FINAL_Combined_Synopsis-Amendment.doc

Exhibit 11

SEQ CHAPTER \h \r 1

COMBINED SYNOPSIS / SOLICITATION

WORKFORM

(1) Action Code: Combined Synopsis/Solicitation

(2) Date: May 15, 2018

(3) Year: 2018

(4) Contracting Office Zip Code: 20892

(5) Classification Code:

(6) Contracting Office Address: 6701 Rockledge Drive

(7) Subject/Title: NextSeq 550 and MiSeq DNA Sequencers

(8) Proposed Solicitation Number: 75N92018Q0160

(9) Closing Response Date: May 21, 2018

(10) Contact Point(s):

(11) Contract Award and Solicitation Number:

(12) Contract Award Dollar Amount: TBD

(13) Contract Line Item Number(s):

(14) Contractor Award Date: Upon Award

(15) Contractor Name: TBD

(16) Description:

(17) Place of Performance: Bethesda, MD

(18) Set-Aside Status: None

(19) NAICs Code: 334516

THIS COMBINED SYNOPSIS LINE ITEM HAS BEEN AMENDED TO INCLUDE A MISEQ SYSTEM.

(i) “This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.”

(ii) The solicitation number is 75N92018Q0160 and the solicitation is being posted as a request for proposal (RFP) to procure (BRAND NAME: ILLUMINA): NextSeq 550 Sequencing System and MiSeq System on behalf of National Institutes of Health, National Institute of Human Genome Research Institute (NHGRI). NO REFURBISHED OR USED EQUIPMENT WILL BE ACCEPTED.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-97, January 24, 2018.

(iv) This is not a set-aside, the associated NAICS Codes: 334516, Analytical Laboratory Instrument Manufacturing and small business size standard is 1000 in number of employees. The acquisition is being conducted in accordance with the procedures of FAR Part 12 and FAR Part 13. All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. Offers are due by 7:30 A.M. Eastern Time (EST) on May 21, 2018. Responses must be submitted via the FedConnect webportal (www.fedconnect.net). Potential Offerors do not need to register to view a notice; however, in order to submit questions and/or response to this Notice, an account will need to be established.

(v)

Background:

The National Institutes of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI) mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals.

NHGRI Microarray Core (MAC) was established on 2000. The facility represents a consortium between the National Human Genome Research Institute (NHGRI), the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) and NHGRI NIH Intramural Sequencing Center (NISC) is a centralized research facility for performing high-throughput, large-scale DNA sequencing and sequence analysis. NISC operates several sequencing platforms in-order to meet the varied needs of the NIH community.

Purpose and Objectives:

NISC procurement of the NextSeq 550 will provide researchers rapid sequencing speed, simpler operation, availability of multiple flow cell types for maximum flexibility, and most importantly, compatibility with existing DNA Sequencer occupying the NIH Intramural Sequencing Center: three (3) MiSeq Sequencers, three (3) HiSeq 2500 Sequencers, one (1) HiSeq 4000 Sequencer, one (1) NovaSeq 6000 Sequencer, one (1) Pacific Biosciences (PacBio) RS II Sequencer, and one (1) Oxford Nanopore GridION Sequencer. The MAC microarray core lab requires the NextSeq 550 sequencer to transition from array-based transcriptomics to sequence-based transcriptomics. The NextSeq 550 sequencer fits perfectly in the core’s mission in providing a multitude of DNA and RNA applications that are not accessible through the microarray platform as well as added capability and the option to run single cell analysis that is not feasible with microarrays.

Procurement:

1. Illumina NextSeq 500 Sequencing System, Catalog Number: Quantity: Three.

2. MiSeq System, Catalog Number: SY-410-1003, Units: One

3. Freight/Handling Fee.

Anticipated Period of Performance:

Four weeks upon receipt of Contract Award Deliverables:

1. Two NextSeq 550 Sequencing Systems, 50 South Drive, Bldg. 50, Room

5232, Bethesda, MD 20892;

2. Miseq System, 10 Center Drive, Bldg. 10, Room 10C101B, Bethesda, MD 20892; and

3. One NextSeq 550 Sequencing System, 5625 Fishers Lane, Room 5S-16, Rockville, MD 20852 (With Trade-In (Hi-Seq 2500 Sequencer, Serial

Number: Doo327, Trade-In Doc Number: 2018-185, Custodial Number:

12015).

Contractor Requirements:

1. The Contractor shall deliver and install the sequencer in a space prepared by NISC within one month of receipt of the contract.

