LT0742 2021 PASCAL Brochure.pdf

PASCAL® Synthesis™

Photocoagulator pascalvision.com | 888.850.1223 | pascalservice@iridex.com

Industry Leading PAttern SCAnning Laser Technology PASCAL® Synthesis™

PASCAL® represents a quantum leap in ophthalmic treatment technology and is committed to helping you deliver effective results for your patients. Demanding ophthalmologists choose PASCAL® because of its speed and ease of use.

Developed in partnership with Stanford University, the PASCAL® method of photocoagulation treats retinal conditions using a single spot or a user-selected pattern array. Most importantly, it was designed to provide control and flexibility in the treatment of eye conditions.

Pattern scanning method is the preferred way and I believe it’s standard of care.

Mark S. Blumenkranz, MD HJ Smead Professor and Chair Director of the Byers Eye Institute at Stanford University

Experience the PASCAL® Advantage The collaboration between researchers and clinical experts resulted in a laser system recognized and used by physicians worldwide.

Overview of PASCAL Synthesis

1. Optional

2. Mauricio Turati, Felix Gil-Carrasco, Adolfo Morales, Hugo Quiroz-Mercado, Dan Anderson, George Marcellino, Georg Schuele, DanielPalanker. “Patterned

Laser Trabeculoplasty.” Ophthalmic Surg Lasers Imaging 2010;41: 538-545.

The PASCAL technology was developed in partnership with Stanford University

Exclusive Precision Spots with Multi-Fiber Beam Technology

Reduced power and short pulses produce less discomfort during treatment

Rapid pattern scanning laser delivery

Precise alignment and continuous laser pulse directed by high speed galvanometers

Enhanced laser delivery slit lamp

Endpoint Management for sub-threshold treatment1

Pattern Scanning Laser Trabeculoplasty (PSLT)1 for IOP reduction2

PASCAL Conventional Laser

Courtesy: Dr. Daniel Palanker Associate Professor Department of Ophthalmology, School of Medicine, and Hansen

Experimental Physics Laboratory Stanford University.

Unlike conventional laser burns, PASCAL’s shorter pulse duration (10ms) results in faster procedures with less pain, collateral damage and scarring for your patients.3

3. Manish Nagpal et. al., “Comparison of laser photocoagulation for diabetic retinopathy using 532-nm standard laser versus multispot pattern scan laser. “ RETINA 30:452-458,2010

Now Featuring A New Laser Delivery Slit Lamp

SL-PA04

Ergonomic Design and Improved Optical Design Improved coaxiality between the slit illumination and the aiming beam provides better visibility of the peripheral retina.

Comfortable Observation with our NEW Binocular System The CB-8 binocular system with 8-degree angle provides clear vision. The smooth movement of the PD adjustment makes it easier to find a comfortable PD range. New magnification configuration improves visibility of the treatment area. The 5x, 8x, 13x, 20x and 32x magnification grouping allows for a wider view of the treatment area.

Power Adjustment Knob Quick and precise adjustment of the laser treatment power.

LED Illumination Sharp and homogeneous LED illumination for comfortable viewing

Gooseneck Fixation Target Easy to adjust the fixation target.

Micro-manipulator Allows precise alignment of aiming beam and treatment delivery.

Endpoint Management™ Sub-threshold Treatment for Retinal Disorders Endpoint Management (EpM)* is a pattern sub-threshold retinal laser therapy that uses a unique algorithm to control laser power and pulse duration, optimizing the therapeutic effect of the laser at sub-visible levels.

Endpoint Management is Mathematically Precise

The Arrhenius Integral coupled with extensive data on retinal laser-tissue interactions defines the algorithms for Endpoint Management. By use of this formula, heat induced changes in the retina are controlled as Endpoint Management simultaneously modulates the laser power and duration, providing linear control over a non-linear process.

