Attachment 1 Preclinical PET CT Purchase Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute of Mental Health, Molecular Imaging Branch requests to purchase a PET/CT scanner for its non-human primate PET (Positron Emission Tomography) imaging program.

2. Background Information and Objective:

Animal models play an important role in the translational research for drug development.

The mission of Molecular Imaging Branch is to develop various imaging probes for the brain to study psychiatric disorders in humans. The efficacy of all novel radiotracers will have to be tested in vivo in animals before being applied to humans.

The Molecular Imaging Branch acquired two microPET Focus preclinical scanner in 2006. Both scanners have reached their end of life. In order to continue its research mission, NIH proposes to acquire a new preclinical PET/CT scanner.

Because of the high resolution required to adequately image monkey and rodent brains, it is necessary that NIH obtain a dedicated small animal scanner for the animal imaging program.

3. Generic Name of Product:

Preclinical PET/CT scanner including installation and training

4. Purchase Description:

• Preclinical PET/CT scanner big enough to accommodate Rhesus

Macaque with 1 mm resolution

5. Salient characteristics

PET Scanner

1. Transaxial field-of-view (FOV) of ~ 20 cm or larger (gantry opening large enough to accommodate rhesus macaque) and an axial FOV >= 15 cm.

2. Use fast detector materials such as the LSO or LYSO scintillator with coincidence time window 5 nsec or less.

3. Support static as well as multiple bed acquisition in 3D for whole body imaging.

4. Run simultaneous reconstruction while acquiring data.

5. Include Fourier rebinning (FORE) + filtered back projection (FBP) for fast image reconstruction; correction for physical factors such as detector geometry, depth of interaction (DOI), attenuation, model-based scatter, random and deadtime.

6. Offer 3D iterative reconstruction (e.g., OSEM) with point spread function (PSF) compensation to push for higher image resolution.

7. Required to achieve:

1) a transverse resolution (FWHM) of ~ 1 mm at the center of FOV and < 2.5 mm at 4 cm from the axial center;

2) an axial resolution (FWHM) of ~ 1 mm at the center of FOV; and 3) a slice thickness of 2 mm or less.

8. Achieve an absolute sensitivity of ~ 5%.

9. Support list mode acquisition, offline histogramming and reconstruction.

10. Gantry should have a tilting feature to allow scanning monkeys in a sitting position to remain awake while performing cognitive tasks.

CT Scanner

11. Scanning field of 20 cm transaxially and 15 cm axially, similar to that of PET.

12. Able to perform various types of acquisition such as step and shot, circular and helical.

13. Reconstructed CT image should have a resolution of < 200 μm.

Workflow Management

14. High performance visualization and computational tools.

15. Fault tolerant ultra-large capacity (12 TB) integrated archiving system.

16. Parallel work: while reconstruction is running on the Reconstruction Workstation computer, the additional Post-processing Workstation must be able to analyze and quantify images from another study.

17. Support, both CT and PET, DICOM image viewer and export.

Training

18. No less than 40 hours of on-site training as well as one-week follow-up on-site training that is necessary for the routine operation of the Preclinical PET/CT scanner.

Warranty

19. Following delivery, installation, and training, one year standard warranty on all parts and labor.

20. Software upgrades for the dynamic list mode acquisition and retrospective histogramming during the warranty period.

6. Quantity: One PET/CT scanner with a one-year warranty and any software upgrade within the warranty period.

7. Delivery Date: No later 120 days after the award of the contract. The contractor shall coordinate with the Government point of contact noted in the purchase order prior to shipment.

8. Period of Performance: Following delivery, installation, and training, the new scanner shall be covered by a warranty of at least one year. The scanner is expected to be on a service contract thereafter.

9. Option(s): N/A