Project Grant R44AG092210
- This $644,864 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports preclinical studies by Ridgeline Therapeutics LLC, a Houston-based biotech company, to evaluate the efficacy of their lead compound RT-002 in preventing and reversing disuse-induced muscle atrophy in aging rat models. Specifically, the project aims to determine if RT-002 treatment can mitigate the loss of muscle mass and strength during muscle disuse, as well as improve the rate...
- The National Institute on Aging (NIA) awarded a $354,000 Project Grant (CFDA 93.866 - Aging Research) to Panorama Research Incorporated, a for-profit biotech company in Sunnyvale, California. The grant will support the development of a novel therapy for sarcopenia, an age-related loss of skeletal muscle mass and strength. The research aims to generate longer-lasting versions of the adipokine Isthmin 1 (ISM1), which has been shown to promote muscle protein synthesis and suppress degradation...
- This Project Grant award from the Defense Health Agency, under the Military Medical Research and Development program (CFDA 12.420), provides $498,988 to Ridgeline Therapeutics LLC, a Houston-based biotechnology company, for research to develop transformative drugs to prevent osteoarthritis and speed recovery following traumatic joint injuries in military and civilian populations. The project aims to advance the company's small molecule therapeutics, RT-001 and RT-002, which target nicotinamide...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- This $292,279 Project Grant awarded on September 20, 2025 by the National Institute on Aging (part of the NIH's Aging Research program, CFDA 93.866) supports research conducted by Artiam Bio Inc., a minority-owned small disadvantaged biotechnology company, to validate the use of their APT101 compound for treating systemic sclerosis-associated interstitial lung disease (SSc-ILD) in an aging murine model. The grant will fund studies to evaluate the comparative efficacy of APT101 in this clinically...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This Project Grant award of $350,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Aavogen Inc. The funding will support the preclinical validation of AVGN7, a gene therapeutic for enhancing skeletal muscle mass and function, as a potential treatment for obesity and type 2 diabetes mellitus. The key objectives are to demonstrate AVGN7's ability to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $245,434 to Wake Forest University Health Sciences (WFUHS) to investigate the impacts of weight loss interventions on muscle and bone health in older adults with obesity. The 3-year project aims to develop an automated platform to analyze CT scans and measure changes in muscle quantity, quality, and bone strength. This supports an ongoing 12-month clinical trial at WFUHS that is exploring the...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This federal Project Grant award of $789,684 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research to investigate the changes in body composition, including muscle mass, that occur with anti-obesity medications known as nutrient stimulated hormone receptor agonists (NUSH-RA) therapies. The research will directly assess muscle mass using a validated deuterated creatine dilution...
This $1,339,717 Project Grant awarded on September 22, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research) supports preclinical validation of a novel small molecule drug candidate from Ridgeline Therapeutics LLC to prevent muscle loss and enhance weight loss in older adults. The research aims to advance the development of RT-002, an NNMT inhibitor compound, as a potential therapeutic intervention to address obesity, muscle degeneration, and related age-related conditions. Key objectives include evaluating RT-002's efficacy in diet-induced obesity mouse models and assessing its impact on improving muscle strength and recovery. This grant funding enables Ridgeline Therapeutics to progress RT-002 towards an Investigational New Drug (IND) submission as a treatment to promote recovery from musculoskeletal injuries and mitigate muscle wasting in aging populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/19/25 |