Project Grant R44AI186932

Award Date 8/8/24
Completion Date 7/31/25
Dollars Obligated $300K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98104, USA
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The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $292,746 Cooperative Agreement to Tsrl, Inc. (doing business as Therapeutic Systems Research Laboratories), a woman-owned small business located in Ann Arbor, Michigan. The purpose of this award is to conduct a Phase 1 clinical trial to assess the pharmacokinetics, safety, and tolerance of a zanamivir transdermal system in healthy subjects. This...
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The National Institute of Allergy and Infectious Diseases (NIAID) awarded Orlance, Inc., a woman-owned small business, a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an enhanced seasonal influenza DNA vaccine. The project aims to combine the advantages of a closely matched seasonal influenza vaccine with a universal influenza vaccine to provide more robust and durable protection, especially for the elderly and immunocompromised populations most vulnerable to influenza. The key products and services to be delivered include:

  1. Comparing a novel doggybone DNA vaccine formulation against Orlance's current plasmid DNA formulation to select a lead vaccine candidate.
  2. Evaluating the lead enhanced seasonal DNA vaccine formulation against a traditional inactivated seasonal influenza vaccine for immunogenicity and efficacy in aged mice and non-human primates.

If successful, these preclinical studies are intended to advance the lead enhanced seasonal influenza DNA vaccine candidate to human clinical trials. The award has a performance period from August 8, 2024 to July 31, 2025.

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