Project Grant R44AI179440
- This $649,896 federal Project Grant awarded by the U.S. Department of Agriculture's (USDA) National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program supports the development and testing of an mRNA vaccine cocktail against influenza A viruses (IAV) in livestock. The project aims to create a universal influenza vaccine that can provide broad protection against diverse IAV strains, including highly pathogenic avian influenza (HPAI) H5N1...
- The Defense Health Agency awarded Flugen Inc. a $6,237,445 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to optimize downstream recovery and stabilization of the drug substance for their intranasal influenza vaccine. The three-year grant also supports research on concurrent administration of Flugen's H3N2 M2SR monovalent influenza vaccine with inactivated flu vaccines in older adult populations. This award builds on Flugen's previous federal grants...
- The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...
- This Project Grant award, totaling $390,942.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The goal of the project is to use self-assembled protein nanocages (SAPNs) as a universal flu vaccine platform to enhance the effectiveness of influenza vaccines. Specifically, the SAPNs will present multiple copies of three highly conserved influenza antigens: trimeric...
- This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $305,000.00 in funding to Immuno Nano Med, Inc. to demonstrate the feasibility of producing a novel room-temperature-stable, dry-powder inhalable influenza vaccine. The goal is to develop an innovative, next-generation influenza vaccine technology that can promote public health by eliminating the pain points of current flu vaccines, such as the need...
- Flugen Inc. was awarded a $5.6 million Project Grant from the Defense Health Agency under the Military Medical Research and Development federal grant program (CFDA 12.420) for the period of April 1, 2023 through March 31, 2026. The grant will support Flugen's work to develop scalable manufacturing and toxicity testing methods for an intranasal M2SR influenza vaccine. The Military Medical Research and Development program aims to transform military and public health through innovative medical...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,968 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Viva Viral Vaccines, Inc. to develop a broad-spectrum, multivalent vaccine platform for pandemic and seasonal influenza. The platform leverages innovations in the production of influenza neuraminidase (NA) proteins in mammalian cells, enabling the development of VLP-based vaccines that can provide broad heterologous...
- This $314,363 Project Grant was awarded on September 11, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research grant program (CFDA 93.855) to Via Therapeutics, LLC, a for-profit company based in Austin, Texas. The grant supports the development of a microneedle-based mRNA flu vaccine for transcutaneous immunization. The goal is to create a stable, patient-friendly influenza vaccine delivered through the skin rather than by...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute to develop a broad-spectrum influenza vaccine. The project aims to evaluate recently discovered neuraminidase broadly neutralizing antibodies (NA BNAbs) and engineer NA immunogens that can engage diverse BNAb precursors, a strategy called germline targeting. This protein engineering effort...
- This federal Project Grant award of $454,278.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop an adjuvanted intranasal influenza vaccine capable of generating lung-resident memory T cells to provide broadly cross-reactive and heterosubtypic immunity. The research project, conducted by the University of Kentucky Research Foundation, aims to characterize the T...
CLINIC-READY MACH-1 GENE GUN FOR DELIVERY OF A UNIVERSAL INFLUENZA DNA VACCINE - PROJECT SUMMARY ORLANCE HAS DEVELOPED A LEAD UNIVERSAL INFLUENZA (UFLU) DNA VACCINE TO ADDRESS THE NEED FOR A VACCINE THAT CAN PROTECT FROM ANNUAL INFLUENZA AND THE EMERGENCE OF NEW VARIANTS THAT COULD CAUSE FUTURE PANDEMICS. OUR UFLU VACCINE IS A MULTI-DOSE VACCINE DESIGNED TO INDUCE SYSTEMIC AND MUCOSAL IMMUNE RESPONSES THAT CAN PREVENT TRANSMISSION AND MINIMIZE DISEASE FROM CURRENTLY CIRCULATING AND EMERGING STRAINS BY INDUCING BROAD ANTIBODY AND CELLULAR IMMUNE RESPONSES THAT TARGET CONSERVED VIRAL SEQUENCES COMMON ACROSS ALL INFLUENZA SUBTYPES. UNDER PREVIOUS SBIR FUNDING, WE SHOWED THAT OUR GENE GUN (GG)-DELIVERED UFLU DNA VACCINE INDUCED BROADLY SPECIFIC (UNIVERSAL) ANTIBODY AND T CELL RESPONSES AND PROTECTION FROM DIVERSE INFLUENZA CHALLENGES IN RODENTS AND NONHUMAN PRIMATES. THIS VACCINE IS NEARING PHASE 1 HUMAN TRIALS AND WILL REQUIRE A CLINIC READY GG DEVICE TO ADMINISTER IT. HERE, WE PROPOSE TO CONTINUE DEVELOPING OUR PROMISING MACH-1TM GG TO DELIVER THE LEAD UFLU DNA VACCINE AND OTHER LEAD VACCINES TO HUMANS. THE MACH-1 IS A NEEDLE-FREE DEVICE THAT DELIVERS DNA- AND/OR RNA-COATED GOLD MICROPARTICLES DIRECTLY INTO EPIDERMAL CELLS USING HIGH PRESSURE GAS. IT IS PAIN FREE, REQUIRES SUBSTANTIALLY LOWER DOSES OF DNA OR RNA TO INDUCE PROTECTIVE IMMUNITY COMPARED TO OTHER DELIVERY METHODS, AND HAS BEEN ENGINEERED WITH SEVERAL INNOVATIONS TO MAXIMIZE EFFICIENCY AND REPRODUCIBILITY OF DELIVERY. HERE, WE WILL: IMPROVE THE MACH-1 BY MAKING IT PORTABLE AND EASIER TO USE (AIM 1); DEVELOP A GMP- SCALABLE DNA VACCINE FORMULATION INTO FILL AND FINISH DISPOSABLE DOSING UNITS (AIM 2), AND EVALUATE SAFETY, IMMUNOGENICITY, AND EFFICACY OF THE UFLU VACCINE DELIVERED BY THE IMPROVED MACH-1 IN MICE AND SWINE MODELS (AIM 3). SUCCESSFUL COMPLETION OF THESE AIMS WILL RESULT IN INVESTIGATIONAL NEW DRUG (IND)-ENABLING DOCUMENTATION FOR THE DELIVERY SYSTEM DEVICE AND FORMULATION PLATFORM NECESSARY TO ADVANCE OUR MACH-1 DELIVERED UFLU DNA VACCINE TO PHASE 1 TRIALS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $977.3k | 8/19/25 | ||
| Not listed | $0 | 11/22/24 | ||
| Not listed | $990.3k | 8/13/24 | ||
| Not listed | $990.3k | 8/13/24 | ||
| Not listed | $0 | 6/24/24 |