LIFE_TECH_SOW.doc

NIH Clinical Center

Critical Care Medicine Department CCMD research section Statement of Work

BACKGROUND INFORMATION

The Critical Care Medicine Department (CCMD) was established in November 1977 to provide medical care for critically ill patients throughout the Clinical Center who have potentially reversible medical problems. Critical care medicine may be defined as the observation, diagnosis, treatment, and rehabilitation of patients with overt or potential failure of vital functions.

The Department is currently composed of the following sections:

· Clinical Medical Services

· Critical Care Therapy and Respiratory Care

· Research Section

· AIDS Section

· Administrative Services

CCMD Mission

To provide high quality and cost effective clinical service that meets the needs of CC patients and NIH Institutes, to facilitate the research goals of NIH Institutes and investigators, and to conduct high quality research and training in Critical Care Medicine.

CCMD Research Section The Critical Care Medicine Department conducts active research programs in bedside clinical investigation, research in animal models, and molecular biology.

Full-time research activities commence at the beginning of the second year of the fellowship for fellows interested in the critical care subspecialty alone. For those interested in dual board eligibility, their second-year program is individually designed and consists of clinical rotations required for board eligibility in the particular subspecialties. After completion of second subspecialty training, full-time research activities commence. Major topics of research interest within the Department include:

· The immunopathogenesis of septic shock

· Studies of immune cellular function in respiratory distress syndrome, asthma, and other forms of severe pulmonary disease

· Biomarkers and novel therapies in pulmonary arterial hypertension

· Biomarkers of acute cellular rejection in heart transplantation

· Diagnosis and treatment of opportunistic infections

· Studies of immune cellular function and therapy of AIDS

· Pathogenesis and treatment of anthrax

· Emerging infectious diseases

· Biology and clinical effects of nitric oxide

· acute lung injury

· pulmonary arterial hypertension

· role as transcription regulatory factor

· Functional genomics of critical illness

· human acute inflammation

· animal model of septic shock and multiple organ failure

· pulmonary arterial hypertension

· solid organ transplantation

· Emerging Infectious Disease

· Pneumocystis

PURPOSE

The purpose of this correspondence is to request a PO to purchase the media to perform translational research evaluating the pathogenesis and treatment of high-consequence respiratory viral pathogens. Respiratory infections are the leading cause of death in children worldwide and result in significant morbidity and mortality in adults.

The CCMD is establishing a model of lung injury and sepsis to assess the efficacy of treatments and the mechanisms of the injury.

PERIOD OF PERFORMANCE

July, 2016 through July, 2017.

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