2. The Contractor shall provide on-site instruction of up to three (3) participants by a Field Applications Specialist (FAS). A training kit will be provided. Training includes Assay, Software and Bioinformatics.

3. The Contractor shall provide a 12-month comprehensive warranty.

4. The Contractor shall provide a UPS to support the sequencer and the associated computer.

Government Responsibilities:

1. The Government will keep the Equipment at all times in the environmental conditions recommended by the manufacturer. And, protect the Instrument and associated Hardware from all adverse elements, such as dirt, dust and liquids of any kind.

2. The Government will insure that instrument and ancillary parts will fit on the freight elevator, through all necessary corridors and doorways, and that the space is properly prepared for installation.

3. The Government will operate the instrument according to the training and guidelines provided by the Contractor.

EVALUATION OF PROPOSALS:

The Government will evaluate proposals that are determined technically acceptable in accordance with the Technical Evaluation factors. The Government intends to award a single contract from this solicitation. The Government reserves the right not to award a contract.

Evaluation of Proposals: The Government reserves the right to make an award without discussions based solely upon initial proposals.

Price (This will be Firm-Fixed Price): An evaluation of the offeror’s price proposal will be made to determine if proposed prices are realistic for the work to be performed, reflect a clear understanding of the requirements, and are consistent with the technical proposal. Reasonableness determinations will be made by determining if competition exists, by comparing proposed prices with established commercial or GSA price schedules (if applicable), and/or by comparing proposed prices with the Independent Government Cost Estimate (IGCE).

EVALUATION FACTORS:

The evaluation will be based on the lowest price technically acceptable (LPTA).

vi. The FAR Provision 52.212-1, Instructions to Offerors -- Commercial, applies to this acquisition and is hereby incorporated by reference. All Federal Acquisition Regulations (FAR) clauses may be viewed at http://acquisition.gov/comp/far/index.html.

The proposal must reference the RFP Number: NIHHL201800007. All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency.

All proposals shall contain the following:

1. Name of Contracting Organization;

2. Solicitation number;

3. Contract Type;

4. Total Contract Value and Discounts;

5. Description of Requirement;

6. North American Industry Classification System (NAICS) Code; and

7. DUNS, TIN or EIN Number.

ix.

In accordance to FAR clause 52.212-2, Evaluation – Commercial Items x.

In accordance with FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items, offerors must complete annual representations and certifications on- line at https://www.sam.gov/portal/public/SAM/.

xi.

FAR clause 52.212-4, Contract Terms and Conditions - Commercial Items applies to this acquisition.

xii.

FAR clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items applies to this Acquisition. Additional FAR Clauses include:

FAR clause 52.204-10, Reporting Executive Compensation and First-Tier Subcontract

Awards (JUL2013) (Pub.L. 109-282) (31 U.S.C. 6101 note).

FAR clause 52.223-18, Encouraging Contractor Policies to Ban Text Messaging while

Driving (AUG2011).

FAR clause 52.225-13, Restrictions on Certain Foreign Purchases (JUN 2008) (E.O.’s, proclamations, and statutes administered by the Office of Foreign Assets Control of the

Department of the Treasury).

FAR clause 52.232-33, Payment by Electronic Funds Transfer—System for Award

Management (JUL2013) (31 U.S.C. 3332).

xiii.

All responses must be received by May 23, 2018, 7:30 a.m. Eastern time. Responses must be submitted via the FedConnect webportal (www.fedconnect.net). Potential Offerors do not need to register to view a notice; however, in order to submit questions and/or response to this Notice, an account will need to be established. Should you require a waiver not to use FedConnect, please contact the Contracting Office: National, Heart, Lung and Blood Institute, Section 3, Branch B, Office of Acquisitions, Office of Management, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell, Contracting Officer (maxwelld@nih.gov). Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. “All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency and include the following:

1. Name of Contracting Organization;

2. Solicitation number;

3. Contract Type;

4. Total Contract Value and Discounts;

5. Description of Requirement;

6. North American Industry Classification System (NAICS) Code; and

7. DUNS, TIN or EIN Number.

xv.

All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. Offers are due by 7:30 A.M. Eastern Time (EST) on May 23, 2018. Dorothy Maxwell, Contracting Officer can be reached at (301) 827-7729 regarding any questions regarding Solicitation Number: 75N92018Q0160.

Quotations shall not be deemed received by the Government until the quotation is entered into the e-mail address inbox set forth above. Faxed proposals will NOT be accepted.

Offerors must complete annual representations and certifications on-line at https://www.sam.gov/portal/public/SAM/.