Purchase Description_75N95022Q00157.pdf
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- Super-Resolution Microscope equipped with stochastic single photon imaging system Federal contract opportunity
- Solicitation number
- 75N95022Q00157
About this file
This document includes a purchase description and solicitation for a super-resolution microscope equipped with stochastic single photon imaging system. The National Institute on Aging requires this equipment to achieve the highest possible resolution for optical imaging of cell ultrastructure at the nanoscale. The solicitation seeks a fixed-price order for a Zeiss Elyra7 KMAT microscope or equal, capable of 30-60nm resolution in 2D and less than 100nm in 3D, including localization of molecular clusters using phase gradients. Responses are due by September 16th, 2022, with delivery within 6 months of award. Technical capability and past performance will be more important than price in evaluating quotes for this brand name requirement from the Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse.
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Other files for this federal contract opportunity
| File | Type | Posted |
|---|---|---|
| D-FAR 52.204-24_Nov_2021_75N95022Q00157.pdf | ||
| D-FAR 52.204-26_Oct_2020_75N95022Q00157.pdf | ||
| Invoicing Instructions With IPP_4-21-2022.pdf | ||
| D-FAR 52.212-4 Addendum_75N95022Q00157.pdf | ||
| D_FAR 52.212-5 May 2022_75N95022Q00157.pdf | ||
| Invoicing Instructions Without IPP_4-21-2022.pdf |
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Text version
Version 11-30-2016-1 FAR Part 11—Describing Agency Needs
PURCHASE DESCRIPTION
1. Statement of Need and Purpose: A super-resolution microscope equipped with stochastic single photon imaging system is required by the National Institute on Aging (NIA). Super-resolution light microscopy by stochastic photon methods achieves the highest possible resolution by optical imaging. This capability is not available at the NIA.
Several projects in NIA would make use of this capability allowing the imaging of the nano-anatomy of cell ultrastructure.
2. Background Information and Objective: The ability to localize ryanodine receptors and other molecular clusters in 3 dimensions using a phase gradient was developed by a group at University of Oslo for which Dr. Stern served on a PhD thesis committee.
They demonstrated that the pattern of clustering of ryanodine receptors, crucial for cardiac excitation-contraction coupling and arrhythmias, was different than previously known, and was labile, subject to remodeling in heart failure and under the impact of stress hormones.
3. Generic Name of Product: Super-resolution microscope equipped with stochastic single photon imaging system
4. Purchase Description: Zeiss Elyra7 KMAT super-resolution (PALM/STORM) microscope
5. Salient characteristics: Super-resolution microscope equipped with PALM/STORM stochastic single photon imaging system capable of imaging fluorescent probes at a resolution of 30-60 nm in 2 dimensions and less than 100 nm in 3 dimensions. The ability to localize ryanodine receptors and other molecular clusters in 3 dimensions using a phase gradient. One workstation to perform image analysis separate from microscope system itself.
6. Quantity: 1
7. Delivery Date: 6 Months after award
8. Period of Performance: 1 year warranty and service contract to be included
File details come from the government source that posted it. Updated .