This $2,000,000 Project Grant awarded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will provide funding for The Washington University in St. Louis to acquire a new 15.2-Tesla small-animal MRI scanner. This will replace the university's existing outdated 11.74-Tesla scanner, which has become unsustainable due to high liquid helium consumption costs. The new 15.2-Tesla scanner will offer significantly improved signal-to-noise ratio, spatial...
This $2,000,000 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA #93.351) will enable Yale University to acquire a state-of-the-art 11.7T Bruker preclinical magnetic resonance imaging (MRI) system with cryogenic coil technology. The new ultra-high field MRI scanner will replace an obsolete 20-year old system, providing significantly enhanced sensitivity and resolution to support advanced functional,...
This $1,999,999 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will establish a Midwest Regional Cryo-Electron Microscopy (Cryo-EM) Facility at the University of Kansas Medical Center (KUMC). The award will fund the acquisition of a Glacios 200 kV Cryo-TEM equipped with a Falcon 4i detector and Selectris energy filter to provide high-resolution structural analysis capabilities for researchers...
The Mayo Clinic in Rochester, Minnesota received a $2,000,000 Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) to acquire a state-of-the-art 7T preclinical magnetic resonance imaging (MRI) scanner. This advanced MRI system, the Bruker BioSpec 70/20, will significantly enhance the institution's research capabilities across multiple disciplines including neuroscience, cancer, cardiovascular disease, and more. The flexible...
This $3,800,000 Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA #93.351 will support Washington University in St. Louis' acquisition of a Siemens whole-body human 7-tesla magnetic resonance imaging (MRI) system. The high-field 7-T MRI scanner will provide enhanced signal-to-noise ratio and spatial resolution compared to lower-field 3-T systems, enabling more detailed brain imaging for 29 NIH-funded research projects at...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 provides $2,000,000 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to replace the 14T high-field vertical-bore NMR spectrometer and microimager. This specialized biomedical research equipment has been a central facility supporting numerous NIH-funded projects and training at MGH over the past four decades. The...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $392,500 to Mainehealth, a non-profit healthcare system in Portland, Maine, to purchase a state-of-the-art Bruker SkyScan1276 CMOS micro-computed tomography (microCT) system. The new microCT system will replace Mainehealth's aging imaging equipment and enable the organization's Small Animal Imaging Facility to continue providing high-resolution imaging...
The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $8,000,000 Project Grant on September 8, 2023 from the National Institutes of Health (NIH) Construction Support program (CFDA 93.352) to renovate and construct a new multi-modality pre-clinical imaging facility as part of a broader campus-wide vivarium and cancer center expansion project. The facility will serve the research needs of the entire University of Kansas Medical Center campus, providing advanced...
This Project Grant award from the National Institutes of Health's Office of Research Infrastructure Programs (CFDA 93.351 Research Infrastructure Programs) provides $378,171 to Michigan State University (MSU) to acquire a 0.7 mm ultrafast magic-angle spinning (MAS) probe for an 800 MHz NMR spectrometer. The new probe will enable high-resolution characterization of fully protonated and native cellular samples, significantly reduce experimental time, and support research on carbohydrate-based...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $2,000,000 to upgrade the University of Iowa's current CT scanner to a Siemens NAEOTOM Alpha photon-counting CT scanner. The new scanner will eliminate beam hardening artifacts and reduce electronic noise, while improving spatial resolution and enabling multi-material separation for enhanced ventilation and perfusion imaging....
ZERO CRYOGEN BOILOFF TECHNOLOGY MAGNET: A REGIONAL ANIMAL MRI RESOURCE - ABSTRACT THIS PROPOSAL REQUESTS SUPPORT FOR A NEW ANIMAL MRI SCANNER MAGNET AND GRADIENTS TO REPLACE THE ORIGINAL EQUIPMENT THAT WAS DESTROYED IN A RECENT UNTIMELY AND UNEXPECTED MAGNET QUENCH. AFTER REPLACING THE MAGNET AND GRADIENTS, THE ANIMAL MRI CORE WILL AGAIN HAVE A STATE-OF-THE-ART SYSTEM THAT SUPPORTS RESEARCH FROM NIH-FUNDED INVESTIGATORS REPRESENTING FOUR IDEA STATE INSTITUTIONS IN THE MIDWEST: UNIVERSITY OF KANSAS MEDICAL CENTER, UNIVERSITY OF KANSAS-LAWRENCE, KANSAS STATE UNIVERSITY, AND PITTSBURG STATE UNIVERSITY. THE UPGRADED SYSTEM WILL ALSO SUPPORT THE RESEARCH INITIATIVES OF SEVEN NIH-FUNDED CENTERS: UNIVERSITY OF KANSAS ALZHEIMER'S DISEASE CENTER, UNIVERSITY OF KANSAS CANCER CENTER, KANSAS INTELLECTUAL & DEVELOPMENTAL DISABILITIES RESEARCH CENTER, UNIVERSITY OF KANSAS POLYCYSTIC KIDNEY DISEASE RESEARCH & TRANSLATION CORE CENTER, FRONTIERS: UNIVERSITY OF KANSAS CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE, AND TWO COBRE CENTERS (KANSAS STATE UNIVERSITY COGNITIVE AND NEUROBIOLOGICAL APPROACHES TO PLASTICITY CENTER AND KANSAS CENTER FOR METABOLISM AND OBESITY RESEARCH. OUR USER GROUP INCLUDES >20 NIH-FUNDED INVESTIGATORS WHO HAVE ADOPTED MRI METHODOLOGY TO ANSWER COMPLEX BIOMEDICAL QUESTIONS IN NEUROLOGICAL, RENAL, PULMONARY, AND HEPATIC DISEASE AND THROUGH STUDIES IN NEURODEGENERATION, METABOLISM, OBESITY, PAIN, AND DEVELOPMENTAL BIOLOGY. WITH THIS SCANNER, THESE INVESTIGATORS WILL HAVE ACCESS TO HIGH-PERFORMANCE ELECTRONICS THAT WILL PROVIDE MANY NEW ACQUISITION SEQUENCES FOR DATA ACQUISITION AND AN INTUITIVE GRAPHICAL USER INTERFACE BASED ON CLINICAL MRI SCANNER DESIGNS WHICH IS MORE USER-FRIENDLY TO OPERATORS, THUS OPENING ACCESS TO A WIDER USER GROUP INCLUDING GRADUATE STUDENTS AND POST-DOCTORAL FELLOWS SINCE THEIR TRAINING PERIOD WILL BE DRAMATICALLY SHORTER. ACCORDINGLY, WE ANTICIPATE REDUCED IMAGING COSTS TO INVESTIGATORS FUNDS. THIS SYSTEM WILL BE INSTALLED IN THE UNIVERSITY OF KANSAS MEDICAL CENTER HOGLUND BIOMEDICAL IMAGING CENTER. IT WILL BE SUPPORTED BY STRONG INSTITUTIONAL COMMITMENTS TO OPERATING COSTS AND AN OUTSTANDING TEAM OF IMAGING SCIENTISTS WHO WILL COLLABORATE WITH OUR MAJOR AND MINOR USERS ON STUDY DESIGN, IMAGING PROTOCOL DEVELOPMENT, ANALYSIS OF DATA AND INTERPRETATION OF RESULTS. WE EXPECT THIS SYSTEM TO QUICKLY AND DRAMATICALLY INCREASE IN RESEARCH ACTIVITY AT THE UNIVERSITY OF KANSAS MEDICAL CENTER AS WELL AS IN THE NEARBY REGION.