SBSSN_75N95023Q00481.pdf

SB SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95023Q00481

2. Title: Basic fluorescence microendoscope and snap-in cannulas, patchcords and fiber light sources to use with existing Doric Basic Fluorescence Microscopy System

3. Classification Code: 6640 Laboratory equipment and supplies

4. NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing

5. Size Standard:1,000 employees

6. Description:

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations.

The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses;

HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; and

(4) availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality.

For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non- Manufacturer Rule).

Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond.

Purpose and Objectives: The Neuronal Circuits and Behavior Unit (NCBU) of the Cellular Neurobiology Research Branch (CNRB), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), uses a combination of state-of-the-art optogenetic, electrophysiology, two-photon fluorescence endomicroscopy, immunohistochemistry, and behavioral assays to elucidate the neuronal basis of survival behaviors, such as feeding, and determine how these behaviors are disrupted in eating disorders and drug addiction.

NIDA is in need to is to procure a Basic fluorescence microendoscope and snap-in cannulas, patchcords and fiber light sources to use with existing Doric Basic Fluorescence Microscopy System for the ongoing work investigating neuronal circuits that contribute to opioid use disorder and natural/motivated behaviors such as feeding and fight-or-flight, including optogenetic experiments.

Generic Product Name: Basic fluorescence microendoscope and snap-in imaging cannuala and dual LD light source.

Project requirements: A Capable Offeror must demonstrate its ability to provide the following Doric Lenses brand name or equal items to the Government:

Fluorescence microendoscope

• Fluorescence Microscope Driver – Gen 3 with integrated LISER and 470nm LED light Source (FMD3_LISER_LED470)

• LISER Bandpass Filter: 612 nm / 69 nm, 25.0 mm Dia. (LBPF_612/069)

• Fluorescence Microscope Holder (FMH_400)

• Mono Fiberoptic Patchcord (MFP_400/430/LWMJ-0.48_1m_FC-FC)

• Clamp for Fluorescence Microscope Holder (CLAMP_FMH)

• Assisted 1x1 Pigtailed Fiber-optic & Electric Rotary Joints - 24 contacts, HDMI + 4 auxiliary contact connectors, 400 um NA0.57 fibre, 1m input, optimized for fiber photometry & microscopy (AHRJ-OE_1x1_PT_400-0.57_FC_24_HDMI+4)

• Mono Fiberoptic Patchcords (MFP_400/430/LWMJ-0.48_1m_FC-CM3 and MFP_480/500/1000-0.63_1m_FC-CM3)

• Dummy Twist-on Microscope Body, type L (eDTMB-L)

• efocus Optogenetically Synchronized Fluorescence Microscope Body Gen 3 - GCaMP/NpHR (eTOSFM3_445/616)

• Electrical cable for efocus Fluorescence Microscope Body Gen 3 (UFGJ_1000)

• Twist-on Imaging Cannula, Model L-V, 0.5mm, Depth range: 2.7mm – 5.7mm (eTICL_V_500)

• Protrusion Adjustment Ring Set (PARS_L)

• USB3.0 Behavior Tracking Camera system Color (BTC_USB3.0_CO)

• High performance workstation Snap-in imaging cannuala and dual LD light source

• Dual LD Fiber Light Source/ 450nm - 75 mW / 638nm - 80 mW

(LDFLS_450/075_638/080)

• Snap-in Imaging Cannula, Model L-V (SICL_V_500_80)

• Mono Fiberoptic Patchcord (MFP_200/230/900-0.48_1m_FC-ZF1.25)

• Twist-on Imaging Cannula, Model L-V, 0.5mm (eTICL_V_500)

• Splitter Branching Patchcord Type B Central jacket

(SBP(2)_200/230/3000/900-0.48_1m_FCM-2xZF1.25)

A Capable Offerors must demonstrate its ability to provide a system with the following Doric Lenses brand name or equal Salient Requirement:

Fluorescence microendoscope

• System uses eFocus electrowetting lenses that permit Z-space adjustments of up to 300 microns.

• Adjustments can be made while the mouse is awake and performing a behavioral task.

• Equipped with a large (650 x 650 micron) field of view, which is important for maximizing the number of neurons in an analysis.

• eFocus cannula includes a “twist-on” design that ensures that the miniscope can be quickly and securely attached and detached from the mouse with minimal restraint.

• The software used for image acquisition, Doric Neuroscience Studio with upgrades.

Snap-in imaging cannuala and dual LD light source

• The optical fiber length is adjusted to fit the desired electrical cable length.

• The ultralight fiberglass jacket is lighter and more flexible.

• Additional safety for personnel by eliminating the need to collimate the light prior to collection into a patch cord.

• Laser unit is compact.

Other important considerations: This requirement may include the use of options to extend the period of performance in order to provide ongoing maintenance, warranty, and customer services support as well as options for increased quantities for component parts. Please confirm if you can provide additional/optional 1-year quote.

In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25.

Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products in full or partially should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program.

Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non- Manufacturer Rule).

Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice.

However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number.

The information submitted may be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

All responses to this notice must be submitted electronically. The response must be submitted to Polina Klimenkova, Contracting Officer, at e-mail address polina.klimenkova@nih.gov.

mailto:polina.klimenkova@nih.gov

The response must be received on or before July 15, 2023 at 3:00 PM, Eastern Time.

“Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”