Landmark™ Patterns

The Landmark feature is a useful tool for tracking the sub-visible areas which have been treated, assisting with the treatment process and taking the guesswork out of successive treatments.

Easy Operation

The yellow dots displayed on the user interface treatment pattern display indicate the laser spots that will be delivered using the energy level set by Endpoint Management. While Endpoint Management is active, the red dots indicate the laser spots that will be delivered at the titration energy level ("100% level") and will provide the "Landmark" reference points outlining the treated area.

TIME

THRESHOLDS

HEMORRHAGE

BARELY VISIBLE

NON-VISIBLE

FA

OCT

NON-THERAPEUTIC

ENDPOINT

MANAGEMENT

ALGORITHMS

P O

W E

R

EpM ON / Landmark OFF

EpM OFF EpM ON / Landmark ON

40 %

*EpM is optional software

EpM OFF EpM ON / Landmark OFF

EpM ON / Landmark ON

Endpoint Management™

Clinical Case

Diabetic Macular Edema

Diabetic Retinopathy

Dr. Daniel Lavinsky | Porto Alegre, Rio Grande do Sul, Brazil

64 years old with Type 2 DM for over 20 years. Severe nonproliferative diabetic retinopathy with macular edema OU. Patient submitted to one intravitreal injecton of Ranibizumab.

She had a panic attack during the procedure and refused additional injections.

Physician:

Patient:

Pre-EpM VA 20/60

Pre-EpM VA 20/60

1 year and 9 months Post-EpM VA 20/20

1 year Post-EpM VA 20/20

Physician:

Patient:

Dr. Daniel Lavinsky | Porto Alegre, Rio Grande do Sul, Brazil

46 years old, male with decreased visual acuity since childhood due to nystagmus.

Patient refused use of steroids or other medications.

* Courtesy: Lavinsky D, Palanker D. Non Damaging photothermal therapy for the retina: initial clinical experience with chronic central serous retinopathy.Retina. 2015;35(2):213-22.

IOP reduction of >-30% was maintained through 18months

By Miho Nozaki, MD, PHD, and Kaweh Mansouri, MD, MPH/Nov/Dec 2015 Insert to Glaucoma Today

0d 1W 1M 2M 3M 4M 5M 6M 8M 9M 10M 12M 16M 18M

PSLT PG O�

IO

P m m

H g

Follow-up Period

IOP After PSLT

*1 PSLT is optional software

*2 Mauricio Turati, Felix Gil-Carrasco, Adolfo Morales, Hugo Quiroz-Mercado, Dan Anderson, George Marcellino, Georg Schuele, Daniel Palanker.

“Patterned Laser Trabeculoplasty.” Ophthalmic Surg Lasers Imaging 2010;41: 538-545.

PSLT™ (Pattern Scanning Laser Trabeculoplasty) treatment for IOP Reduction

Pattern Scanning Laser Trabeculoplasty (PSLT)*1 is a tissue-sparing laser treatment for reducing intraocular pressure in open angle glaucoma. PSLT provides a rapid, precise, and minimally traumatic computer-guided treatment that applies a sequence of patterns onto the trabecular meshwork.*2

Clear Advantages of PSLT

• Computer guided treatment

• Sub-visible procedure

• Clinical studies show an IOP reduction of 24% in 6 months

• Ability to retreat if necessary

Ease of Operation

PSLT provides a computer guided placement of the treatment patterns ensuring full coverage of the trabecular meshwork and eliminating the chance of overlap.

RPE

ILM

RPE

ILM

PASCAL's® Versatility Maximizes Your Workflow

More Patterns. More Treatment Options.

PASCAL offers a vast selection of patterns. The extensive pattern palette provides many variations to suit nearly every clinical need.

Uninterrupted Aiming Beam

Bright and clear continuous aiming beam can help the operator to precisely aim at the target position.

Multi-Fiber Beam Delivery System

PASCAL Synthesis multi-fiber beam delivery provides one dedicated fiber optic for each spot size.

