The National Institutes of Health (NIH) awarded a $1,431,300 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the Regents of the University of Michigan to acquire and operate a state-of-the-art combined optical tweezers-single molecule super-resolution fluorescence microscope. This specialized instrument will be housed in the university's open-access Single Molecule Analysis in Real-Time (SMART) Center to support a broad range of biomedical research programs across the state of Michigan, including those at Michigan State University, Oakland University, and the Van Andel Institute. The instrument will advance a significant number of NIH-funded studies, enabling novel investigations into protein and RNA folding, phase separation in disease, and other biophysical and cell biology research. The grant will fund the acquisition of the LUMICKS C-Trap DYMO system, which provides quadruple laser tweezers, confocal fluorescence microscopy, and super-resolution imaging capabilities, thereby accommodating a wide variety of single-molecule experiments. The project aims to enhance research rigor, productivity, and training of the next generation of single-molecule scientists.
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