NOTICE OF INTENT to Sole Source.pdf

NOTICE OF INTENT to Sole Source

1. SOLICITATION NUMBER: 75N95023Q00200

2. TITLE: CellInsight CX5 System for the Antiviral Program for Pandemics

3. CLASSIFICATION CODE: 6640

NAICS CODE: 334516: Analytical Laboratory Instrument Manufacturing

RESPONSE DATE:

April 11, 2023, at 12:00 PM ET

4. PRIMARY POINT OF CONTACT:

Kaitlyn Landi Kaitlyn.landi@nih.gov Phone: 301.827.1804

5. DESCRIPTION:

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT)

SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN

COMPETITION (INCLUDING BRAND-NAME).

The National Institute on Drug Abuse (NIDA), Office of Acquisition (OA) the National Center for Advancing Translational Sciences (NCATS), intends to negotiate and award a purchase order without providing for full and open competition (including brand-name) to Life Technologies Corporation 5781 Van Allen Way Carlsbad, CA 92008 for CellInsight CX5 System for the Antiviral Program for Pandemics.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET

ASIDE STATUS

The intended procurement is classified under NAICS code 334516: Analytical Laboratory Instrument Manufacturing with a Size Standard of 1000.

REGULATORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures. Contracts awarded using FAR Part 13—Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6—Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization).

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2022-08 dated October 22, 2022.

DESCRIPTION OF REQUIREMENT

PURPOSE AND OBJECTIVES:

One inherent limitation of the response to the SARS-CoV2 pandemic was a readily apparent limitation of high-throughput screening capacity for biologic organisms requiring BSL3 level containment. This required the preparation of pre-spotted assay ready plates to be sent to contract research organization for screening, following their desired plate type, format, and screening in only their established assay. As such, NCATS was limited to screening SARS-CoV2 assay in 384-well format, instead of our normal 1536-well plate format, not only limiting the assay throughput but also necessitating re-tooling of compound libraries. This growing demand has led to the need for additional screening instrumentation not just for assay ready plates but to be used as a general laboratory instrument for assay development projects.

To address this limitation, the National Center for Advancing Translational Sciences (NCATS) has newly established a Biosafety Level 3 (BSL3) Laboratory to support its ongoing SARS-CoV2 work. To facilitate screening, we request the purchase of a CellInsight CX5, which is a compact benchtop high-content screening platform, offering automated quantitative cell analysis. This high-containment biological laboratory is required due to the added safety infrastructure required for propagation and handling of SARS-CoV2, including increased air handling requirements and greater security, not currently available within the 9800-laboratory complex.

Overall, this project will support ongoing work for small molecule and combination screening, in silico virtual screening, nanobody/antibody design and optimization that are part of NCATS’s ongoing work to support the pandemic response. In addition, we are performing in vitro assays to support efforts to characterize the response of variant SARS-CoV2 viruses to current vaccine and therapeutic interventions.

Essential features:

Brightfield capabilities:

The CellInsight CX5 instrument utilizes transmitted light, allowing you to explore more cell biology without the restriction of fluorescent dyes.

Instrument Connect feature:

Connect Platform provides scientists with a secure place to store, share and analyze their data.

Automation with Cytomat incubators:

Cytomat incubators have internal database-driven inventory management and device grouping, providing you with a complete solution to the automated, high-throughput analysis.

Scalable:

The CellInsight CX5 instrument addresses the problem of scale with a continuum of robotic solutions depending on your lab’s needs.

Cat.# Description Qty. Manufacturer CX51114S CELLINSIGHT CX5+STORE+ORBITOR 1 ThermoFisher Scientific TRN00315 SMARTSTART, HCA CX5, 2 DAY, CS TRAINING 1 ThermoFisher Scientific

ESTIMATED DELIVERY:

One-Time delivery within 30 calendar days ARO

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION

(INCLUDING BRAND-NAME) DETERMINATION

The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, Life Technologies Corporation 5781 Van Allen Way Carlsbad, CA 92008 is the only vendor in the marketplace that can provide the services required by NIDA .

The intended source is:

Life Technologies Corporation 5781 Van Allen Way Carlsbad, CA 92008

CLOSING STATEMENT

THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size.

All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95023Q00202. Responses must be submitted electronically to Kaitlyn Landi, Contract Specialist, at kaitlyn.landi@nih.gov and KJ Shaikh, Contracting Officer, at kj.shaikh@nih.gov. U.S. Mail and fax responses will not be accepted.

mailto:kaitlyn.landi@nih.gov mailto:kj.shaikh@nih.gov