Project Grant R43HL149552

This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...

The Boston University (BU) Flow Cytometry Core Facility received a $656,148 Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) to acquire a state-of-the-art BD FACSDiscover S8 spectral cell sorter with advanced imaging capabilities. This new instrument will replace BU's aging BD FACSAria II cell sorter, which can no longer reliably support the high-demand cell sorting requirements of over 90 research laboratories and multiple...

This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $399,625.00 to Cellchorus Inc., a Houston-based company specializing in advanced cell analysis technologies, to develop a high-throughput platform for profiling the functional signatures of CAR T cells from patients with relapsed/refractory large B cell lymphoma (r/r LBCL). The goal is to create a scalable, AI-powered imaging technology called Time-lapse Imaging Microscopy in...

The National Cancer Institute has awarded a $275,627 Project Grant to Link Biosystems Inc., a self-certified small disadvantaged business and for-profit organization, to develop the ONXPANSION bioreactor workflow. This workflow aims to enable efficient expansion of patient-derived induced pluripotent stem cells into clinically relevant cell doses to support autologous cell therapy applications. The grant supports efforts to de-risk the utility of Link Biosystems' bioreactor technology for...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...

The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $1,128,062 Project Grant under CFDA 93.351 to The Feinstein Institutes For Medical Research, the research arm of Northwell Health, to acquire a BD FACSymphony S6 SE spectral cell sorting platform. This high-parameter fluorescent-activated cell sorter analyzer will enhance the organization's clinical and translational research capabilities, allowing researchers to isolate specific, rare cell...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $693,423 to Baylor College of Medicine to develop and validate a novel microfluidic device capable of purifying platelets for pediatric and neonatal transfusions. The goal is to create a simple, disposable device that can effectively remove contaminants from platelet suspensions while preserving high-functioning platelets. The project will optimize the efficiency of...

This $312,371 Project Grant award from the National Heart Lung and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to Biochip Labs Inc., a small business based in Cleveland, Ohio, aims to support the manufacturing and analytical validation of the Microfluidic Impedance Red Cell Assay (MIRCA) for commercial viability. The MIRCA is an in vitro diagnostic technology that measures cellular obstruction in microcapillary networks due to abnormal red blood cell (RBC) deformability...

This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $679,925 to Versiti Wisconsin, Inc. to purchase a Becton Dickinson Symphony S6 SE cell sorter. The new 5-laser, 49-detector cell sorter will upgrade the research capabilities of the Versiti Blood Research Institute (VBRI) and enable advanced multi-parameter cell sorting to support the work of 9 major and 8 minor NIH-funded researchers at the Milwaukee Regional...

The National Cancer Institute (NCI) has awarded a $554,653 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the Institute for Systems Biology (ISB) in Seattle, WA. The 4-year grant titled "RARECYTEFINDER: A BENCH-TO-BITS TOOLKIT FOR LABEL-FREE, WHOLE-SPECTRUM ANALYSIS OF RARE DISSEMINATED TUMOR CELLS IN LIQUID AND TISSUE BIOPSIES" aims to develop an innovative, unbiased method for identifying and analyzing rare disseminated tumor cells (DTCs)...