Notice Of Intent to Sole Source.pdf

NOTICE OF INTENT to Sole Source

1. SOLICITATION NUMBER:

75N95023Q00544

2. TITLE:

RNAscope HiPlex Mouse RNA Probes

3. CLASSIFICATION CODE:

Q301 – Medical Laboratory Testing

4. NAICS CODE:

541380 –Testing Laboratories & Services.

5. RESPONSE DATE:

August 10, 2023 at 3:00 pm EST

6. PRIMARY POINT OF CONTACT:

Llakim Dubroff Llakim.Dubroff@nih.gov Phone: (301) 443-6677

7. DESCRIPTION:

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT)

SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN

COMPETITION (INCLUDING BRAND-NAME).

The National Institute on Drug Abuse (NIDA), Office of intends to award a sole source contract under the authority of Federal Acquisition Regulation (FAR) Subpart 13.106-1

(b) Soliciting from a single source. For purchases not exceeding the simplified acquisition threshold, contracting officers may solicit from one source if the contracting officer determines that the circumstances of the contract action deem only one source reasonably available. This contract will be awarded to Advanced Cell Diagnostics, Inc., 7707 Gateway Blvd Ste 200, Newark, California 94560-1268.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET

ASIDE STATUS

The intended procurement is classified under NAICS code 541380 with a Size Standard of $16,500,000 in revenue or less.

mailto:Llakim.Dubroff@nih.gov mailto:Llakim.Dubroff@nih.gov

REGULATORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures. Contracts awarded using FAR Part 13—Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6—Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization).

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2023-04 dated June 2, 2023.

DESCRIPTION OF REQUIREMENT

PURPOSE AND OBJECTIVES:

To purchase RNAscope HiPlex Mouse RNA Probes.

Purchase Description:

Quantity: 12 mRNA probes

1. RNAscope® HiPlex Probe - Mm-Sst-T8 - Mus musculus somatostatin (Sst), mRNA (Catalog 404631-T8)

2. RNAscope® HiPlex Probe - Mm-Prkcd-T3 - Mus musculus protein kinase C delta (Prkcd) mRNA (Catalog 441791-T3)

3. RNAscope® HiPlex Probe - Mm-Crh-T9 - Mus musculus corticotropin releasing hormone (Crh), mRNA (Catalog 316091-T9)

4. RNAscope® HiPlex Probe - Mm-Gfap-T7 - Mus musculus glial fibrillary acidic protein (Gfap), transcript variant 1, mRNA (catalog 313211-T7)

5. RNAscope® HiPlex Probe - Mm-ITGAM-T12 - Mus musculus integrin alpha M (Itgam), transcript variant 1, mRNA (Catalog 311491-T12)

6. RNAscope® HiPlex Probe - Mm-Rbfox3-T2 - Mus musculus RNA binding protein fox-1 homolog (C. elegans) 3 (Rbfox3) transcript variant 1 mRNA (Catalog 313311-T2)

7. RNAscope® HiPlex Probe - Mm-Nr3c1-T11 - Mus musculus nuclear receptor subfamily 3 group C member 1 (Nr3c1) mRNA (Catalog 475261-T11)

8. RNAscope® HiPlex Probe - Mm-Crcp-T4 - Mus musculus nuclear receptor subfamily 3 group C member 2 (Nr3c2) mRNA (Catalog 810161-T4)

9. RNAscope® HiPlex Probe - Mm-Oprm1-T6 - Mus musculus opioid receptor, mu 1 (Oprm1), mRNA (Catalog 315841-T6)

10. RNAscope® HiPlex Probe - Mm-Oprk1-T5 - Mus musculus opioid receptor, kappa 1 (Oprk1), transcript variant 1, mRNA (Catalog 316111-T5)

11. RNAscope® HiPlex Probe - Mm-Penk-T10 - Mus musculus preproenkephalin (Penk), mRNA (Catalog 318761-T10)

12. RNAscope® HiPlex Probe - Mm-Pdyn-T1 - Mus musculus prodynorphin (Pdyn), mRNA (Catalog 318771-T1)

• A bioinformatics service fees for probes design (Catalog 320269)

• RNAscope® HiPlexUp Reagents and Cleaving Solutions (Catalog 324399 /

324190)

• RNAscopeTM Intro Pack for HiPlex12 Reagents Kit (488, 550, 650) (Catalog

324443)

Salient characteristics RNAscope Hiplex V2 is capable of multiplexing fluorescent dection of 12 targets simultaneously. It is expected a single incubation of the 12 “ZZ” probes with high specifity. Following steps will amplify and assign fluorophores for each probe. Pictures will be taken in rounds of 3 probes and the in each round the previous fluorophors will be cleaved and inactivated to avoid inespecific overlap.

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION

(INCLUDING BRAND-NAME) DETERMINATION

The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, Advanced Cell Diagnostics, Inc. (ACD) is the sole source company and supplier that renders this specific RNAscope analysis.

The essential characteristics of the mRNA probes that limit the availability to a sole source are their exclusive design. Only this suggested source can furnish the requirements, to the exclusion of other sources, because it is a trademark of ACDbio.

The materials must be compatible in all aspects (form and function) with existing materials currently used in our lab. We currently use mRNA probes from ACD, and the new materials must be compatible with our materials to ensure data continuity.

By using ACD kits and probes, we have gathered previous data. However, with the acquisition of the Hiplex kit, we are enhancing our capacity to collect larger volumes of data while ensuring consistent continuation of our ongoing studies. Moreover, this upgrade opens up broader possibilities for future research endeavors.

Additionally, these kits will be used in several ongoing research projects and are critical to maintain the integrity and continuity of the research. Therefore, only ACD is capable of meeting the needs of this requirement.

The intended source is:

Advanced Cell Diagnostics, Inc.

7707 Gateway Blvd Ste 200 Newark, California 94560-1268

CLOSING STATEMENT

THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by the closing date and time of this announcement and must reference 75N95023Q00544. Responses must be submitted electronically to Llakim Dubroff, Contract Specialist, at Llakim.Dubroff@nih.gov U.S. Mail and Fax responses will not be accepted.

mailto:Llakim.Dubroff@nih.gov