This increases depth of field compared to zoom optic laser systems.

Multi-Fiber Beam Delivery Zoom optic laser systems

Wide depth of focus

Narrow depth of focus

Profile image of beam delivery:

PASCAL has uniform energy distribution

Profile image of beam delivery:

Other lasers have "hot spots" in the beam profile

Family of Premier Retina Lasers:

Sophisticated Technology, Elegantly Designed In order to help you and your patients, we never stop improving. When you understand the science behind our advancements, you’ll understand why PASCAL is really a synthesis of innovations, all working together to further the field of ophthalmology.

PASCAL® Synthesis

• Available in 577 and 532 nm wavelengths (yellow/green)

• Integrates seamlessly with Topcon SL-PA04,

• SL-D7, Haag-Streit™, BM900 and BQ900

PASCAL® TwinStar

• Includes both 577 nm + 638 nm wavelengths (yellow+red) in a single system

• Integrates seamlessly with Topcon SL-PA04 slit lamp

PASCAL® LIO*

(Laser Indirect Ophthalmoscope)

• Allows physicians to offer laser photocoagulation treatments to patients unable to sit at a slit lamp

• Small and lightweight headset battery offers up to 2 hours of use without recharging

* Optional accessory to Synthesis, not available with TwinStar

Topcon SL-PA04 G4 and Y4

Topcon SL-D7 G7 and Y7

Topcon SL-PA04 (TwinStar)

PASCAL® LIO

Case Images

Proliferative Diabetic Retinopathy Retinal Hole

Post laser photocoagulation Post laser photocoagulation

( 2 months )

Result is greater patient comfort with decreased pain. Much safer, much more effective.

Pravin U. Dugel, MD Retinal Consultants of Arizona

L E A R N M O R E pascalvision.com

*Courtesy: Hiroyuki Nomoto, MD, Nomoto Eye Clinic

IMPORTANT In order to obtain the best results with this instrument, please be sure to review all user instructions prior to operation. Not available for sale in all countries. Please check with your local distributor for availability in your country.

Synthesis (Y7 / G7 / Y4 / G4) Synthesis TwinStar

Laser

Patterns

Power

Power Control

Treatment

Aim Beam

Aim Beam Power

Delivered Spot Size

User Interface

Slit Lamp Compatibility

Laser Console Dimensions

Input Power Requirement

Cooling

*1 : 577nm is for Single, Pattern scan, PSLT and Endpoint Management. 638nm is only for single spot.

*2: Triple arc is only for Angle treatment by PSLT *3: EpM is optional software *4: Optional accessory *5: Pulse Durations 5ms is only for Triple arc

577nm , 638nm*1Available in 577nm or 532nm Optically

Pumped Semiconductor (OPSL)

577nm: 50, 100, 200, 400μm

638nm: 60, 200μm

50, 100, 200, 400μm

Single Spot, Array, Triple Arc*2, Triple Ring, Arc, Line, Circle, Enhanced Octants (EpM*3), Wedge, Hexagon

0 - 2000mW 577nm: 0 - 2000mW

638nm: 0 - 600mW

3-D Controller*4 and Touch Screen User Interface

Pulse Durations 5 to 1000ms*5

635nm diode 670nm diode

Adjustable to < 1mW

3D Controller*4 and Touch Screen Control Panel Display (26.5 cm; 10.4 in)

Haag-Streit BM900 and BQ900,Topcon SL-PA04 and SL-D7 Topcon SL-PA04 Height: 23 cm (9 in)

Length: 31 cm (12 in)

Width: 38 cm (15 in)

Weight: 15 kg (35 lbs)

100 - 240 VAC; 50/60Hz 200VA

TEC / Air Cooled

Specifications pascalvision.com | 888.850.1223 | pascalservice@iridex.com Contact PASCAL® Service today to learn more.

LT0742.A 04.2021