The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,168 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Institut Pasteur DU Cambodge, a foreign-owned non-profit research organization located in Phnom Penh, Cambodia. The grant, awarded on December 27, 2024, with a final completion date of November 30, 2027, aims to establish robust and long-term stable in vitro cultures of Plasmodium vivax (P. vivax) malaria clinical isolates. The project leverages the organization's access to multiple P. vivax strains from endemic regions in Cambodia to facilitate the selection of strains adapted for in vitro culture. The research will also investigate optimal culture conditions, explore the use of hematopoietic stem cells and mesenchymal stromal cells to support P. vivax survival, and establish a 3D organoid model. Additionally, the project will utilize the most promising P. vivax strains to develop genetically modified parasites using CRISPR-Cas9 technology, with the goal of studying drug resistance mechanisms and identifying potential resistance markers.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $267.2k | 12/27/24 |