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STATEMENT OF WORK

Neurodegenerative Disease Scientific Data Consulting Services

GENERAL INFORMATION

Title of Project:

Neurodegenerative Disease Scientific Data Consulting Services

Statement of Need, Purpose, and/or Objective:

The purpose of this requirement is to procure scientific data consulting services related to neurodegenerative diseases in support of National Institute on Aging (NIA) Laboratory of Neurogenetics (LNG).

Background Information:

The NIA LNG uses scientific data consulting services on an array of projects including rapid cloud-based processing of exome and genome sequences in Parkinson’s disease; facilitating cloud based environments for real-time multi-center collaborations on large *-omics datasets; predictive modeling and remote phenotyping in Parkinson’s disease; international collaborative efforts in charting neurological disease progression; and building robust analytics infrastructure for reproducible and reliable statistical genetics applications.

Period of Performance:

The required period of performance is a one-year base period and four (4) (12) one-year optional periods.

Place of Performance:

The primary place of performance shall be the contractor’s site via remote efforts. Work shall also be performed at the Government facility located at 35 Convent Drive, Room 1A-1102, Bethesda, MD 20892 as requested.

Type of Contract Contemplated:

A Firm Fixed Price Contract with Options to Extend the Term of the Contract is contemplated.

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The Contractor shall provide scientific data consulting support services in relation to neurodegenerative diseases as follows:

· Provide guidance and recommendations regarding statistical and computing processes related to analyzing the genetic bases of neurological disease.

· Manipulate genome-scale and next generation sequence data as directed.

· Analyze molecular genetics and genomic data, including genome-wide genotype data, microarray based expression datasets, targeted resequencing, whole exome sequencing, and full transcriptome sequencing; using standard biostatistics/bioinformatics packages as well as machine and deep learning methods.

· Develop, implement, and maintain cloud-based analytic pipelines for generating and analyzing multi-modal datasets.

· Collaborate with NIH scientists and other NIH collaborators to perform multi-national analytics and data management efforts related to the genomics of neurodegenerative diseases within a meta-analysis and “big data” framework.

· Prepare manuscripts related to analyses performed in relation to this requirement.

LEVEL OF EFFORT

The minimum estimated level of effort for this requirement is one (1) contractor employee on a part-time basis for 1,500 hours per year, or approximately thirty (30) hours per week. The maximum estimated level of effort for this requirement is four (4) contractor employees on a part-time basis for 3,400 hours per year.

GOVERNMENT RESPONSIBILITIES

The Government will provide data for analysis, computing resources, and office space to the contractor personnel working under this effort. All data provided to the Contractor must be treated as confidential and not be disclosed to any third party. FAR Clause 52.245-1 Government Property shall be applicable to this requirement.

OTHER CONSIDERATIONS

Travel:

The contractor may be required to travel within the contiguous United States to provide the services described in this statement of work. Travel reimbursement will be provided for such required travel.

All travel arrangements must be made in accordance with Federal Travel Regulations and must be approved by the Contracting Officer and authorized by the Contracting Officer’s Representative prior to being finalized or invoiced. Contracting Officer approved and Contracting Officer’s Representative-authorized travel shall not exceed $10,000.00 annually.

Please note that time spent travelling may not be billed to the Government. Please see the Federal Travel Regulation for allowable travel expenses, such as fares, rental fees, mileage payments, and other expenses related to transportation per FTR §301-10.2.

Key Personnel:

The Contractor employees providing services for this effort shall be considered key personnel. Key Personnel requirements are as follows:

Lead Scientific Data Consultant

· A PhD in a data science discipline

· At least 10 years of experience providing genome-related scientific data analytics and data management support services.

· At least fifty (50) publications focused on statistical analyses in the neurogenetics field.

Scientific Data Consultant

· A MS or 2-5 years in a data science discipline

· At least 5 years of experience providing genome-related scientific data analytics and data management support services

The proposed Key Personnel will become subject to the provisions of Health and Human Services Acquisition Regulation (HHSAR) Clause HHSAR 352.237-75 Key Personnel as follows:

The key personnel specified in this contract are considered to be essential to work performance. At least 30 days prior to the contractor voluntarily diverting any of the specified individuals to other programs or contracts the Contractor shall notify the Contracting Officer and shall submit a justification for the diversion or replacement and a request to replace the individual. The request must identify the proposed replacement and provide an explanation of how the replacement's skills, experience, and credentials meet or exceed the requirements of the contract. If the employee of the contractor is terminated for cause or separates from the contractor voluntarily with less than thirty (30) days’ notice, the Contractor shall provide the maximum notice practicable under the circumstances. The Contractor shall not divert, replace, or announce any such change to key personnel without the written consent of the Contracting Officer. The contract will be modified to add or delete key personnel as necessary to reflect the agreement of the parties.

