Project Grant R56HL168657
- This $722,299 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research initiative to use deep learning techniques to study normal variation in aortic valve hemodynamics and its link to the development of aortic stenosis. The primary objectives are to: 1) Measure aortic valve parameters in 100,000 UK Biobank participants using deep learning models, validate the measurements at UCSF, and develop models to identify...
- This Project Grant award of $116,250 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support research at The Johns Hopkins University to study the prevalence, risk factors, and progression of calcific aortic valve disease (CAVD) and severe aortic stenosis in persons over 75 years old. The research aims to: 1) identify long-term risk factors for the development of aortic valve calcification, 2) create population percentiles for aortic valve...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $742,323 to Vanderbilt University to develop a new bioprosthetic aortic valve made from the pulmonary visceral pleura (PVP) tissue. The research aims to demonstrate the PVP valve's superior mechanical durability, calcification resistance, and hemodynamic performance compared to current bioprosthetic valves, in order to improve the long-term durability of...
- This $298,368 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a novel device for treating mitral valve regurgitation. The project aims to optimize the device design and procedure through bench testing, followed by acute in vivo studies to demonstrate the feasibility of the approach. The funding recipient, Link Medical LLC, has invented a catheter-based technology intended to restore proper mitral...
- This $148,568 federal Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of inflammation and sex-specific differences in the progression of aortic valve stenosis (AVS). The key objectives are to: 1) delineate how secreted factors from valve cells impact macrophage phenotype and vice versa in a sex-dependent manner, and 2) elucidate sex-specific differences in AVS...
- This federal Project Grant award of $725,060.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award supports research to investigate the role of bone morphogenetic protein 9 (BMP9) and 10 (BMP10) in the development of arteriovenous malformations (AVMs) in hereditary hemorrhagic telangiectasia (HHT), an inherited disorder. The research aims to elucidate the mechanistic basis for the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This federal Project Grant award of $1,356,922.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of novel hydrogel-coated electrospun (HES) biomaterials for replacement heart valves. The key objectives are to: Identify optimal biomaterial and leaflet geometry characteristics to develop replacement heart valves with greater durability, resistance to thrombosis, and improved hemodynamics. This will leverage the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the mechanistic relationship between bicuspid aortic valve (BAV) structure, mechanical stress, and the development of premature calcific aortic stenosis. The $147,486 grant, awarded on September 5, 2025, will enable the Medical College of Wisconsin to conduct this research using mouse models of human disease integrated with in vitro...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
This $750,345 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Pittsburgh. The funding supports research to investigate the role of telomerase reverse transcriptase (TERT) in the osteogenic reprogramming of aortic valve interstitial cells, which can lead to calcific aortic valve disease. The project aims to elucidate the epigenetic and transcriptional changes directed by TERT during this osteogenic reprogramming process, visualize the dynamics of TERT and STAT5 interaction, and define the contribution of specific inflammatory cell types in valve calcification using 3D in vitro cell co-cultures and spatial RNA sequencing. This research may enable the development of non-invasive therapies to halt, prevent, or even reverse aortic valve calcification, a major unmet medical need. The award period runs from August 1, 2024 to July 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $750.3k | 8/1/24 |