The University of Missouri System received a $776,719 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), to develop intelligent fibrous biomaterials integrated with multimodal biosensing and feedback-based interventions for treating infected chronic wounds. The key objectives are to fabricate hierarchical fibrous biomaterials that can promote wound healing, combat infections, and monitor wound status, as well as to evaluate the efficacy of these intelligent biomaterials in treating diabetic mouse wounds and ex vivo human skin wounds. The University of Nebraska Medical Center received a sub-award to fabricate and characterize the hierarchical biomaterials and test their antimicrobial and wound healing efficacy. The project aims to create translational telemedicine solutions that can improve chronic wound care, reduce healthcare costs, and minimize patient exposure risks associated with frequent hospital visits.