single-cell analysis system that requires a Namocell Pala Single Cell Dispenser and the 10X Genomics Chromium Connect, which was recently acquired under Contract 36C24E24P0012. The Namocell Pala Single Cell Dispenser, named and included in the original grant application, will provide dissociated cells that are then input into the 10X Genomics Chromium Connect. The RNA-sequencing will identify thousands of different cells and be able to report gene expression levels for every gene in every cell. This solves a problem examining expression levels in tissue samples that complicate analyses because different cell types are present. Namocell, under ProteinSimple, is the sole manufacturer and distributor of the Namocell Pala Single Cell Dispenser.
Product Specifications
The Single Cell Dispenser shall:
Dispense single cells into 96-well plate in 1 min or 384-well plate in 6 minutes
Low sorting pressure (
Attachments
| File | Type | Posted |
|---|---|---|
| 36C24E24Q0011_1.docx | DOCX document |
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