This $1,899,160 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS Biomedical Research and Research Training, CFDA 93.859) will support the acquisition of a state-of-the-art pulsed Q-band electron paramagnetic resonance (EPR) spectrometer at the Integrated Molecular Structure Education and Research Center (IMSERC) user facility at Northwestern University. The specialized EPR spectrometer will enable structural biology research on folded proteins, intrinsically disordered proteins, and biomolecular assemblies with applications in developing novel therapeutic agents. Key features of the system include high-power microwave excitation, arbitrary waveform generation, and cryogen-free temperature control for enabling advanced EPR techniques like double electron-electron resonance. This shared instrumentation will serve researchers across Northwestern University and the greater Chicago area, significantly expanding access to this critical EPR capability. The award period runs from September 1, 2024 to August 31, 2025.
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