Project Grant R61CA302625
- This federal Project Grant award of $204,474, awarded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), is supporting research to define the transition from deep cell quiescence to senescence. The University of Colorado, the awardee, will use time-lapse microscopy and molecular assays to investigate the mechanisms controlling quiescence depth and the relationship between deep quiescence and senescence. The research aims to determine if senescence is a form of...
- This federal Project Grant award of $680,598 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research to understand the role of the Cullin-5 complex in regulating T cell dysfunction in cancer. The research aims to develop new therapeutic approaches to engineer T cells with durable effector function, by targeting the Cullin-5 complex to prevent T cell dysfunction caused by chronic tumor antigen stimulation. The award was provided to the...
- The National Cancer Institute awarded a $150,784 Project Grant under the Cancer Biology Research federal grant program (CFDA 93.396) to the University of North Carolina at Charlotte (UNC Charlotte). The award period runs from September 1, 2025 to August 31, 2027. The project aims to investigate the role of post-translational modifications on the HSP70 chaperone protein and its impact on regulating the cell cycle protein cyclin D1, which is often dysregulated in cancer. Specifically, the research...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- The National Cancer Institute (NCI) has awarded a $636,185 Project Grant under the Cancer Biology Research federal grant program (CFDA 93.396) to the University of Toledo's Health Science Campus division. The grant funding, which runs from February 1, 2025 to April 10, 2025, supports research into the mechanisms of prostate cancer metastasis and recurrence. The project aims to investigate how "dormancy mimicking" can impede the progression of prostate cancer metastases, an area that is...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $1,625,853 Project Grant to New York University (NYU) on December 13, 2024. The grant will support NYU's research to map and characterize the role of 3D "hubs" - regulatory DNA elements that interact with multiple loci - in the context of T-cell leukemia (T-ALL), early T-cell progenitor leukemia (ETP-ALL), and T-cell lymphoma. The project aims to better define how these 3D chromatin structures are rewired...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- The Project Grant award of $424,734 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development of a novel spatial proteomics approach to profile immune cell types and their locations within a tumor microenvironment. The University of Illinois, the awardee, aims to integrate 3D microscopy techniques with bottom-up proteomic assays to offer deep proteome profiles of specific immune cells at various subregions of a mouse tumor (Aims 1 and 2). The goal is...
- This $292,028 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the mechanisms by which oncogene amplification leads to genome instability and the development of therapy-resistant cancer clones. The research will be conducted by the Sloan-Kettering Institute for Cancer Research in New York and is scheduled to run from August 1, 2025 to July 31, 2030. Using single-cell genomic sequencing techniques, the project aims...
This federal Project Grant award of $627,676 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research at the University of North Carolina at Chapel Hill (UNC-CH) to develop and test novel biosensors for measuring the depth of cell cycle quiescence in cancer cells. The goal is to better understand how different states of quiescence, from shallow to deep, relate to tumor progression and treatment resistance. The 3-year project will define the accuracy and dynamic range of these newly generated biosensors in cancer cell lines and then deploy them in xenograft experiments to analyze quiescence depth heterogeneity within tumors. This research aims to provide fundamental insights into the biology of cancer cell dormancy, which is a key driver of relapse, and could lead to improved therapeutic strategies targeting quiescent cancer cell populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.7k | 8/11/25 |