This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $545,612 to The Ohio State University to conduct research aimed at reducing adipose tissue dysfunction and metabolic complications after spinal cord injury (SCI). The key objectives are to evaluate the extent to which modulating the A2D1 subunit of voltage-gated calcium channels can normalize adipose tissue function, dissect the cellular mechanisms underlying A2D1-dependent changes in adipose tissue lipolysis, and explore the role of vascular cells in adipose tissue dysfunction and inflammation after SCI. The award, effective from September 11, 2024 through August 31, 2025, is expected to provide novel insights into the molecular causes and mechanisms underlying maladaptive sensory processing and adipose tissue function following SCI, potentially facilitating the development of strategies to reduce metabolic and cardiovascular complications in this patient population.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $545.6k | 9/10/24 |