BLSA_purchase_product_systems_equipment_description smr.doc

TEMPLATE PURCHASE DESCRIPTION

INSTRUCTIONS: This template should be used when purchase equipment, products, supplies, software, software license agreements, warranty agreements, and maintenance service agreements. Remove the instructions from the purchase description before submitting with the purchase request.

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: National Institute on Aging (NIA) requires state-of-art assay kit for quantification of serum/plasma on one 96-well plate of a Simoa 4-plex assay for human Abeta40, Abeta 42, GFAP, NF-light. These biomarkers will be assayed using biospecimens from participants followed for many years through the Baltimore Longitudinal Study of Aging.

2. Background Information and Objective: The current project will investigate the biology of cognitive resilience and cogntive impairment, including for Alzheimer disease (AD) in participants in the Baltimore Longitudinal Study of Aging (BLSA). The current project makes use of stored biospecimens from BLSA participants assessment to investigate potential biomarkers and mechanistic factors, including Abeta40, Abeta 42, GFAP, and NF-light. This project requires the use of high throughput equipment and sensitive assays for the identification biomarkers in serum/plasma of Abeta40, Abeta 42, GFAP, NF-light. These biomarkers will provide important insights into the biological underpinnings of cognitive resilience and cognitive impairment years before any symptoms would be apparent. New insights may lead to novel treatments to help prevent or delay AD.

3. Generic Name of Product: Simoa 4-plex 96-well plate assays

4. Purchase Description: Manufacturer’s Name: Quanterix

Model, Type, Catalog and/or part numbers: Please refer to the attached Quotation for more details.

5. Salient characteristics:

Contractor shall provide the NIA/LBN the 96 well plate assays and all necessary reagents to include:

· Complete kit for running one 96-well plate of a Simoa 4-plex assay for human AB40, AB42, GFAP and NF-light, using technology that combines high selectivity and efficiency of transfer for selected ions symmetrically across the isolation window.

· Complete kit for 96-well plate of a Simoa assay for Abeta40, Abeta 42, GFAP, NF-light.

· Complete assay kit for running one 96 well plate (or 96 tubes) of target analyte. Includes calibrator concentrate, calibrator diluent, beads detector, SBG, RGP, and sample diluent. Novel ETD HD-high dynamic range ETD provides significantly increased fragment ion coverage.

6. Quantity: 56 kits

7. Delivery Date: Within 90 days after after contractor receipt of award

8. Period of Performance: NA

9. Option(s): NA Version 11-30-2016-1

FAR Part 11—Describing Agency Needs