Reporting Requirements:

The Contractor shall provide written monthly reports to the Contracting Officer’s Representative (COR) and the Chief of the Laboratory of Neurogenetics which summarize all efforts performed during the reporting period. Reports shall be given on the first business day of each month, following the first month of award. All reports shall also include a brief conference call or meeting with the COR and Chief of the Laboratory of Neurogenetics to discuss plans for the following month.

Information Systems Security:

The Contractor must ensure that any computer system used in the course of this contract shall include the following features:

1. Any computer used in relation to this contract must be patched with most updated IT Security Patches.

2. Any Contractor computer used in relation this contract must have virus protection loaded and running with definition files that are updated on at least a daily basis.

3. Hard drives and portable media used for this contract must be encrypted using the FIPS 140-2 standard.

4. Contractors are required to take NIH Security and Privacy Training annually http://irtsectraining.nih.gov/

5. Contractor are required to sign the NIH non-disclosure agreement http://irtsectraining.nih.gov/NIH_Non-Disclosure_Agreement.pdf

6. Contractors are required to report any lost or stolen NIH data to the NINDS ISSO within one hour of knowing of the lost or theft even if the data is on a Contractor furnished computer.

7. Contractors are required to adhere to the NIH IT rules of behavior which can be found at https://ocio.nih.gov/InfoSecurity/training/Pages/nihitrob.aspx

8. Any computers used in reference to this contract must be assessed for vulnerabilities.

9. Any computers used in reference to this contract must be backed up on an external hard drive which is password protected.

10. Any computers used in reference to this contract must have auditing enabled such that if an incident occurred then that event could be reconstructed.

11. Any computers that are used in reference to this contract must employ at a minimum user name and password authentication or if possible two factor authentications.

12. Any computer used in relation to this contract must be password protected. All Password must meet the NIH standard such that users must choose passwords that have at least eight characters and at least three of the following types of characters:

a. capital letters

b. lower case letters

c. numeric characters

d. special characters (!@#$%^&*()_+|~-=\`{}[]:";'<>?,./) Data Rights:

The National Institute on Aging shall have unlimited rights to and ownership of all deliverables provided under this procurement including reports, analyses, recommendations and all other deliverables. In addition, it includes any additional deliverables required by contract change. The definition of “unlimited rights” is contained in Federal Acquisition Regulation (FAR) 27.401, “Definitions.” FAR clause 52.227-14, “Rights in Data-General,” shall be incorporated into any resulting award by reference.

Section 508—Electronic and Information Technology Standards:

Section 508 of the Rehabilitation Act of 1973 requires that Federal agencies’ electronic and information technology (EIT) is accessible to people with disabilities. The Federal Acquisition Regulations (FAR) Final Rule for Section 508 (EIT Accessibility) can be found at www.section508.gov and at the Access Board’s Web site at https://www.access-board.gov/508.htm. Unless it is an “undue burden” or compliant products or services do not exist, the products must conform to Section 508. The contractor must state that they will comply with the requirements of Section 508 or cite a justifiable reason for an exception.

Confidentiality of Information:

Confidential Information means information or data of a personal nature about an individual, or proprietary information or data submitted by or pertaining to an institution or organization. Confidential Information or records shall not be disclosed by the Contractor without written authorization from the Contracting Officer. Whenever the Contractor is uncertain with regard to the confidentiality of or a property interest in information under this contract, the Contractor should consult with the Contracting Officer prior to any release, disclosure, dissemination, or publication.

Collaboration Requirements:

It is required that all contractors involved with the NIH community work collaboratively with federal staff and other contractors towards the NIH mission and other affected organizations and follow the direction of the Contracting Officer’s Representative (COR), and/or the designated Federal Project Manager(s)/Lead(s). This collaboration includes day-to-day activities, support, development, knowledge transfer and creating and sharing documentation when required.

Non-Personal Service Statement

Contract employee performing services will be controlled, directed and supervised at all times by management personnel of the contractor. Actions of contractor employees may not be interpreted or implemented in any manner that results in any contractor employee creating or modifying Federal policy, obligating the appropriated funds of the U.S. Government, overseeing the work of Federal employees, providing direct personal services to any Federal employee or otherwise violating the prohibitions set forth in Parts 7.5 and 37.1 of the Federal Acquisition Regulations (FAR).

Statement of Work, April 2018