B Sources Sought.pdf

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SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95022Q00236

2. Title: Waters Acquity UPLC I-Class Plus Triple with QDa System Purchase

3. Classification Code: 6640 -- LABORATORY EQUIPMENT AND SUPPLIES

4. NAICS Code: 334516

5. Description: ANALYTICAL LABORATORY INSTRUMENT MANUFACTURING

This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background: The Antiviral Program for Pandemics (APP) is an initiative that seeks to accelerate antiviral development through early discovery and pre-clinical development of safe and effective oral antivirals. The initial priority for the APP is to develop treatments for SARS-CoV-2 and other coronaviruses, with the program expanding to address other virus families with pandemic potential. NCATS will apply its proficiency in drug discovery and development and its cutting-edge technologies to fill critical needs of the APP, such as (i) target validation, (ii) high-throughput screening (HTS) for drug starting points, (iii) medicinal chemistry for lead optimization, and (iv) preclinical, investigational new drug (IND)-enabling development. APP chemists within DPI are tasked with the discovery and development potential small molecule antiviral treatments for a range of viruses that have pandemic potential. In order to meet the increased demand for sample purification and analysis, the Antiviral Program for Pandemics (APP) needs to rely on instrumentation that can handle throughput of experimentation, as well as help accelerate the discovery chemistry rate in the laboratory.

As part of this initiative, the Antiviral Program for Pandemics (APP) is working with the Analytical Chemistry Core (ACC) on the development of an automated purification platform that would operate as a stand-alone system or an integrated module within the automated synthetic laboratory. This automated purification system named FluidCore is a dual arm fraction collection bed that incorporates analytical and purification LC systems into a single automated platform. The custom system will be integrated into the SMART centralized sample purification and processing platform as an upgrade to the current workflow. The ACC is currently working on the design and development of this innovative and custom purification system by retrofitting our current Waters Autopurification semi-preparative purification instrument. The Waters ACQUITY UPLC I- Class PLUS Triple with QDa system, which will be the analytical LC system for FluidCore, is required as it can be readily integrated with the existing Waters purification system. Additionally, we intend to use the Waters Automation Portal as a means of transferring analytical samples from the fraction collection bed to the analytical UPLC system for analysis. The Waters Automation Portal is only compatible with the Waters

ACQUITY UPLC.

Purpose and Objectives: The purpose of this procurement is the acquisition of a Waters ACQUITY UPLC I-Class PLUS Triple with QDa system for the Antiviral Program for Pandemics (APP) within the Division of Pre-clinical Innovation (DPI) at NCATS.

Project requirements:

The requested equipment consists of the following:

• Mfr Part No. 176015111 o Part Description: ACQUITY I-Class PLUS Sys. (CM-A) w/SM-FTN-I

• Mfr Part No. 176015091 o Part Description: ACQUITY UPLC I-Class eK PDA Detector

• Mfr Part No. 700011803 o Part Description: ACQUITY I-Class PDA Tubing Single Detector

• Mfr Part No. 176003208 o Part Description: ACQUITY QDa Detector (Performance)

• Mfr Part No. 176004266 o Part Description: ACQUITY I-Class PLUS QDa Kit

• Mfr Part No. 205001275 o Part Description: Kit, Ethernet Switch Box w/ Bracket

• Mfr Part No. 186008515 o Part Description: Acquity QDa Fluidics Valve, Stainless Steel

• Mfr Part No. 700009641 o Part Description: ESI PROBE ASSEMBLY 250mm

• Mfr Part No. 176003244 o Part Description: ISM & ACQUITY Splitter Kit

• Mfr Part No. 176015027 o Part Description: ACQUITY UPLC ELSD w/Nebulizer

• Mfr Part No. 700002848 o Part Description: ACQUITY UPLC / UV and ELSD Qualification Standards Kit

• Mfr Part No. 700002741 o Part Description: ACQUITY / Quattro micro or Quattro Premier MS Start-up Solution Kit

• Mfr Part No. 176001060 o Part Description: ML 4.1 & Standard PC

• Mfr Part No. 668000273 o Part Description: MONITOR, 23"

• Mfr Part No. 741000472 o Part Description: QDa SYSTEM INSTALLATION CERT

• Mfr Part No. 176003950 o Part Description: Analytical LC-MS Solvent Install Kit

• Mfr Part No. 176015048 o Part Description: ACQUITY UPLC CM-Aux Add-on (3/4)

Anticipated period of performance: One-time delivery. Number of days after receipt of order is TBD.

Requested Response:

The intent of this sources sought notice is to define the procurement strategy (e.g. set-aside, sole source, unrestricted) for a solicitation that is intended to be posted soon.

Interested contractors are requested to respond by (1) identifying how their proposed product meets or exceeds the project requirements listed above; and (2) providing product literature, white papers, or capability statements that demonstrate their bona fide ability to supply such an item within the time frame described above.

In addition, please state your business size status and whether you are the manufacturer or authorized distributor of the item you propose.

Please note that NCATS is particularly interested in small business sources. If you are a small business, please state the type of small business (small business; HUBZone;

service-disabled, veteran-owned; 8(a); veteran-owned; woman-owned; or small disadvantaged businesses) and your size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

The information submitted must be must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contracting Officer.

Facsimile responses are NOT accepted.

The response must be submitted to Kevin Alvarez, Contracting Officer, at e-mail address kevin.alvarez@nih.gov.

The response must be received on or before May 25, 2022, 9:00am, Eastern Time.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published at SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).

mailto:kevin.alvarez@nih.gov