This Project Grant award from the Department of Health and Human Services' National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $598,969 to Vanderbilt University Medical Center (VUMC) to acquire a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) system. The instrument, a SCIEX 7500 triple quadrupole MS with QTRAP functionality, will enable VUMC's Eicosanoid Core to significantly enhance its capabilities in detecting and quantifying low-level oxidized lipid mediators in biological samples. This advanced mass spectrometry system will support research across multiple VUMC departments studying the roles of these signaling molecules in various disease states, including cancer, diabetes, and cardiovascular disease. The award, with a period of performance from May 1, 2024 to April 30, 2025, will provide the Eicosanoid Core with state-of-the-art mass spectrometry instrumentation and associated sample preparation equipment to advance the understanding of lipid-derived signaling pathways and their clinical implications.
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