Purchase_Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute of Neurological Disorders and Stroke (NINDS) is establishing a new laboratory that will use cutting-edge physiological, imaging, and behavioral methods to investigate the relationship between human neurological disorders and brain function at the molecular, synaptic, cellular, and circuit levels. The new laboratory will include two multiphoton microscopes. These will require a large anti-vibration table tailored to address the low frequency (1-3 Hz) vibration present in NIH Building 35A, as well as to dampen the higher frequencies typically problematic in multiphoton microscopy.

2. Background Information and Objective:

The NINDS will soon establish the Laboratory of Circuits, Synapses, and Molecular

Signaling (LCSMS), which will be led by the new Scientific Director. The LCSMS will study fundamental issues of synaptic transmission, neuronal excitability, neuromodulation, and neural circuit activity using animal models (principally, the mouse). These issues will be related to human neurological disorders, such as Alzheimer’s and other neurodegenerative disorders, and will be explored in brain areas including (but not limited to) the amygdala, basal forebrain cholinergic areas, the ventral hippocampus, and the prefrontal cortex.

One major line of research will employ multiphoton microscopy from both brain slices and awake, head-fixed mice. The two multiphoton microscopes (in vitro and in vivo) will sit on a single large (5’ x 10’) anti-vibration table. The table will be placed in NIH Building 35A in a room made up of the present rooms 3B-415 and 3B-214. The building is subject to a non-trivial vibration in the range 1-3 Hz. It is therefore imperative that the anti-vibration table incorporate both piezoelectric active cancellation and pneumatic isolation to counter vibrations over a wide range of frequencies.

3. Generic Name of Product:

Anti-vibration table for multiphoton microscopy

4. Salient characteristics

The NINDS LCSMS requires an anti-vibration table suitable for holding the components of two multiphoton microscopes. The table must be 5’ x 10’ in XY dimension. It will sit in

Building 35A in a room presently composed of rooms 3B-415 and 3B-214.

• The equipment must have both piezoelectric active vibration cancellation technology and pneumatic vibration isolation technology.

• The equipment must have a digital controller with menu driven interface and LCD display.

• The vibration isolation effect should be fast settling, begin by 0.6 Hz, and meet these specifications: -6 dB at 1 Hz, -20 dB at 2 Hz, -25 dB or more above 3 Hz. In terms of transmissibility (defined as the ratio of transmitted acceleration to injected acceleration for a 2000 lb load), the table should have transmissibility less than 1 both vertically and horizontally for all frequencies greater than 1 Hz. Transmissibility should be less than 0.5 both vertically and horizontally for frequencies greater than 2

Hz. Transmissibility should be less than 0.1 both vertically and horizontally for frequencies greater than 10 Hz.

• The optical top should be 5’ x 10’ x 12” with individual sealed holes, non load bearing cups, and flatness + 0.005”.

• The equipment must have 3/16” thick ferromagnetic stainless-steel top plate, matted finish; ¼-20 countersunk and tapped holes @1” o.c. array, with a honeycomb core .49”2 cell size; 13.3 lb/ft3 density. Maximum damping, research grade.

• The contractor shall provide a Field Engineer for system initialization, optimization and certification, on site for at least three (3) days. The Field Engineer must be onsite to supervise the equipment move in and assembly that will be performed by a qualified rigging team provided by the Government. The equipment must be installed and loaded prior to arrival of Field Engineer.

• The Contractor shall provide installation assistance, load distribution adjustments, isolator cables connection and controller installation for all equipment.

5. Quantity: 1 system

6. Delivery Date:

The contractor shall deliver and install the equipment within 45 days after receipt of order.

Delivery must be FOB destination and include inside delivery. On-site training must take place within two (2) weeks of equipment installation. The equipment shall be delivered and installed between the hours of 8:00am and 5:00 pm, Bethesda, MD local prevailing time.

The contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup, installation, and an on-site 1-day training session for 10 staff members.

7. Warranty/Service:

Contractor shall warrant that the Equipment will be free from material defects for a period of twelve (12) months from the date of acceptance. All service performed on this equipment shall be provided by certified and factory trained technicians. Technicians shall have the ability to diagnose the systems on site via remote access. Contractor shall provide any required replacement components due to malfunctions on-site.

8. Delivery Requirements:

The Contractor shall deliver and install the required equipment in coordination with

Government officials. Delivery must be FOB Destination and must include inside installation.

The equipment shall be delivered and installed between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday.

This system will be delivered to newly renovated space in building 35A. Coordination of delivery will be performed with the Government at the time the equipment is ready to be shipped.