Sponsoring Agency HHS
    POP 8/11/13 - 9/29/16 (3 years)


The primary objective of this Master IDIQ is to evaluate the impact of tobacco product constituents on pharmacology and behavior using nonclinical models. To fulfill these objectives, the Government seeks a contractor to perform a series of nonclinical studies with a wide range of tasks. These tasks shall include: providing input on scientific protocols and methodologies, providing animal subjects protection including Animal Care and Use Committee (ACUC) documentation and approval, providing documentation for FDA ACUC, administering the test constituent(s), collecting behavioral, pharmacological and toxicological data, performing data analyses, and creating scientific reports. Studies will assess the impacts of tobacco product constituents on pharmacological, toxicological and behavioral outputs, including histopathology and gross pathology, clinical chemistry and hematology, safety pharmacology endpoints for cardiovascular and respiratory systems, midbrain neurotransmitter release, reinforcement/reward, dependence, withdrawal, choice behavior, and physiological effects (e.g., peak plasma levels).

  • $1.7m Aggregate Dollars Obligated
  • $1.7m Aggregate Base & Exercised Options
  • $1.7m Aggregate Base & All Options (Ceiling)

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