Project Grant RF1MH133777
- This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is focused on developing novel tools to enable researchers to better understand how brain structure relates to brain function. The $323,978 award to the Child Mind Institute Inc. will fund three main efforts: Extending the institute's "BrainBuilder" tool to reconstruct 3D mesoscale microstructural atlases of the human and macaque cortex, including...
- This $1,988,947 Project Grant award from the National Institute of Mental Health (NIMH), under the Federal Grant Program "Mental Health Research Grants" (CFDA 93.242), will fund the development of a scalable high-throughput proteomics profiling pipeline to generate comprehensive molecular atlases of distinct brain cell types in the mouse brain. The key products and services to be delivered include: Increasing the multiplexing capability to 100-plex for antibody-based proteomic...
- This $21.4 million cooperative agreement from the National Institute of Mental Health will fund research to identify gene regulatory elements that can target and manipulate specific neuronal cell types and brain circuits across species, including in human organoids. Awarded on September 1, 2022 to the Broad Institute, Inc. with completion by August 31, 2025, the funding supports the Mental Health Research Grants program. The Broad Institute and collaborators at Harvard University will profile...
- This $371,288 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to map the evolutionary expansion of the human cerebral cortex and analyze associated transcriptional changes compared to the macaque cortex. The project aims to generate highly accurate maps of cortical expansion and leverage advances in single-cell transcriptomics to study the divergence of cortical cell types between humans...
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- The National Institute of Mental Health (NIMH) awarded a $3,138,556 Cooperative Agreement to Duke University under the Mental Health Research Grants program (CFDA 93.242) to develop RNA-based technologies for scalable and programmable cell type access across diverse vertebrate species. The project, titled "RNA Programmable and Scalable Brain Cell Type Tools Across Vertebrates," aims to establish a platform for systematically screening and validating RNA sensors to monitor and...
- The National Institute of Mental Health (NIMH) awarded a $769,352 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Leland Stanford Junior University (Stanford University) to develop an engineered bioprinting platform to study neural migration in brain assembloids. This research aims to enhance the quality, reproducibility, and complexity of neural assembloids, which are three-dimensional cellular models representing different brain regions, to strengthen their...
- This $2,623,223 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund the development of CLOUDSLEAP, a cloud-based platform to enhance accessibility to deep learning-based motion capture technology for behavior quantification. The key products and services to be delivered through this 3-year grant include: Enabling annotation, visualization, and sharing of pose tracking datasets directly from the browser,...
- The National Institute of Mental Health (NIMH) awarded a $2,515,724 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Regents of the University of Michigan to further develop NTracer2, a cloud-based platform for brain image visualization and neuron tracing. The project aims to establish NTracer2's SISF data framework as a scalable image data standard, continue developing the NTracer2 content delivery network and application server, and deploy the full-stack...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement. Key products will include open-source analytics tools and cloud-native pipelines for cross-modal data analysis, as well as a user-friendly data portal for visualization and navigation of multi-modal single cell data. This 3-year project seeks to facilitate advancements in understanding the cellular architecture of the brain through an accessible, collaborative research ecosystem.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.4m | 8/21/23 |